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Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • G01N-033/543
  • C07H-021/02
  • C07H-021/04
출원번호 US-0794851 (1997-02-04)
발명자 / 주소
  • Barany, Francis
  • Barany, George
  • Hammer, Robert P.
  • Kempe, Maria
  • Blok, Herman
  • Zirvi, Monib
출원인 / 주소
  • Cornell Research Foundation, Inc.
  • Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
  • Regents of the University of Minnesota
대리인 / 주소
    Nixon Peabody LLP
인용정보 피인용 횟수 : 199  인용 특허 : 33

초록

The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detectio

대표청구항

1. A method for identifying one or more of a plurality of sequences differing by one or more single-base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences comprising:providing a sample potentially containing one or more target nucleotide sequences with a

이 특허에 인용된 특허 (33)

  1. Chakraborty Prasanta R. (Scotch Plains NJ) Elbrecht Alex (Watchung NJ) Dashkevicz Michael (Jamesburg NJ) Feighner Scott D. (Scotch Plains NJ) Liberator Paul A. (Jackson NJ) Profous-Juchelka Helen (St, Eimeria brunetti 16s rDNA probes.
  2. Zaun Peter (Libertyville IL) Bouma Stanley R. (Grayslake IL) Gordon Julian (Lake Bluff IL) Kotlarik John J. (Vernon Hills IL), Apparatus and method for amplifying and detecting target nucleic acids.
  3. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
  4. Fodor Stephen P.A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Arrays of materials attached to a substrate.
  5. Ekins Roger P. (Department of Molecular Endocrinology University College and Middlesex School of Medicine Mortimer Street London W1N 8AA GBX) Chu Frederick W. (Department of Molecular Endocrinology U, Binding assay employing labelled reagent.
  6. Reddy M. Parameswara (Brea CA) Sternberg James C. (Fullerton CA), Compositions and methods for use in detection of analytes.
  7. Barany Francis ; Lubin Matthew, Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions.
  8. Barany, Francis; Gerry, Norman P.; Witowski, Nancy E.; Day, Joseph; Hammer, Robert P.; Barany, George, Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays.
  9. Whiteley Norman M. (San Carlos CA) Hunkapiller Michael W. (San Carlos CA) Glazer Alexander N. (Orinda CA), Detection of specific sequences in nucleic acids.
  10. Brush Charles K. (Whitefish Bay WI), Fluorescein labelled phosphoramidites.
  11. Shuber Anthony P., High throughput screening method for sequences or genetic alterations in nucleic acids.
  12. Lichtenwalter Kay (San Jose CA) Melton ; Jr. Hewlett E. (Sunnyvale CA), Holographic based bio-assay.
  13. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of an array of polymers.
  14. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
  15. Brenner Sydney (Cambridge GB2), Massively parallel sequencing of sorted polynucleotides.
  16. Matson Robert S. (Orange CA) Coassin Peter J. (San Juan Capistrano CA) Rampal Jang B. (Yorba Linda CA) Southern Edwin M. (Kidlington GB2), Method and apparatus for creating biopolymer arrays on a solid support surface.
  17. Fodor Stephen P. A. (Palo Alto CA) Mazzola Laura T. (Redwood City CA), Method and apparatus for measuring binding affinity.
  18. Silver Jonathan (Bethesda MD) Feinstone Stephen (Washington DC), Method for amplifying unknown nucleic acid sequences.
  19. Landegren Ulf (Pasadena CA) Hood Leroy (Pasadena CA), Method of detecting a nucleotide change in nucleic acids.
  20. Wallace R. Bruce, Method of detecting and discriminating between nucleic acid sequences.
  21. Drmanac Radoje T. (Belgrade YUX) Crkvenjakov Radomir B. (Belgrade YUX), Method of sequencing by hybridization of oligonucleotide probes.
  22. Drmanac Radoje T. (Zvecanska 46 Beograd 11000) Crkvenjakov Radomir B. (Bulevar JNA 118 Beograd YUX 11000), Method of sequencing of genomes by hybridization of oligonucleotide probes.
  23. Fino James R. (Antioch IL), Methods, kits, and reactive supports for 3′labeling of oligonucleotides.
  24. Church George M. (Brookline MA) Kieffer-Higgins Stephen G. (Dorchester MA), Parallel sequential reactor.
  25. Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Photolabile reagents for incorporation into oligonucleotide chains.
  26. Sapolsky Ronald J. ; Lipshutz Robert J., Polymorphism detection.
  27. Grossman Paul D. (Burlingame CA) Fung Steven (Palo Alto CA) Menchen Steven M. (Fremont CA) Woo Sam L. (Redwood City CA) Winn-Deen Emily S. (Foster City CA), Probe composition containing a binding domain and polymer chain and methods of use.
  28. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
  29. Ronai Zeey A. (Montebello NY), Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method.
  30. McGall Glenn H. (Mountain View CA) Fodor Stephen P. A. (Palo Alto CA) Sheldon Edward L. (Menlo Park CA), Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces.
  31. Barany Francis (New York NY) Zebala John (New York NY) Nickerson Deborah (Seattle WA) Kaiser ; Jr. Robert J. (Seattle WA) Hood Leroy (Seattle WA), Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease.
  32. Lizardi Paul M.,MXX ; Caplan Michael, Unimolecular segment amplification and sequencing.
  33. Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA), Very large scale immobilized polymer synthesis.

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  128. Hofstadler, Steven A.; Hall, Thomas A.; Ecker, David J.; Blyn, Lawrence B.; Eshoo, Mark W.; Samant, Vivek; White, Neill, Methods for rapid forensic analysis of mitochondrial DNA.
  129. Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Hall, Thomas A.; Jiang, Yun; Hannis, James C.; White, Neil; Samant, Vivek; Eshoo, Mark W.; Drader, Jared J., Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy.
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  133. Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Methods for rapid identification of pathogens in humans and animals.
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  145. Fallon, Joan M., Methods for treating pervasive development disorders.
  146. Zhou, Wei; Mei, Rui; Matsuzaki, Hajime, Methods of targeted sequencing.
  147. Fallon, Joan M., Methods of treating and diagnosing Parkinson's disease and related dysautonomic disorders.
  148. Fallon, Joan M., Methods of treating and diagnosing Parkinsons disease and related dysautonomic disorders.
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  150. Fallon, Joan; Heil, Matthew; Szigethy, James; Fallon, James, Methods of treatment of schizophrenia.
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  152. Chen, Caifu; Tan, Ruoying, Methods, compositions, and kits for detecting allelic variants.
  153. Chen, Caifu; Tan, Ruoying, Methods, compositions, and kits for detecting allelic variants.
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  155. Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C.; Oberkramer, Kevin S.; Bergold, Ronald K., Microplate handling systems and related computer program products and methods.
  156. Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Mixing cartridges, mixing stations, and related kits, systems, and methods.
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  161. Struble, Craig; Oliphant, Arnold; Wang, Eric, Non-invasive fetal sex determination.
  162. Oliphant, Arnold; Wang, Eric; Struble, Craig, Noninvasive detection of fetal aneuploidy in egg donor pregnancies.
  163. Fallon, Joan M., Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same.
  164. Fallon, Joan M., Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same.
  165. Fallon, Joan M., Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same.
  166. Fallon, Joan M., Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same.
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  180. Andregg, William; Andregg, Michael, Sequencing nucleic acid polymers with electron microscopy.
  181. DiPerna, Paul M., Slideable flow metering devices and related methods.
  182. Brown, David, Solute concentration measurement device and related methods.
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  191. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
  192. Ecker, David J.; Hofstadler, Steven A.; Hall, Thomas A.; Sannes-Lowery, Kristin, Systems and methods for rapid identification of nucleic acid variants.
  193. Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared; Bergold, Ronald K.; Miller, Robert D.; Oberkramer, Kevin S., Systems for bioagent indentification.
  194. Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Systems for rapid identification of pathogens in humans and animals.
  195. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
  196. Ecker, David J.; Eshoo, Mark W., Targeted whole genome amplification method for identification of pathogens.
  197. DiPerna, Paul M., Two chamber pumps and related methods.
  198. Fallon, Joan M.; Feltenstein, Richard, Use of lactulose in the treatment of autism.
  199. Fallon, Joan M.; Feltenstein, Richard, Use of lactulose in the treatment of autism.
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