Silver-containing compositions, devices and methods for making
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61M-035/00
B05D-001/18
출원번호
US-0441275
(2003-05-19)
발명자
/ 주소
Gibbins, Bruce L.
Hopman, Lance D.
출원인 / 주소
Acrymed
대리인 / 주소
Troutman Sanders LLP
인용정보
피인용 횟수 :
73인용 특허 :
28
초록▼
The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a n
The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any desired shape for its desired uses.
대표청구항▼
1. A method for making a wound dressing for external application to a wound, the wound dressing comprised of hydrophilic polymer fibers and containing silver chloride comprising:adding to the hydrophilic polymer fibers, in no particular order, a first organic solvent solution of a silver cation-dona
1. A method for making a wound dressing for external application to a wound, the wound dressing comprised of hydrophilic polymer fibers and containing silver chloride comprising:adding to the hydrophilic polymer fibers, in no particular order, a first organic solvent solution of a silver cation-donating compound, wherein the first organic solvent is a substantially nonaqueous solvent selected from alcohols, glycols, ketones, ether and ester solvents, and a second organic solvent solution of a chloride anion-donating compound, wherein the second organic solvent is a substantially nonaqueous solvent selected from alcohols, glycols, ketones, ether and ester solvents, and comprising about 5% to 15% of an aqueous solution. 2. The method of claim 1, wherein the hydrophilic polymer fibers comprise carboxymethyl cellulose.3. The method of claim 1, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.4. The method of claim 1, wherein the silver cation-donating compound comprises silver nitrate, silver acetate, silver citrate, or silver sulphate.5. The method of claim 1, wherein the chloride anion-donating compound comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.6. The method of claim 1, wherein the anions of the second organic solvent solution are in an excess of the cations of the first organic solvent solution.7. The method of claim 1, wherein the first organic solvant solution comprises 5% to 15% of an aqueous solution.8. The method of claim 1, wherein the first organic solvent solution is less than 50% aqueous.9. The method of claim 1, wherein the second organic solvent solution is less than 50% aqueous.10. The method of claim 1, wherein the hydrophilic polymer fibers are cross-linked without using an additional cross-linking agent.11. A method for making a wound dressing network comprised of hydrophilic polymer fibers containing silver chloride comprising:adding to the hydrophilic polymer fibers, in no particular order, a first organic solvent solution of a silver canon-donating compound, wherein the first organic solvent is a substantially nonaqueous solvent, and a second organic solvent solution of a chloride anion-donating compound, wherein the second organic solvent is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution. 12. The method of claim 11, wherein the first organic solvent solution comprises 5% to 15% of an aqueous solution.13. The method of claim 11, wherein the first organic solvent solution is less than 50% aqueous.14. The method of claim 11, wherein the hydrophilic polymer fibers comprise carboxymethyl cellulose.15. The method of claim 11, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.16. The method of claim 11, wherein the silver cation-donating compound comprises silver nitrate, silver acetate, silver citrate, or silver sulphate.17. The method of claim 11, wherein the chloride anion-donating compound comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.18. The method of claim 11, wherein the anions of the second organic solvent solution are in an excess of the cations of the first organic solvent solution.19. The method of claim 11, wherein the hydrophilic polymer fibers are cross-linked without using an additional cross-linking agent.20. A hydrophilic antimicrobial fiber comprising,a hydrophilic polymer of a wound dressing for external application to a wound, wherein the hydrophilic polymer of the wound dressing contains a silver salt compound, wherein the silver salt compound is formed by reacting a chloride-containing anionic organic solution that is substantially nonaqueous and comprises about 5% to 15% of an aqueous solution, and a silver-containing cationic organic solution that is substantially nonaqueous. 21. The fiber of claim 20, wherein the silver salt compound is substantially formed on the hydrophilic polymer of the wound dressing.22. The fiber of claim 20, wherein the silver salt compound is substantially formed within the hydrophilic polymer of the wound dressing.23. The fiber of claim 20, wherein the silver salt compound is dispersed throughout the hydrophilic polymer of the wound dressing.24. The fiber of claim 20, wherein the hydrophilic polymer is a cross-linked polymer.25. The fiber of claim 20, wherein the silver salt compound is silver chloride.26. The fiber of claim 20, wherein the hydrophilic polymer comprises carboxymethyl cellulose.27. The fiber of claim 20, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.28. The fiber of claim 20, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate.29. The fiber of claim 20, wherein the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.30. The fiber of claim 20, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.31. The fiber of claim 20, wherein the silver-containing cationic organic solution is less than 50% aqueous.32. The fiber of claim 20, wherein the silver-containing cationic organic solution comprises 5% to 15% of an aqueous solution.33. A hydrophilic antimicrobial wound dressing for external application to a wound comprising:a hydrophilic polymer fiber network containing a concentration of a silver chloride compound, wherein the silver chloride compound is formed by reacting a chloride-containing anionic organic solution that is substantially nonaqeuous and comprises about 5% to 15% of an aqueous solution, and a silver-containing cationic organic solution that is substantially nonaqueous. 34. The wound dressing of claim 33, wherein the silver chloride compound is substantially formed on the hydrophilic polymer fiber network of the wound dressing.35. The wound dressing of claim 33, wherein the silver chloride compound is substantially formed within the hydrophilic polymer fiber network of the wound dressing.36. The wound dressing of claim 33, wherein the silver chloride compound is dispersed throughout the hydrophilic polymer fiber network of the wound dressing.37. The wound dressing of claim 33, wherein the silver-containing cationic organic solution comprises 5% to 15% of an aqueous solution.38. The wound dressing of claim 33, wherein the silver-containing cationic organic solution is less than 50% aqueous.39. The wound dressing of claim 33, wherein the hydrophilic polymer fiber network comprises carboxymethyl cellulose.40. The wound dressing of claim 33, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.41. The wound dressing of claim 33, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate.42. The wound dressing of claim 33, wherein the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.43. The wound dressing of claim 33, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.44. The wound dressing of claim 33, wherein the hydrophilic polymer fiber network is cross-linked without using an additional cross-linking agent.45. A method for applying at least one active antimicrobial agent to a wound dressing for external application to a wound comprising:providing a biocompatible polymeric fiber, wherein the fiber comprises a hydrophilic polymer network and a silver chloride compound, wherein the silver chloride compound is formed by reacting, in no particular order, a chloride-containing anionic first organic solution comprising about 5% to 15% of an aqueous solution, and a silver-containing cationic second organic solution, wherein the first and second organic solutions are selected from alcohols, glycols, ketones, ether or ester solvents. 46. The method of claim 45, wherein the silver chloride compound is substantially formed on the fiber.47. The method of claim 45, wherein the silver chloride compound is substantially formed within the fiber.48. The method of claim 45, wherein the silver chloride compound is dispersed throughout the fiber.49. The method of claim 45, wherein the fiber comprises carboxymethyl cellulose.50. The method of claim 45, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.51. The method of claim 45, wherein the silver-containing cationic second organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate and the chloride-containing anionic first organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.52. The method of claim 45, wherein the anions of the chloride-containing anionic first organic solution are in an excess of the cations of the silver-containing cationic second organic solution.53. The method of claim 45, wherein the chloride-containing anionic first organic solution is substantially nonaqueous and the silver-containing cationic second organic solution is substantially nonaqueous.54. The method of claim 45, wherein [the chloride-containing anionic first organic solution comprises 5% to 15% of an aqueous solution and] the silver-containing cationic second organic solution comprises 5% to 15% of an aqueous solution.55. The method of claim 45, wherein [the chloride-containing anionic first organic solution is less than 50% aqueous and] the silver-containing cationic second organic solution is less than 50% aqueous.56. A wound dressing having antimicrobial properties for external application to a body comprising:at least one strand of a plurality of polymeric fibers comprising: (a) silver as an antimicrobial agent formed by addition of, in no particular order, an organic solvent solution of a silver cation-donating compound and an organic solvent solution of a chloride anion-donating compound, wherein the organic solvent solution of the chloride anion-donating compound is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution; and (b) at least one agent that affects the rate of release of the silver from the polymeric fibers over a period of time when the polymeric fibers are hydrated, wherein the polymeric fibers are hydrophilic, absorbent, and hydratable; and wherein the silver is stabilized against color changes when exposed to light. 57. The wound dressing of claim 56, wherein the polymeric fibers comprise carboxymethyl cellulose.58. The wound dressing of claim 56, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.59. The wound dressing of claim 56, wherein the silver is a silver chloride compound.60. The wound dressing of claim 56, wherein the at least one agent is chloride.61. A method of dressing an external body wound comprising,applying to the wound a least one strand of a plurality of polymeric fibers comprising, (a) silver as an antimicrobial agent formed by addition of, in no particular order, an organic solvent solution of a silver cation-donating compound, and an organic solvent solution of a chloride anion-donating compound, wherein the organic solvent solution of the chloride anion-donating compound is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution; and (b) at least one agent that affects the rate of release of the silver from the polymeric fibers over a period of time when the polymeric fibers are hydrated, wherein the polymeric fibers are hydrophilic, absorbent, and hydratable; and wherein the silver is stabilized against color changes when exposed to light. 62. The method of claim 61, wherein the polymeric fibers comprise carboxymethyl cellulose.63. The method of claim 61, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.64. The method of claim 61, wherein the at least one agent is chloride.65. The method of claim 61, wherein the polymeric fibers are cross-linked without using an additional cross-linking agent.66. A method of forming a wound dressing having antimicrobial properties for external application to a body, the method comprising substantially incorporating on at least one strand of a plurality of polymeric fibers(a) silver as an antimicrobial agent formed by addition of, in no particular order, an organic solvent solution of a silver cation-donating compound, and an organic solvent solution of a chloride anion-donating compound, wherein the organic solvent solution of the chloride anion-donating compound is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution; and (b) at least one agent that affects the rate of release of the silver from the polymeric fibers over a period of time when the polymeric fibers are hydrated, wherein the polymeric fibers are hydrophilic, absorbent and hydratable; and wherein the silver is stabilized against color changes when exposed to light. 67. The method of claim 66, wherein the polymeric fibers comprise carboxymethyl cellulose.68. The method of claim 66, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.69. The method of claim 66, wherein the at least one agent is chloride.70. The method of claim 66, wherein the polymeric fibers are cross-linked without using an additional cross-linking agent.71. A method of forming a wound dressing having antimicrobial properties for external application to a body, the method comprising substantially forming within at least one strand of a plurality of polymeric fibers(a) silver as an antimicrobial agent formed by addition of, in no particular order, an organic solvent solution of a silver cation-donating compound, and an organic solvent: solution of a chloride anion-donating compound wherein the organic solvent solution of the chloride anion-donating compound is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution; and (b) at least one agent that affects the rate of release of the silver from the polymeric fibers over a period of time when the polymeric fibers are hydrated, wherein the polymeric fibers are hydrophilic, absorbent and hydratable, and wherein the silver is stabilized against color changes when exposed to light. 72. The method of claim 71, wherein the polymeric fibers comprise carboxymethyl cellulose.73. The method of claim 71, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.74. The method of claim 71, wherein the at least one agent is chloride.75. The method of claim 71, wherein the polymeric fibers are cross-linked without using an additional cross-linking agent.76. A method offorming a wound dressing having antimicrobial properties for external application to a body, the method comprising dispersing throughout at least one strand of a plurality of polymeric fibers(a) silver as an antimicrobial agent formed by addition of, in no particular order, an organic solvent solution of a silver cation-donating compound, and an organic solvent solution of a chloride anion-donating compound, wherein the organic solvent solution of the chloride anion-donating compound is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution; and (b) at least one agent that affects the rate of release of the silver from the polymeric fibers over a period of time when the polymeric fibers are hydrated, wherein the polymeric fibers are hydrophilic absorbent and hydratable; and wherein the silver is stabilized against color changes when exposed to light. 77. The method of claim 76, wherein the polymeric fibers comprise carboxymethyl cellulose.78. The method of claim 76, wherein the hydrophilic polymer fibers comprise hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.79. The method of claim 76, wherein the at least one agent is chloride.80. The method of claim 76, wherein the polymeric fibers are cross-linked without using an additional cross-linking agent.81. A method of imparting sustained, light stable antimicrobial activity to a polymeric wound dressing for external application to a body comprising:substantially incorporating a silver chloride compound on carboxymethyl cellulose fibers by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a silver chloride compound is substantially formed on the carboxymethyl cellulose fibers. 82. The method of claim 81, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate and the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.83. The method of claim 81, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.84. The method of claim 81, wherein the chloride-containing anionic organic solution is substantially nonaqueous and the silver-containing cationic organic solution is substantially nonaqueous.85. A method of imparting sustained, light stable antimicrobial activity to a polymeric wound dressing for external application to a body comprising:substantially forming a silver chloride compound within carboxymethyl cellulose fibers by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a silver chloride compound is substantially formed within the carboxymethyl cellulose fibers. 86. The method of claim 85, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate and the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.87. The method of claim 85, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.88. The method of claim 85, wherein the chloride-containing anionic organic solution is substantially nonaqueous and the silver-containing cationic organic solution is substantially nonaqueous.89. A method of imparting sustained, light stable antimicrobial activity to a polymeric wound dressing for external application to a body comprising:dispersing a silver chloride compound throughout carboxymethyl cellulose fibers by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a silver chloride compound is dispersed throughout the carboxymethyl cellulose fibers. 90. The method of claim 89, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate and the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.91. The method of claim 89, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.92. The method of claim 89, wherein the chloride-containing anionic organic solution is substantially nonaqueous and the silver-containing cationic organic solution is substantially nonaqueous.93. A method of impregnating a carboxymethyl cellulose fibrous material with a metal salt compound comprising:substantially incorporating on a carboxymethyl cellulose fibrous material a metal salt compound by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a metal salt compound is substantially formed on the carboxymethyl cellulose fibrous material. 94. The method of claim 93, wherein the chloride-containing anionic organic solution and the silver-containing catiomic organic solution are substantially nonaqueous.95. The method of claim 93, wherein the silver-containing cationic organic solution comprises silver nitrate, silver acetate, silver citrate, or silver sulphate and the chloride-containing anionic organic solution comprises sodium chloride, potassium chloride, copper chloride, ferric chloride, zinc chloride, calcium chloride or hydrochloric acid.96. The method of claim 93, wherein the carboxymethyl cellulose fibrous material is shaped into a film, a sheet, a fiber, or a molded article.97. A method of impregnating a carboxymethyl cellulose fibrous material with a metal salt compound comprising:substantially forming within a carboxymethyl cellulose fibrous material a metal salt compound by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a metal salt compound is substantially formed within the carboxymethyl cellulose fibrous material. 98. The method of claim 97, wherein the chloride-containing anionic organic solution and the silver-containing cationic organic solution are substantially nonaqueous.99. The method of claim 97, wherein the carboxymethyl cellulose fibrous material is shaped into a film, a sheet, a fiber, or a molded article.100. A method of impregnating a carboxymethyl cellulose fibrous material with a metal salt compound comprising:dispersing throughout a carboxymethyl cellulose fibrous material a metal salt compound by reacting a chloride-containing anionic organic solution comprising about 5% to 15% of an aqueous solution and a silver-containing cationic organic solution such that a metal salt compound is dispersed throughout the carboxymethyl cellulose fibrous material. 101. The method of claim 100, wherein the chloride-containing anionic organic solution and the silver-containing cationic organic solution are substantially nonaqueous.102. The method of claim 100, wherein the anions of the chloride-containing anionic organic solution are in an excess of the cations of the silver-containing cationic organic solution.103. The method of claim 100, wherein the carboxymethyl cellulose fibrous material is shaped into a film, a sheet, a fiber, or a molded article.104. A method of making a wound dressing comprising:adding to a hydrophilic polymer fiber matrix containing chloride ions, an organic solvent solution of a silver cation-donating compound, wherein the organic solvent is a substantially nonaqueous solvent comprising about 5% to 15% of an aqueous solution, and the chloride ions are in excess of the cations of the silver cation-donating compound in the organic solvent solution, such that a silver salt compound is dispersed throughout the hydrophilic polymer fiber. 105. The method of claim 104, wherein the hydrophilic polymer fiber matrix comprises carboxymethyl cellulose, hydroxymethyl cellulose, cotton, rayon, alginates, calcium alginates, collagen hyaluronic acid, and dextrans.
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