The invention relates to a substantially non-colloidal solution made by combining ingredients comprising (a) water; (b) a source of free silver ions; and (c) a substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent.
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1. A composition comprising (1) water, (2) a silver complex, wherein the silver complex comprises silver complexed with a complexing agent, and (3) a counter-ion; wherein the composition is a substantially non-colloidal soultion, wherein the complexing agent is substantially non-toxic, substantially
1. A composition comprising (1) water, (2) a silver complex, wherein the silver complex comprises silver complexed with a complexing agent, and (3) a counter-ion; wherein the composition is a substantially non-colloidal soultion, wherein the complexing agent is substantially non-toxic, substantially thiol-free, and substantially water-soluble and comprises one or more amino acids and/or hydroxy carboxylic acids; wherein the molar ratio of complexing agent to silver is greater than one; wherein the counter-ion comprises one or more alkali metals and/or alkaline earth metals; and wherein the silver concentration does not exceed about 10,000 ppm.2. The composition of claim 1, wherein the composition possesses less than ten weight percent of free silver based on the weight of total silver.3. The composition of claim 1, wherein the composition possesses less than one weight percent of free silver based on the weight of total silver.4. The composition of claim 1, wherein the composition possesses less than one-tenth of a percent by weight of free silver based on the weight of total silver.5. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:1.5 to 1:200.6. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:1.5 to 1:50.7. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:2 to 1:20.8. The composition of claim 1, wherein when the complexing agent comprises one or more amino acids, the amino acid comprises glycine, alanine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tryptophan, serine, threonine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, and/or histidine.9. The composition of claim 1, wherein when the complexing agent comprises one or more hydroxy carboxylic acids, the hydroxy carboxylic acid comprises glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, and/or mandelic acid.10. The composition of claim 1, wherein the counter-ion comprises potassium and/or calcium.11. The composition of claim 1, wherein the silver concentration is about 10 ppm of silver to about 10,000 ppm of silver.12. The composition of claim 1, wherein the silver concentration is about 20 ppm of silver to about 10,000 ppm of silver.13. The composition of claim 1, wherein the silver concentration is about 50 ppm of silver to about 10,000 ppm of silver.14. The composition of claim 1, wherein the silver concentration is about 100 ppm of silver to about 10,000 ppm of silver.15. A composition comprising (1) water, (2) a silver complex, wherein the silver complex comprises silver complexed with citrate, citric acid or a combination thereof, and (3) a counter-ion; wherein the composition is a substantially non-colloidal soultion; wherein the complexing agent is substantially non-toxic, substantially thiol-free, and substantially water-soluble; wherein the molar ratio of complexing agent to silver is greater than one; wherein the counter-ion comprises one or more alkali metals and/or alkaline earth metals; and wherein the silver concentration does not exceed about 10,000 ppm.16. The composition of claim 15, wherein the citrate comprises dibasic citrate.17. The composition of claim 15, wherein silver is complexed with citric acid and tripotassium citrate.18. The composition of claim 15, wherein the composition possesses less than ten weight percent of free silver based on the weight of total silver.19. The composition of claim 15, wherein the composition possesses less than one weight percent of free silver based on the weight of total silver.20. The composition of claim 15, wherein the composition possesses less than one-tenth of a percent by weight percent of free silver based on the weight of total silver.21. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:1.5 to 1:200.22. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:1.5 to 1:50.23. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:2 to 1:20.24. The composition of claim 15, wherein the counter-ion comprises potassium and/or calcium.25. The composition of claim 15, wherein the silver concentration is about 10 ppm of silver to about 10,000 ppm of silver.26. The composition of claim 15, wherein the silver concentration is about 20 ppm of silver to about 10,000 ppm of silver.27. The composition of claim 15, wherein the silver concentration is about 50 ppm of silver to about 10,000 ppm of silver.28. The composition of claim 15, wherein the silver concentration is about 100 ppm of silver to about 10,000 ppm of silver.29. The composition of claim 15, wherein the counter-ion comprises potassium and/or calcium.30. A method for treating a disease or condition in a human subject, comprising administering to a human subject in need thereof an effective amount of the composition of any one of claims 1-29, wherein the disease or condition is selected from the group consisting of conjunctivitis, acne, lymphatic cancer, flu, eye infection, burn, urinary tract infection, gum infection and vaginal infection.
Hayakawa Makoto,JPX ; Watanabe Toshiya,JPX ; Kimura Tamon,JPX ; Kanno Mitsuyoshi,JPX ; Norimoto Keiichiro,JPX, Antimicrobial solid material, process for producing the same, and method of utilizing the same.
Maurer Gerald L. (Fairfield OH) Shringarpurey Sudhir K. (Cincinnati OH), Complexes of heavy metal ions and polyfunctional organic ligands used as antimicrobial agents.
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