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Polyhydroxyalkanoate compositions having controlled degradation rates

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08L-067/04
출원번호 US-0403942 (2003-03-28)
발명자 / 주소
  • Martin, David P.
  • Skraly, Frank
  • Williams, Simon F.
출원인 / 주소
  • Metabolix, Inc.
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 50  인용 특허 : 27

초록

Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant

대표청구항

1. A method for preparing a biocompatible biodegradable polyhydroxyalkanoate composition that has a controlled degradation rate under physiological conditions, wherein the mass loss, as measured bvxas chromatography, is greater than 5% over a six week period in vivo, or wherein the average molecular

이 특허에 인용된 특허 (27)

  1. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers.
  2. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  3. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  4. Dehennau Claude (Waterloo BEX) Depireux Thierry (Waterloo BEX) Fleche Guy (Hazebrouck FRX) Gosset Serge (Lestrem FRX) Videau Didier (Lille FRX), Biodegradable moulding compositions comprising a starch, a biodegradable polyester, and a salt of a hydroxycarboxylic ac.
  5. Hubbs John C. (Kingsport TN) Harrison Marti N. (Kingsport TN), Composition and process for the production of poly(3-hydroxyalkanoates).
  6. Unger Evan C., Compositions of lipids and stabilizing materials.
  7. Shiotani Takeshi (Kakogawa JPX) Kobayashi Genta (Takasago JPX), Copolymer and method for production thereof.
  8. Sinclair Richard G. (Columbus OH) Lipinsky Edward S. (Worthington OH), Degradable polymer composition.
  9. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Gene encoding bacterial acetoacetyl-COA reductase.
  10. Asrar Jawed ; Shah Devang T. ; Tran Minhtien, Hydroxy-terminated polyhydroxyalkanoates.
  11. Martini Francesco (Milan ITX) Perazzo Luigi (Cuneo ITX) Vietto Paolo (Milan ITX), Manufacture of polymeric products.
  12. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Method for producing novel polyester biopolymers.
  13. Mathiowitz Edith (Brookline MA) Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Schwaller Kirsten (Duxbury MA), Method for producing protein microspheres.
  14. Bichon Daniel,FRX ; Bussat Philippe,FRX ; Schneider Michel,CHX, Method of making polymeric gas or air filled microballoons for ultrasonic echography.
  15. Williams Simon F. (Sherborn MA) Peoples Oliver P. (Arlington MA), Methods for synthesizing oligomers containing hydroxy acid units.
  16. Peoples Oliver P. (Arlington MA) Gerngross Tillman U. (Cambridge MA) Sinskey Anthony J. (Boston MA), Overproduction and purification of soluble PHA synthase.
  17. Rutherford Denise R. (Oakdale MN) Hammar W. James (St. Paul MN) Babu Gaddam N. (Woodbury MN), Poly(b 상세보기
  • Peoples Oliver P. (Arlington MA) Sinskey Anthony L. (Boston MA), Polyhydroxyalkanoate polymerase.
  • Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Polyhydroxybutyrate polymerase.
  • Witholt Bernard (Eelde NLX) Lageveen Roland G. (Groningen NLX), Process for producing polyesters by fermentation: a process for producing optically active carboxylic acids and esters:.
  • Makinen Ralph W. (Erie PA) Rickloff James R. (Erie PA), Process for the continuous preparation of sterile, depyrogenated solutions.
  • Bellis Harold E. (Wilmington DE), Rapidly degradable poly (hydroxyacid) compositions.
  • Schmitt Edward Emil (Norwalk CT) Epstein Martin (Norwalk CT), Reducing capillarity of polyglycolic acid sutures.
  • Gogolewski Sylwester (Alvaneu CHX) Perren Stephan M. (Davos CHX), Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor.
  • Holmes Paul A. (Northallerton GBX) Lim Guan B. (Stockton-on-Tees GBX), Separation process.
  • Martini Francesco (Milan ITX) Perazzo Luigi (Cuneo ITX) Vietto Paolo (Milan ITX), Sheets materials of HB polymers.
  • Lehmann Leonard T. (Fairfield CT), Surgical filament coating.
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    1. Gonzales, Donald A.; Natale, Anthony, Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues.
    2. Gonzales, Donald A.; Natale, Anthony, Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues.
    3. Fox, William Jason; Harold, Nathan; Garcia, Antonio; Tochterman, Andrew, Bioabsorbable stent with prohealing layer.
    4. Ding, Ni; Michal, Gene; Pacetti, Stephen D., Carbon coating on an implantable device.
    5. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
    6. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
    7. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
    8. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
    9. Martin, David P.; Williams, Simon F., Compositions and devices of poly-4-hydroxybutyrate.
    10. Martin, David P.; Williams, Simon F., Compositions and devices of poly-4-hydroxybutyrate.
    11. Guo, Kai; Martin, David P., Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers.
    12. Hayes,Richard Allen, Copolyetherester compositions containing hydroxyalkanoic acids and shaped articles produced therefrom.
    13. Trollsas, Mikael; Ngo, Michael H.; Anukhin, Boris; Nikanorov, Alexander; Hossainy, Syed; Papp, John E.; Jayasinghe, Dudley; Solter, Zella, Crush recoverable polymer scaffolds.
    14. Trollsas, Mikael; Ngo, Michael H.; Anukhin, Boris; Nikanorov, Alexander; Hossainy, Syed; Papp, John E.; Jayasinghe, Dudley; Solter, Zella, Crush recoverable polymer scaffolds.
    15. Hepworth, Edward J.; Kashiwa, Corey B.; Tyrrell, Steven P., Device for maintaining patent paranasal sinus ostia.
    16. Hepworth, Edward J.; Kashiwa, Corey B.; Tyrrell, Steven P., Device for maintaining patent paranasal sinus ostia.
    17. Lenarz, Thomas; Schmitz, Klaus-Peter; Behrend, Detlef; Sternberg, Katrin; Williams, Simon; Martin, David, Drug eluting cochlear implants.
    18. Carter, Andrew J., Implants for soft and hard tissue regeneration.
    19. Williams, Simon F.; Martin, David P.; Skraly, Frank A., Medical devices and applications of polyhydroxyalkanoate polymers.
    20. Cahil, Ryan; Guo, Kai; Martin, David P.; Rizk, Said; Ho, Kicherl; Williams, Simon F., Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers.
    21. Guo, Kai; Felix, Fabio; Martin, David P., Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties.
    22. Martin, David P.; Rizk, Said; Ho, Kicherl; Williams, Simon F., Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof.
    23. Rizk, Said; Martin, David P.; Ho, Kicherl; Williams, Simon F., Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers.
    24. Trollsas, Mikael; Ngo, Michael H.; Anukhin, Boris; Nikanorov, Alexander; Hossainy, Syed; Papp, John E.; Jayasinghe, Dudley; Solter, Zella, Method of crimping stent on catheter delivery assembly.
    25. Trollsas, Mikael; Ngo, Michael H.; Anukhin, Boris; Nikanorov, Alexander; Hossainy, Syed; Papp, John E.; Jayasinghe, Dudley; Solter, Zella, Method of crimping stent on catheter delivery assembly.
    26. Rizk, Said, Method of making a polyhydroxyalkanoate filament.
    27. Trollsas, Mikael; Ngo, Michael H.; Anukhin, Boris; Nikanorov, Alexander; Hossainy, Syed; Papp, John E.; Jayasinghe, Dudley; Solter, Zella, Method of making a stent.
    28. Wu, Patrick P., Method of making stents with radiopaque markers.
    29. Wu, Patrick P., Method of making stents with radiopaque markers.
    30. Wu, Patrick P., Method of removing stent islands from a stent.
    31. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
    32. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
    33. Martin, David P.; Rizk, Said, Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning.
    34. Truman, Mari S, Multi-angle orthopedic expansion head fastener.
    35. Gale, David; Huang, Bin; Gueriguian, Vincent; Hossainy, Syed, Optimizing fracture toughness of polymeric stent.
    36. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
    37. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
    38. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
    39. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
    40. Anukhin, Boris; Ngo, Michael H.; Trollsas, Mikael; Hossainy, Syed; Papp, John, Polymer scaffolds having a low crossing profile.
    41. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Process of making polyhydroxyalkanoate medical textiles.
    42. Ganatra, Amit; Shah, Bhavin; Rizk, Said; Martin, David P.; Williams, Simon F., Pultrusion of poly-4-hydroxybutyrate and copolymers thereof.
    43. Pacetti, Stephen; Bei, Joan; Wang, Karen; Liu, Annie, Scaffolds having radiopaque markers.
    44. Wu, Patrick P., Stent with radiopaque markers.
    45. Dugan, Stephen R.; Abbate, Anthony J., Stents with radiopaque markers.
    46. Dugan, Stephen R.; Abbate, Anthony J., Stents with radiopaque markers.
    47. Wu, Patrick P., Stents with radiopaque markers.
    48. Wu, Patrick P., Stents with radiopaque markers.
    49. Bernasconi, Matthew; Connelly, Dennis; Rizk, Said; Martin, David P.; Williams, Simon F., Thermoformed poly-4-hydroxybutyrate medical implants.
    50. Bernasconi, Matthew; Connelly, Dennis; Rizk, Said; Martin, David P.; Williams, Simon F., Thermoformed poly-4-hydroxybutyrate medical implants.
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