Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in
Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.
대표청구항▼
1. A coating, comprising the product of the reaction of:a silane having at least one functional group selected from the group consisting of an isocyanate, an isothiocyanate, an ester, an anhydride, an acyl halide, an alkyl halide, an epoxide and an aziridine; anda biopolymer,wherein said product is
1. A coating, comprising the product of the reaction of:a silane having at least one functional group selected from the group consisting of an isocyanate, an isothiocyanate, an ester, an anhydride, an acyl halide, an alkyl halide, an epoxide and an aziridine; anda biopolymer,wherein said product is directly coated onto a surface of a medical device by covalent attachment of a silicon atom to said medical device. 2. The coating of claim 1, wherein said functional group is an isocyanate. 3. The coating of claim 2, wherein said biopolymer is heparin-tridodecylmethylammonium chloride. 4. The coating of claim 1, wherein said biopolymer is a complex selected from the group consisting of heparin-tridodecylmethylammonium chloride, heparin-benzalkonium chloride, heparin-stearalkoniun chloride, heparin-poly-N-vinyl-pyrrolidone, heparin-lecithin, heparin-didodecyldimethylammonium bromide, heparin-pyridinium chloride, and heparin-synthetic glycolipid complex. 5. The coating of claim 1, wherein said biopolymer has hydroxyl or amine functional groups. 6. The coating of claim 1, wherein said biopolymer comprises heparin. 7. The coating of claim 5, wherein said biopolymer is provided in a form capable of dissolving in an organic solvent. 8. The coating of claim 1, wherein the biopolymer provides thromboresistance. 9. The coating of claim 1, wherein said biopolymer is heparin-tridodecylmethylammonium chloride. 10. The coating of claim 1, further comprising at least one additive selected from the group consisting of wetting agents, surface active agents and film forming agents. 11. The coating of claim 1, wherein the silane has an organic chain between isocyanate and silane functional groups. 12. A coating, consisting essentially of the product of the reaction of:a silane having at least one functional group selected from the group consisting of an isocyanate, an isothiocyanate, an ester, an anhydride, an acyl halide, an alkyl halide, an epoxide and an aziridine; anda biopolymer,wherein said product is directly bonded to a surface of a medical device. 13. The coating of claim 12, wherein said functional group is an isocyanate. 14. The coating of claim 13, wherein said biopolymer is heparin-tridodecylmethylammonium chloride. 15. The coating of claim 12, wherein said biopolymer is a complex selected from the group consisting of heparin-tridodecylmethylammonium chloride, heparin-benzalkonium chloride, heparin-stearalkonium chloride, heparin-poly-N-vinyl-pyrrolidone heparin-lecithin, heparin-didodecyldimethylammonium bromide, heparin-pyridinium chloride, and heparin-synthetic glycolipid complex. 16. The coating of claim 12, wherein said biopolymer has hydroxyl or amine functional groups. 17. The coating of claim 12, wherein said biopolymer comprises heparin. 18. The coating of claim 12, wherein said biopolymer is provided in a form capable of dissolving in an organic solvent. 19. The coating of claim 12, wherein the biopolymer provides thromboresistance. 20. The coating of claim 12, wherein said biopolymer is heparin-tridodecylmethylammonium chloride. 21. The coating of claim 12, further comprising at least one additive selected from the group consisting of wetting agents, surface active agents and film forming agents. 22. The coating of claim 12, wherein said silane has an organic chain between isocyanate and silane functional groups. 23. The coating of claim 1, wherein said silane and said biopolymer are reacted in a common solvent. 24. The coating of claim 23, wherein said solvent is an anhydrous organic solvent. 25. The coating of claim 24, wherein said solvent is tetrahydrofuran. 26. The coating of claim 12, wherein said silane and said biopolymer are reacted in a common solvent. 27. The coating of claim 26, wherein said solvent is an anhydrous organic solvent. 28. The coating of claim 27, wherein said solvent is tetrahydrofuran. 29. The coating of claim 23, wherein said functional group is an isothiocyanate, said biopolymer is heparin-tridod ecylmethylammonium chloride, and said organic solvent is tetrahydrofuran. 30. The coating of claim 26, wherein said functional group is an isothiocyanate, said biopolymer is heparin-tridodecylmethylammonium chloride, and said organic solvent is tetrahydrofuran.
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