IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0809765
(2004-03-24)
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발명자
/ 주소 |
- Weber, Jan
- Kocur, Gordon John
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출원인 / 주소 |
- Boston Scientific SciMed, Inc.
|
인용정보 |
피인용 횟수 :
159 인용 특허 :
8 |
초록
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A method for electrostatic spray-coating a medical device having a tubular wall, such as a stent, having an inner surface, an outer surface and openings therein. The tubular wall is grounded or electrically charged, and an electrically charged conductive core wire is located axially through the cent
A method for electrostatic spray-coating a medical device having a tubular wall, such as a stent, having an inner surface, an outer surface and openings therein. The tubular wall is grounded or electrically charged, and an electrically charged conductive core wire is located axially through the center of the stent. An electrical potential is applied to the conductive core wire to impart an electrical charge to the conductive core wire. The tubular wall is exposed to an electrically charged coating formulation, and the electrically charged coating formulation is deposited onto a portion of the tubular wall to form a coating. The electrical potentials of the conductive core wire and tubular wall can be repeatedly alternated.
대표청구항
▼
1. A method for coating a medical device comprising a tubular wall having an inner surface, an outer surface and openings therein, wherein the method comprises:(a) grounding or electrically charging the tubular wall; (b) providing a conductive core wire located axially through the tubular wall; (c)
1. A method for coating a medical device comprising a tubular wall having an inner surface, an outer surface and openings therein, wherein the method comprises:(a) grounding or electrically charging the tubular wall; (b) providing a conductive core wire located axially through the tubular wall; (c) applying a potential to the conductive core wire to impart an electrical charge to the conductive core wire; (d) exposing the tubular wall to an electrically charged coating formulation comprising a biologically active material; and (e) depositing the coating formulation onto a portion of the tubular wall to form a coating on the tubular wall. 2. The method of claim 1, wherein the biologically active material comprises an immunosuppressant, an antiproliferative agent, or a combination thereof.3. The method of claim 2, wherein the immunosuppressant comprises sirolimus, everolimus, tacrolimus, or a combination thereof.4. The method of claim 2, wherein the antiproliferative agent comprises paclitaxel, an analog thereof, a derivative thereof, or a combination thereof.5. The method of claim 1, wherein the biologically active material comprises genetic material.6. The method of claim 1, wherein the coating formulation further comprises a polymeric material and a solvent.7. The method of claim 1, wherein the tubular wall is grounded, and the conductive core wire and the coating formulation have the same electrical charge.8. The method of claim 7, wherein the electrical charge of the coating formulation and the electrical charge of the conductive core wire are adjusted so that the charged coating formulation is deposited on the outer surface of the tubular wall and the inner surface remains substantially free of the charged coating formulation.9. The method of claim 1, wherein the tubular wall is grounded, and the conductive core wire has an electrical charge opposite that of the coating formulation.10. The method of claim 1, wherein the tubular wall comprises a geometric center, and the conductive core wire is located axially through the center of the tubular wall.11. The method of claim 1, wherein the potential applied to the conductive core wire is pulsated to cyclically impart a positive electrical charge to the conductive core wire followed by a negative electrical charge.12. The method of claim 11, wherein a positive electrical charge imparted to the conductive core wire is for a shorter duration than the negative electrical charge imparted to the conductive core wire.13. The method of claim 11, wherein the coating formulation has a positive electrical charge, and an electrical potential applied to the tubular wall is repeatedly alternated between grounded and positively charged to deposit a desired amount of the coating formulation on each portion of the tubular wall.14. The method of claim 1, wherein the conductive core wire is kept substantially free of the charged coating formulation.15. The method of claim 1, wherein the conductive core wire has two ends and one end of the conductive core wire is connected to a first bobbin and the other end is connected to a second bobbin, wherein the conductive core wire is fed from the first bobbin through the tubular wall, and wherein the conductive core wire covered with the coating formulation is removed from the tubular wall by being connected to the second bobbin.16. The method of claim 1, which further comprises directing the charged coating formulation by providing (a) a first deflector plate having a positive electrical charge and a second deflector plate having a negative electrical charge, which are placed parallel to each other and (b) applying the charged coating formulation between the plates.17. A method for coating a medical device comprising a tubular wall having an inner surface, an outer surface and openings therein, wherein the method comprises:(a) grounding or electrically charging the tubular wall; (b) providing a first core wire comprising a resistor material located axially through the tubular wall; (c) directing a current through the first core wire; (d) creating an electrically charged coating formulation comprising a biologically active material; and (e) depositing the coating formulation onto the tubular wall to form a coating on the tubular wall. 18. The method of claim 17, wherein the coating formulation further comprises a polymeric material and a solvent.19. The method of claim 17, wherein the tubular wall comprises two end sections and wherein a greater amount of coating formulation is applied to one end section than the other.20. The method of claim 17, which further comprises providing a second care wire comprising a resistor material through the tubular wall wherein the second core wire is parallel to the first core wire; and directing a second current through the second core wire in direction opposite the first current.21. The method of claim 17, wherein the first core wire is kept substantially free of the coating formulation.22. The method of claim 17, wherein the first core wire comprising two ends and one end of the first core wire is connected to a first bobbin and the other end is connected to a second bobbin, wherein the first core wire is fed from the first bobbin through the tubular wall, and wherein the first core wire covered with the coating formulation is removed from the tubular wall by being connected to the second bobbin.23. The method of claim 17, wherein the biologically active material comprises an immunosuppressant, an antiproliferative agent, or a combination thereof.24. The method of claim 23, wherein the immunosuppressant comprises sirolimus, everolimus, tacrolimus, or a combination thereof.25. The method of claim 23, wherein the antiproliferative agent comprises paclitaxel, an analog thereof, a derivative thereof, or a combination thereof.26. The method of claim 23, wherein the coating formulation further comprises a polymeric material and a solvent.27. The method of claim 17, wherein the biologically active material comprises genetic material.28. A method for coating at least a portion of a stent, wherein the stent comprises a stent wall having an inner surface, an outer surface and openings therein, wherein the method comprises:(a) grounding or electrically charging the stent wall; (b) providing a conductive core wire located axially through the stent; (c) applying a potential to the conductive core wire to impart an electrical charge to the conductive core wire; (d) exposing the stent to an electrically charged coating formulation comprising a biologically active material; and (e) depositing the charged coating formulation onto the stent portion to form a coating on the portion. 29. The method of claim 28, wherein the biologically active material comprises an immunosuppressant, an antiproliferative agent, or a combination thereof.30. The method of claim 29, wherein the immunosuppressant comprises sirolimus, everolimus, tacrolimus, or a combination thereof.31. The method of claim 29, wherein the antiproliferative agent comprises paclitaxel, an analog thereof, a derivative thereof, or a combination thereof.32. The method of claim 28, wherein the biologically active material comprises genetic material.
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