초록 ▼

A method of diagnosing prostate cancer in a human patient comprising the steps of obtaining a sample containing nucleic acid and/or protein from prostate cells of a patient, and determining whether the sample contains a level of Pax 2 nucleic acid or protein associated with prostate cancer. A method

A method of diagnosing prostate cancer in a human patient comprising the steps of obtaining a sample containing nucleic acid and/or protein from prostate cells of a patient, and determining whether the sample contains a level of Pax 2 nucleic acid or protein associated with prostate cancer. A method of treating prostate cancer comprising the step of administering to the patient an agent which selectively prevents the function of Pax 2. A genetic construct comprising a nucleic acid encoding a molecule capable of preventing the function of Pax 2 expressed in a prostate cell.

대표청구항 ▼

1. A method of diagnosing prostate cancer in a human patient comprising the steps of:(i) obtaining a sample containing mRNA from a test sample of prostate cells from the patient; (ii) detecting the presence or absence of Pax 2 mRNA expession which is associated with prostate cancer; and (iii) diagno

1. A method of diagnosing prostate cancer in a human patient comprising the steps of:(i) obtaining a sample containing mRNA from a test sample of prostate cells from the patient; (ii) detecting the presence or absence of Pax 2 mRNA expession which is associated with prostate cancer; and (iii) diagnosing the presence of prostate cancer in the event that the presence of Pax 2 mRNA expression which is associated with prostate cancer is detected in the test sample. 2. A method of identifying the presence of metastatic prostate cancer in a human patient comprising the steps of:(i) obtaining a sample containing mRNA from a test sample of prostate cells from the patient; and (ii) detecting the presence or absence of Pax 2 mRNA expression which is associated with metastatic prostate cancer; and (iii) diagnosing the presence of metastatic prostate cancer in the event that the presence of Pax 2 mRNA expression which is associated with metastatic prostate cancer is detected in the test sample. 3. A method according to any of claims 1 or 2 wherein the cancer is invasive.4. A method according to any of claims 1, or 2 wherein the sample contains mRNA and the amount of Pax 2 mRNA is measured by contacting the mRNA with a nucleic acid which hybridises selectively to Pax 2 mRNA.5. A method according to claim 4 wherein the nucleic acid which hybridises is detectably labelled.6. A method according to claim 4 wherein the nucleic acid which selectively hybridises is detectably labelled.7. A method according to claim 4 wherein the nucleic acid which selectively hybridises is suitable for use in a nucleic acid amplification reaction.8. A method according to any of claims 1 or 2 wherein the sample is a sample of the tissue in which prostate cancer is suspected or in which prostate cancer may be or has been found, or is a sample of urine, semen, blood or lymph fluid containing cells from said tissue.9. A method according to claim 1 wherein no Pax 2 mRNA is detectable in the sample of non-cancerous cells.10. A method according to claim 2 wherein no Pax 2 mRNA is detectable in the sample of non-cancerous cells.11. A method according to any one of claims 1, 2, 9 or 10, wherein the cancer is invasive.12. A method according to any one of claims 1, 2, 9 or 10, wherein the sample contains mRNA and the amount of Pax 2 mRNA is measured by contacting the mRNA with a nucleic acid which hybridizes selectively to Pax 2 mRNA.13. A method according to claim 12 wherein the nucleic acid which hybridizes is detectably labeled.14. A method according to claim 12 wherein the nucleic acid which selectively hybridizes is detectably labeled.15. A method according to claim 12 wherein the nucleic acid which selectively hybridizes is suitable for use in a nucleic acid amplification reaction.16. A method according to any one of claims 1, 2, 9 or 10, wherein the sample is a sample of the tissue in which prostate cancer is suspected or in which prostate cancer may be or has been found, or is a sample of urine, semen, blood or lymph fluid containing cells from said tissue.