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Polyhydroxyalkanoate compositions having controlled degradation rates

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08L-067/04
출원번호 US-0403242 (2003-03-28)
발명자 / 주소
  • Martin, David P.
  • Skraly, Frank
  • Williams, Simon F.
출원인 / 주소
  • Metabolix, Inc.
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 92  인용 특허 : 33

초록

Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant

대표청구항

1. A biocompatible polymeric device for implantation or injection into a patient in need thereof comprising a biocompatible and porous polyhydroxyalkanoate, wherein the degradation rate is controlled by the porosity of the polyhydroxyalkanoate at the surface of the device, andwherein the mass loss,

이 특허에 인용된 특허 (33)

  1. Williams, Simon F., Bioabsorbable, biocompatible polymers for tissue engineering.
  2. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers.
  3. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  4. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  5. Dehennau Claude (Waterloo BEX) Depireux Thierry (Waterloo BEX) Fleche Guy (Hazebrouck FRX) Gosset Serge (Lestrem FRX) Videau Didier (Lille FRX), Biodegradable moulding compositions comprising a starch, a biodegradable polyester, and a salt of a hydroxycarboxylic ac.
  6. Mao, Hai-Quan; Leong, Kam W.; Dang, Wenbin; Lo, Hungnan; Zhao, Zhong; Nowotnik, David P.; English, James P., Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same.
  7. Hubbs John C. (Kingsport TN) Harrison Marti N. (Kingsport TN), Composition and process for the production of poly(3-hydroxyalkanoates).
  8. Unger Evan C., Compositions of lipids and stabilizing materials.
  9. Shiotani Takeshi (Kakogawa JPX) Kobayashi Genta (Takasago JPX), Copolymer and method for production thereof.
  10. Sinclair Richard G. (Columbus OH) Lipinsky Edward S. (Worthington OH), Degradable polymer composition.
  11. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Gene encoding bacterial acetoacetyl-COA reductase.
  12. Asrar Jawed ; Shah Devang T. ; Tran Minhtien, Hydroxy-terminated polyhydroxyalkanoates.
  13. Martini Francesco (Milan ITX) Perazzo Luigi (Cuneo ITX) Vietto Paolo (Milan ITX), Manufacture of polymeric products.
  14. Williams, Simon F.; Martin, David P.; Skraly, Frank A., Medical devices and applications of polyhydroxyalkanoate polymers.
  15. Berthelsen Wendy A. (South Range MI) Stokes Kenneth B. (Minneapolis MN), Medical electrical lead employing improved penetrating electrode.
  16. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Method for producing novel polyester biopolymers.
  17. Mathiowitz Edith (Brookline MA) Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Schwaller Kirsten (Duxbury MA), Method for producing protein microspheres.
  18. Bichon Daniel,FRX ; Bussat Philippe,FRX ; Schneider Michel,CHX, Method of making polymeric gas or air filled microballoons for ultrasonic echography.
  19. Williams Simon F. (Sherborn MA) Peoples Oliver P. (Arlington MA), Methods for synthesizing oligomers containing hydroxy acid units.
  20. Peoples Oliver P. (Arlington MA) Gerngross Tillman U. (Cambridge MA) Sinskey Anthony J. (Boston MA), Overproduction and purification of soluble PHA synthase.
  21. Rutherford Denise R. (Oakdale MN) Hammar W. James (St. Paul MN) Babu Gaddam N. (Woodbury MN), Poly(b 상세보기
  • Martin, David P.; Skraly, Frank; Williams, Simon F., Polyhydroxyalkanoate compositions having controlled degradation rates.
  • Peoples Oliver P. (Arlington MA) Sinskey Anthony L. (Boston MA), Polyhydroxyalkanoate polymerase.
  • Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Polyhydroxybutyrate polymerase.
  • Witholt Bernard (Eelde NLX) Lageveen Roland G. (Groningen NLX), Process for producing polyesters by fermentation: a process for producing optically active carboxylic acids and esters:.
  • Makinen Ralph W. (Erie PA) Rickloff James R. (Erie PA), Process for the continuous preparation of sterile, depyrogenated solutions.
  • Bellis Harold E. (Wilmington DE), Rapidly degradable poly (hydroxyacid) compositions.
  • Schmitt Edward Emil (Norwalk CT) Epstein Martin (Norwalk CT), Reducing capillarity of polyglycolic acid sutures.
  • Williams Simon F. ; Martin David P. ; Gerngross Tillman ; Horowitz Daniel M., Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation.
  • Gogolewski Sylwester (Alvaneu CHX) Perren Stephan M. (Davos CHX), Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor.
  • Holmes Paul A. (Northallerton GBX) Lim Guan B. (Stockton-on-Tees GBX), Separation process.
  • Martini Francesco (Milan ITX) Perazzo Luigi (Cuneo ITX) Vietto Paolo (Milan ITX), Sheets materials of HB polymers.
  • Lehmann Leonard T. (Fairfield CT), Surgical filament coating.
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