초록

A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.

대표청구항 ▼

1. A biocompatible material comprisinga mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional

1. A biocompatible material comprisinga mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form, the polymer including a degradation control region selected to achieve a desired degradation period, wherein the polymer solution comprises at least one hybrid protein. 2. A biocompatible material comprisinga mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form, the polymer including a degradation control region selected to achieve a desired degradation period, wherein the polymer solution comprises at least one synthetic amino acid sequence. 3. A biocompatible material comprising a mixture of a protein solution and a polymer solution which, upon mixing, cross-link to form a non-liquid, three-dimensional network, and an agent that undergoes color change in response to cross-linking of the mixture.4. A material according to claim 3wherein the agent undergoes color change in response to change in pH. 5. A material according to claim 3wherein the agent exhibits a first color when the mixture is in a liquid state and a second color, different than the first color, when the mixture forms the non-liquid, three-dimensional network. 6. A material according to claim 3wherein the agent exhibits a first color when the mixture is in transition between a liquid state and the non-liquid, three dimensional network, and a second color, different than the first color, when the mixture forms the non-liquid, three-dimensional network. 7. A material according to claim 3wherein the agent includes xylenol blue. 8. A material according to claim 3wherein the agent includes phenol red. 9. A material according to claim 3wherein the agent includes a mixture of xylenol blue and phenol red. 10. A material according to claim 3wherein the agent includes phenolphthalein. 11. A material according to claim 3wherein the agent includes o-cresolphthalein. 12. A material according to claim 3wherein the agent includes bromothymol blue. 13. A material according to claim 3wherein the agent includes a mixture of bromothymol blue and phenolphthalein or o-cresolphthalein. 14. A biocompatible material comprisinga mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link over time to form a non-liquid, three-dimensional network, the polymer including a cross-linking group selected to achieve a desired cross-linking period, wherein the polymer solution comprises at least one hybrid protein. 15. A biocompatible material comprisinga mixture of a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link over time to form a non-liquid, three-dimensional network, the polymer including a cross-lining group selected to achieve a desired cross-linking period, wherein the polymer solution comprises at least one synthetic amino acid sequence.