[특허]Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation

Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-035/78
출원번호	US-0084575 (2002-02-27)
발명자 / 주소	Nair, Muraleedharan G. Wang, Haibo Dewitt, David L. Krempin, David W. Mody, Dipak K. Qian, Yong Groh, David G. Davies, Audra J. Murray, Mary A. Dykhouse, Robin Lemay, Marc
출원인 / 주소	Access Business Group International LLC, Michigan State University
대리인 / 주소	Lynn Schwenning Alticor Inc.
인용정보	피인용 횟수 : 23 인용 특허 : 0

초록

The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.

대표청구항 ▼

1. A method of alleviating or reducing pain in a mammal that comprises administering an effective amount of an anthocyanin extract extracted from an elderberry plant to a mammal that is experiencing pain, wherein the extract comprises a mixture of anthocyanins that include cyanidin-3-glucoside, cyanidin-3,5-diglucoside, cyanidin-3-sambubioside, and cyanidin-3-sambubioside-5-glucoside, whereby the mixture of the anthocyanins comprises at least about 90% of the total extract, and wherein the extract is substantially free of anthocyanidins and the extract provides greater cyclooxygenase 2 (COX-2) inhibitory activity than cyclooxygenase 1 (COX-1) inhibitory activity. 2. The method of claim 1 wherein the pain is due to a condition selected from the group consisting of arthritis, dysmenorrhea, headache, joint pain, muscular pain, osteoarthritis, and combinations thereof. 3. The method of claim 1 wherein the mammal is further administered an anthocyanin extract extracted from a tart cherry plant and a bilberry plant. 4. The method of claim 1 wherein the mammal is farther administered an anthocyanin extract extracted from a tart cherry plant. 5. The method of claim 1 wherein the mammal is further administered an anthocyanin extract extracted from a bilberry plant. 6. The method of claim 4 wherein the tart cherry plant is a variety selected from Balaton, Montanorency and mixtures thereof. 7. The method of claim 1 wherein the pain is an acute pain. 8. The method of claim 1 wherein the pain is a chronic pain. 9. The method of claim 1 wherein the extract does not produce significant erosions in the gastric lining. 10. The method of claim 1 wherein the extract does not exhibit a significant propensity to induce gastric or intestinal ulceration. 11. The method of claim 1 wherein the extract is provided in a unit dosage form and wherein each dosage provides at about 20 to 50 mg of anthocyanins. 12. The method of claim 1 wherein the extract is provided in a unit dosage form and wherein each dosage provides at least about 25 mg of anthocyanins. 13. The method of claim 1 wherein the anthocyanin extract is provided in a unit dosage form and each dosage provides about 70 mg of anthocyanins. 14. The method of claim 1 wherein the mammal is a human, the dosage form is an oral dosage form, and the extract is provided by oral ingestion. 15. The method of claim 14 wherein after oral ingestion, the extract does not produce significant erosions in gastric lining.

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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 원문보기

초록

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Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 원문보기

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