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The present invention is directed primarily to an interlinked crystalline solid polyethylene glycol composition (I-PEG) having a molecular weight of at least 20 kDa and a melting temperature of at least 40° C. and its use as an absorbable device having hydrolabile ester or carbonate interlinks that

The present invention is directed primarily to an interlinked crystalline solid polyethylene glycol composition (I-PEG) having a molecular weight of at least 20 kDa and a melting temperature of at least 40° C. and its use as an absorbable device having hydrolabile ester or carbonate interlinks that allow in vivo dissociation of the interlinked chain into excretable, low molecular weight PEG segments.

대표청구항 ▼

1. A covalently interlinked crystalline solid polyethylene glycol composition comprising solid polyethylene glycol segments having terminal hydroxy groups and interlinks covalently connecting the solid polyethylene glycol segments, the interlinked polyethylene glycol having a melting temperature of

1. A covalently interlinked crystalline solid polyethylene glycol composition comprising solid polyethylene glycol segments having terminal hydroxy groups and interlinks covalently connecting the solid polyethylene glycol segments, the interlinked polyethylene glycol having a melting temperature of at least 40° C. and molecular weight of at least 20 kDa.2. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 wherein the solid polyethylene glycol segments have a molecular weight of at least 1 kDa.3. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 2 wherein the interlinks comprise dicarboxylate moieties.4. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 3 wherein the dicarboxylate moieties comprise the reaction product of the terminal hydroxyl groups of the polyethylene glycol segments and at least one diester of a dicarboxylic acid.5. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 4 wherein the at least one diester is selected from the group consisting essentially of diethyl oxalate, diethyl succinate, dimethyl succinate, dimethyl glutarate, diethyl glutarate, dimethyl adipate, and diethyl adipate.6. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 2 wherein the interlinks comprise carbonate moieties.7. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 6 wherein the carbonate moieties comprise the reaction product of the terminal hydroxyl groups of the polyethylene glycol segments and at least one dialkyl carbonate.8. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 7 wherein the dialkyl carbonate comprises dibutyl carbonate.9. A covalently interlinked crystalline polyethylene glycol composition comprising:solid polyethylene glycol segments having moieties derived from a cyclic monomer end-grafted onto both ends of each polyethylene glycol segment, the end-grafted polyethylene glycol segments having terminal hydroxyl groups; and interlinks covalently connecting the end-grafted polyethylene glycol segments. 10. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 9 wherein the interlinks comprise urethane moieties.11. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 10 wherein the urethane moieties comprise the reaction product of the terminal hydroxyl groups of the end-grafted polyethylene glycol segments and an aliphatic diisocyanate.12. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 11 wherein the aliphatic diisocyanate is selected from the group consisting essentially of lysine diisocyanate, 1,6-hexamethylene diisocyanate, and 1,4-tetramethylene diisocyanate.13. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 9 wherein the cyclic monomer comprises a lactone.14. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 13 wherein the lactone is selected from the group consisting essentially of caprolactone, lactide, p-dioxanone, and glycolide.15. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 9 wherein the cyclic monomer comprises a carbonate.16. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 15 wherein the carbonate comprises trimethylene carbonate.17. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 further comprising moieties derived from at least one cyclic monomer end-grafted onto both ends of the interlinked polyethylene glycol composition, the at least one cyclic monomer selected from the group consisting essentially of caprolactone, p-dioxanone, lactide, glycolide, and trimethylene carbonate.18. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 in the form of a coating on an implantable stent in a body lumen.19. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 18 wherein the implantable stent is placed in a blood vessel.20. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 in the form of an implantable stent for use in the urinogenital tract.21. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 in the form of an implantable hemodialysis device comprising a subcutaneous catheter protrusion cover.22. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 1 in the form of a hemostatic electrospun device for sealing a femoral artery hole following angioplasty.23. A covalently interlinked crystalline polyethylene glycol composition as set forth in claim 22 wherein the hemostatic device comprises chitosan.