초록

This invention provides medical devices and methods for extracting cellular samples from a bone cavity.

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1. A device for extracting material from a bone cavity, the device comprising:a housing comprising a lumen running a length of the housing, a first lumen aperture at a first end of the housing, and a second lumen aperture at a second region of the housing; a plunger body, wherein the plunger body is

1. A device for extracting material from a bone cavity, the device comprising:a housing comprising a lumen running a length of the housing, a first lumen aperture at a first end of the housing, and a second lumen aperture at a second region of the housing; a plunger body, wherein the plunger body is slideably positioned within and extends at least a part of the length of the lumen; one or more filaments coupled to a first end of the plunger and positioned proximal to the first end of the housing; a handle coupled to a second end of the plunger, wherein the handle extends beyond the second region of the housing; and an aspiration tube cojoined to a portion of the housing, wherein the aspiration tube comprises a first aspiration aperture proximal to the first lumen aperture. 2. The device of claim 1, wherein the housing further comprises a piercing mechanism at the first end of the housing proximal to the first lumen aperture.3. The device of claim 1, wherein the first lumen aperture and the first aspiration aperture are adjacently positioned to provide a piercing mechanism for insertion of the apertures into the bone cavity.4. The device of claim 1, wherein the housing further comprises a stop at the second region of the housing.5. The device of claim 1, wherein the plunger comprises a screw-threaded plunger portion and the lumen comprises inner screw threads for metering insertion of the filament into the bone cavity.6. The device of claim 1, wherein the one or more filaments further comprises a stabilizing wire.7. The device of claim 6, wherein the stabilizing wire further comprises a pointed region.8. The device of claim 1, wherein a member of the one or more filaments comprises a rigid piece of plastic or metal having one or more looped extensions.9. The device of claim 8, wherein the metal comprises stainless steel, surgical stainless steel, or titanium.10. The device of claim 8, wherein the rigid piece comprises a shape memory wire.11. The device of claim 8, wherein the filament member comprises a cutting edge.12. The device of claim 1, wherein the filament member comprises one or more brush-like members.13. The device of claim 1, wherein the handle comprises an ergonomically-shaped member.14. The device of claim 1, wherein the handle comprises a knob.15. The device of claim 1, wherein the aspiration tube further comprises a vacuum mechanism positioned at a second aspiration aperture.16. The device of claim 15, wherein the vacuum mechanism comprises a syringe.17. The device of claim 15, wherein the vacuum mechanism comprises a vacuum pump.18. The device of claim 15, further comprising a collection device coupled to the vacuum mechanism of the aspiration tube.19. The device of claim 1, wherein the housing comprises a multi-lumen structure encompassing both the lumen and the aspiration tube.20. The device of claim 1, further comprising a sleeve encompassing the housing and the aspiration tube.21. A device for extracting material from a bone cavity, the device comprising:a housing comprising a lumen running a length of the housing, a first lumen aperture at a first end of the housing, and a second lumen aperture at a second region of the housing; a plunger body, wherein the plunger body is slideably positioned within and extends at least a part of the length of the lumen; one or more filaments coupled to a first end of the plunger and proximal to the first end of the housing; a handle coupled to a second end of the plunger, wherein the handle extends beyond the second region of the housing; and an aspiration port in fluid contact with the lumen, by which bone cavity material disrupted by the one or more filaments can be extracted. 22. A method for extracting contents from a bone cavity, the method comprising:inserting a proximal end of an extraction device into the bone cavity; extending a filament from the device into the bone cavity; rotating the filament and disrupting a localized cellular matrix; and aspirating components of the disrupted matrix, thereby extracting contents from the bone cavity. 23. The method of claim 22, wherein inserting the proximal end of the extraction device comprises:placing the proximal end of the device against a bone surface, wherein the proximal end of the device comprises a cutting mechanism; and pressing the cutting mechanism against the bone surface and entering the bone cavity. 24. The method of claim 23, further comprising:rotating the proximal end of the device within the bone cavity prior to extending the filament. 25. The method of claim 22, wherein extending the filament comprises:grasping the plunger handle and moving the handle toward the proximal end of the housing, thereby moving a plunger body along a lumen and propelling the filament out of a first lumen aperture and into the bone cavity. 26. The method of claim 22, wherein extending the filament comprises:rotating the plunger handle, thereby moving the a screw-threaded plunger body along a screw threaded lumen and shifting the filament out of the first lumen aperture and into the bone cavity. 27. The method of claim 22, wherein rotating the filament comprises turning the plunger handle.28. The method of claim 22, wherein rotating the filament comprises coupling the plunger body to a power shaft of a dental handpiece.29. The method of claim 22, wherein aspirating the released cavity contents comprises coupling a vacuum mechanism to the device.30. The method of claim 22, wherein extending and rotating the filament are performed concomitantly.31. The method of claim 22, wherein rotating the filament and aspirating the released cavity contents are performed concomitantly.32. The method of claim 22, wherein the bone cavity comprises a cavity in a bone selected from the group consisting of an iliac crest, a jaw bone, a sternum, and a tibia.