IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0997213
(2001-11-27)
|
우선권정보 |
EP-0202140 (1997-07-11) |
발명자
/ 주소 |
- van Damme, Hendrik Sibolt
- Kreuwel, Hermanus Johannes Maria
- Kievits, Tim
- van Beuningen, Marinus Gerardus Johannus
- Boender, Pieter Jacob
|
출원인 / 주소 |
- PamGene International B.V.
|
대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
7 |
초록
▼
Disclosed is a device useful for performing an assay comprising a substrate having interconnecting channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, th
Disclosed is a device useful for performing an assay comprising a substrate having interconnecting channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels. Similar devices are also useful for chemical synthesis. Assay and chemical synthesis methods are also disclosed, as are kits for performing the assays or chemical syntheses.
대표청구항
▼
1. A device for performing an assay, which device comprises a substrate having interconnected channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of bind
1. A device for performing an assay, which device comprises a substrate having interconnected channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte, wherein the substrate is an electrochemically manufactured metal oxide membrane and the first binding substance is within the interconnected channels in the substrate.2. The device of claim 1, wherein the metal oxide membrane is comprised of aluminium oxide.3. The device of claim 1, wherein the first binding substance is covalently bound to the substrate.4. The device of claim 1, wherein the first binding substance is selected from the group consisting of an oligopeptide, a polypeptide, an oligonucleotide, a polynucleotide, a hapten, and a ligand for a receptor.5. The device of claim 4, wherein the first binding substance is an oligopeptide.6. The device of claim 5, wherein the oligopeptide comprises an immunogenic epitope.7. The device of claim 5, wherein the oligopeptide comprises a portion of an HIV protein.8. The device of claim 4, wherein the first binding substance is a polypeptide.9. The device of claim 8, wherein the first binding substance is an antibody or an enzyme.10. The device of claim 4, wherein the first binding substance is an oligonucleotide.11. The device of claim 10, wherein the first binding substance comprises a portion of an HIV genome.12. A kit comprising (a) the device of claim 1, and (b) a detection means for determining whether binding has occurred between the first binding substance and the analyte.13. The kit of claim 12 wherein the detection means comprises a second binding substance provided with a label.14. The kit of claim 13, wherein the label is capable of inducing a colored or infrared or ultraviolet reaction product, or capable of bio- or chemo- or photoluminescence.15. The kit of claim 14, wherein the detection means uses an enzymatic reaction.16. A device for performing a chemical synthesis, which device comprises a substrate having interconnected channels, said channels opening out on a surface, the channels in at least one area of the surface for reagent application being provided with a first reacting substance capable of reacting with a second reacting substance, wherein the substrate is an electrochemically manufactured metal oxide membrane and the first reacting substance is within the interconnected channels in the substrate.17. The device of claim 16, wherein the first reacting substance is a polymer.18. The device of claim 16, wherein the first reacting substance is covalently bound to the substrate.19. The device of claim 17, wherein the polymer is capable of covalently binding to an organic molecule of less than 1000 Dalton.20. The device of claim 17, wherein the polymer is capable of covalently binding to a modified amino acid useful for oligopeptide synthesis.21. The device of claim 17, wherein the polymer is capable of covalently binding to a modified nucleotide useful for oligonucleotide synthesis.
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