초록

The invention refers to a new process for preparing coated crystals by coating crystal template particles with alternating layers of oppositely charged polyelectrolytes and/or nanoparticles.

대표청구항 ▼

1. A process for preparing coated crystals comprising the steps:a. providing a dispersion of bio-crystal template particles in a solvent andb. coating said particles with a multilayer comprising alternating layers of oppositely charged polyelectrolytes and/or nanoparticles. 2. The process of claim 1

1. A process for preparing coated crystals comprising the steps:a. providing a dispersion of bio-crystal template particles in a solvent andb. coating said particles with a multilayer comprising alternating layers of oppositely charged polyelectrolytes and/or nanoparticles. 2. The process of claim 1, wherein said bio-crystal particles are protein crystals, peptide crystals, nucleic acid crystals, lipid based crystals, carbohydrate crystals or crystals from low molecular weight materials. 3. The process of claim 2, wherein said protein crystals are selected from antibody crystals, enzyme crystals, virus capsid protein crystals, S-layer protein crystals, glycoprotein crystals, receptor protein crystals and cytostolic protein crystals. 4. The process of claim 1, wherein said bio-crystal template particles are selected from the group consisting of crystalline bio-material, crystalline organic material, crystalline inorganic material and mixtures thereof. 5. The process of claim 4, wherein the crystalline or organic material is selected from crystalline drugs, crystalline vitamins, crystalline nutrients, crystalline hormones, crystalline growth factors, crystalline pesticides and crystalline antibiotics. 6. The process of claim 1, wherein the bio-crystal template is a single crystal materials or an amorphous crystal material. 7. The process of claim 1, wherein said bio-crystal template particles have an average diameter of 500 μm or less. 8. The process of claim 7, wherein said bio-crystal template particles have an average diameter of 50 μm or less. 9. The process of claim 1, wherein said polyelectrolytes are linear models. 10. The process of claim 1, wherein said polyelectrolytes are selected from inorganic, organic and biological polyelectrolytes and mixtures thereof. 11. The process of claim 10, wherein the organic polyelectrolyte is a polymer selected from biodegradeable polymers, fluorescently labeled polymers, conducting polymers, liquid crystal polymers, photoconducting polymers, photochromic polymers, and copolymers and/or mixtures thereof. 12. The process of claim 10, wherein the biological polyelectrolyte is a polymer selected from polyamino acids, polycarbohydrates, polynucleotides and modified biopolymers. 13. The process of claim 10, wherein the inorganic polyelectrolyte is a polymer based on polysilanes, polysilanoles, polyphosphazanes, polysulfazenes, polysulfides and polyphosphates. 14. The process of claim 1, wherein said nanoparticles have an average diameter of from 1 to 100 nm. 15. The process of claim 1, wherein said nanoparticles are selected from inorganic, organic and biological particles and mixtures thereof. 16. The process of claim 15, wherein said nanoparticles are selected from particles which provide targeting properties. 17. The process of claim 16, wherein said nanoparticles are particles having magnetic properties. 18. The process of claim 16, wherein said nanoparticles are immunoglobins or receptor ligands. 19. The process of claim 15, wherein said nanoparticles are particles having magnetic properties. 20. The process of claim 15, wherein said nanoparticles are immunoglobins or receptor ligands. 21. The process of any one of claim 15 to 20 , 17 , or 18 , wherein the inorganic nanoparticles are ceramic particles, magnetic particles, magneto-optical particles, nitridic ceramic particles, carbidic ceramic particles, metallic particles, and/or sulfur or selenium-containing particles. 22. The process of any one of claim 15 to 20 , 17 , or 18 , wherein the organic or biological nanoparticles are macromolecules and/or targeting molecules. 23. The process of claim 1, wherein said solvent is selected from aqueous solvents, organic solvents and mixed aqueous/organic solvents. 24. The process of claim 1 further comprising the step:c. at least partially solubilizing the encapsulated bio-crystal. 25. The process of claim 24, wherein said solubilization is carried out by adjustment of solvent, pH, temperature and/or salt conditions. 26. The process of claim 1 further comprising the step:d. rupturing the polyelectrolyte/nanoparticle shell. 27. The process of claim 1 further comprising the step:e. at least partially disintegrating encapsulated bio-crystals. 28. Coated bio-crystal particle having a core which is a crystal template particle and a multilayer shell comprising alternating layers of oppositely charged polyelectrolytes and/or nanoparticles. 29. Coated bio-crystal particle having a core comprising an at least partially solubilized crystal template particle and a multilayer shell comprising alternating layers of oppositely charged nanoparticles and/or polyelectrolytes. 30. The particle of claim 28 or 29 having an average diameter of 50 μm or less. 31. A hollow shell obtainable by disintegrating the template particle of the coated particle of claim 30. 32. The use of the particle according to claim 30 as a system for targeted delivery and/or controlled release of crystallizable biomolecules. 33. A hollow shell obtainable by disintegrating the template particle of the coated particle of claim 28, or 29 . 34. The use of the particle according to claim 28 or 29 as a system for targeted delivery and/or controlled release of crystallizable biomolecules.