Method for the purification of blood by means of hemodialysis and/or hemofiltration and apparatus for performing said method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-061/32
B01D-061/28
출원번호
US-0900450
(2001-07-09)
우선권정보
EP-0114654 (2000-07-07)
발명자
/ 주소
Pedrini, Luciano
Wiesen, Gerhard
출원인 / 주소
Fresenius Medical Care Deutschland GmbH
대리인 / 주소
Jacobson Holman PLLC
인용정보
피인용 횟수 :
76인용 특허 :
1
초록▼
The present invention refers to a method for blood purification by means of hemodialysis and/or hemofiltration, wherein to the blood in the extra-corporeal circuit of the hemodialysis and/or hemofiltration device a substitution solution is added upstream as well as downstream of the hemodialyser and
The present invention refers to a method for blood purification by means of hemodialysis and/or hemofiltration, wherein to the blood in the extra-corporeal circuit of the hemodialysis and/or hemofiltration device a substitution solution is added upstream as well as downstream of the hemodialyser and/or hemofilter. A purification effect remaining constant with a high purification performance is achieved in that one or several of the operational and/or blood parameters are controlled and that the control is carried out using at least one of the infusion rates of the substitution solutions supplied upstream or downstream of the hemodialyser and/or hemofilter. The present invention also refers to a hemodialysis and/or hemofiltration apparatus for the performance of the inventive method.
대표청구항▼
1. A method for blood purification by means of hemodialysis and/or hemofiltration using a hemodialysis and/or hemofiltration device having an extra-corporeal blood circuit in communication with a hemodialyser and/or hemofilter that is divided by a membrane, said blood circuit having an upstream supp
1. A method for blood purification by means of hemodialysis and/or hemofiltration using a hemodialysis and/or hemofiltration device having an extra-corporeal blood circuit in communication with a hemodialyser and/or hemofilter that is divided by a membrane, said blood circuit having an upstream supply line and a downstream supply line upstream and downstream, respectively, of said hemodialyser and/or hemofilter for supplying a substitution fluid, said hemodialysis and/or hemofiltration device further including a control unit connected to a measurement device, the method comprising the steps of:receiving in said extra-corporeal blood circuit blood to be purified;measuring by said measurement device at least one operational and/or blood parameter within the received blood, said operational and/or blood parameter being selected from the group consisting of trans-membrane pressure, hematocrit value and blood density;controlling, by said control unit, at least one of an infusion rate (Q s pre) of said upstream supply line and an infusion rate (Q s post) of said downstream supply line, in response to said step of measuring in order to control said at least one operational and/or blood parameter. 2. The method according to claim 1, wherein said step of controlling includes increasing the infusion rate (Q s pre) of said substitution fluid through said upstream supply line relative to the infusion rate (Q s post) through said downstream supply line when, in response to said step of measuring, it is determined that at least one of said trans-membrane pressure, said hematocrit value and said blood density is increasing. 3. The method according to claim 1, wherein said steps of measuring and controlling are performed continuously during said blood purification. 4. The method according to claim 1, further comprising the step of selecting said infusion rates (Q s pre, Q s post) such that a substantially stationary limiting membrane is formed on a side of the membrane of the hemodialyser and/or hemofilter facing a chamber through which the blood flows. 5. The method according to claim 4, wherein upon termination of said blood purification, the limiting membrane is dissolved by changing a relation of said infusion rates (Q s pre, Q s post) of said substitution fluid in the blood. 6. A hemodialysis and/or hemofiltration apparatus comprising:an extra-corporeal blood circuit for receiving blood to be purified;a hemodialyser and/or hemofilter communicating with said blood circuit;said blood circuit having an upstream supply line and a downstream supply line upstream and downstream, respectively, of said hemodialyser and/or hemofilter for supplying a substitution fluid, said upstream supply line having an upstream infusion rate (Q s pre) and said downstream supply line having a downstream infusion rate (Q s post);a measuring device including at least one sensor for recording at least one operational and/or blood parameter selected from the group consisting of trans-membrane pressure, hematocrit value and blood density; anda control unit connected to said measuring device for controlling said at least one operational and/or blood parameter by controlling at least one of said upstream and downstream infusion rates in response to data received from said measuring device. 7. The apparatus according to claim 6, further comprising a dialysis-fluid circuit in communication with said hemodialyser and/or hemofilter, wherein said at least one sensor includes pressure sensors arranged in said extra-corporeal blood circuit and the dialysis-fluid circuit, upstream and downstream of said hemodialyser and/or hemofilter, respectively. 8. The apparatus according to claim 6, wherein said at least one sensor includes sensors arranged in said extra-corporeal blood circuit upstream and downstream of said hemodialyser and/or hemofilter for detecting the hematocrit value of the blood. 9. The apparatus according to claim 6, wherein said at least one sensor inc ludes sensors arranged in said extra-corporeal blood circuit upstream and downstream of said hemodialyser and/or hemofilter for detecting blood density. 10. The apparatus according to claim 6, further comprising pumps in said upstream and downstream supply lines, respectively, said pumps controlled by said control unit to control said infusion rate (Q s pre) and said infusion rate (Q s post). 11. The apparatus according to claim 6, further comprising valves in said upstream and downstream supply lines, respectively, said valves controlled by said control unit to control said infusion rate (Q s pre) and said infusion rate (Q s post). 12. A method for blood purification by means of hemodialysis and/or hemofiltration using a hemodialysis and/or hemofiltration device having an extra-corporeal blood circuit in communication with a hemodialyser and/or hemofilter that is divided by a membrane, said blood circuit having an upstream supply line and a downstream supply line upstream and downstream, respectively, of said hemodialyser and/or hemofilter for supplying a substitution fluid, said hemodialysis and/or hemofiltration device further including a control unit connected to a measurement device, the method comprising the steps of:receiving in said extra-corporeal blood circuit blood to be purified;measuring by said measurement device at least one operational and/or blood parameter of the received blood;controlling, by said control unit, at least one of an infusion rate (Q s pre) of said upstream supply line and an infusion rate (Q s post) of said downstream supply line, in response to said step of measuring in order to control said at least one operational and/or blood parameter; andselecting said infusion rates (Q s pre, Q s post) such that a substantially stationary limiting membrane is formed on a side of the membrane of the hemodialyser and/or hemofilter facing a chamber through which the blood flows. 13. The method according to claim 12, wherein upon termination of said blood purification, the limiting membrane is dissolved by changing a relation of said infusion rates (Q s pre, Q s post) of said substitution solution in the blood.
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Kelly, Thomas; Childers, Robert W.; Busby, Don; Roger, Rodolfo; El Sayyid, Waleed Mutasem; Din, Shahid, Medical fluid pump valve integrity test methods and systems.
Norris, Michael G.; Scarpaci, Jacob W.; Bryant, Jr., Robert J.; Spencer, Geoffrey P.; Hibbard, David J.; Dale, James D.; Kerwin, John M.; Coll, Andrew S.; Beavers, David A.; McGill, David W.; Helmore, Simon C.; Doherty, David B.; Bolton, Edgar J.; Yoo, Jinsun; Girouard, Paul G.; Karol, Daniel S.; Singer, Daniel B.; Rushlow, Joseph P., Medical treatment system and methods using a plurality of fluid lines.
Ross, Edward Allan; Melker, Richard J., Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration.
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Distler, Carl R.; Distler, Gregory L.; Demers, Jason A.; Spencer, Geoffrey P.; Bryant, Jr., Robert J., System and method for delivering a target volume of fluid.
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