Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/16
A61C-013/225
출원번호
US-0218632
(2002-08-14)
발명자
/ 주소
Rajaiah, Jayanth
Gilday-Weber, Kimberly Ann
Ernst, Lisa Catron
Owens, Timothy Sadley
Barnes, John E.
Ramji, Nivedita
출원인 / 주소
The Procter &
Gamble Company
인용정보
피인용 횟수 :
28인용 특허 :
78
초록▼
The present invention relates to compositions comprising: (a) from about 15% to about 70% by weight of the composition of a denture adhesive component; (b) a safe and effective amount of a colorant selected from the group consisting of xanthene dyes, fluorescein dyes, free acids and salts thereof, a
The present invention relates to compositions comprising: (a) from about 15% to about 70% by weight of the composition of a denture adhesive component; (b) a safe and effective amount of a colorant selected from the group consisting of xanthene dyes, fluorescein dyes, free acids and salts thereof, and mixtures thereof; and (c) a safe and effective amount of a non-aqueous denture adhesive carrier. The present invention further relates to a method of reducing, inhibiting and/or preventing, calculus, tartar, plaque, stain, and/or microbes in the oral cavity, by applying the above denture adhesive composition to the oral cavity of a denture wearer in need thereof. The present invention further relates to a method of providing improved antimicrobial effects in the oral cavity by applying the above denture adhesive composition to the oral cavity of a denture wearer in need thereof.
대표청구항▼
1. A method of reducing or inhibiting calculus, tartar, plaque, or stain, in an oral cavity, by applying a denture adhesive composition to the oral cavity of a denture wearer in need thereof, the denture adhesive composition comprising:(a) from about 15% to about 70% by weight of the composition of
1. A method of reducing or inhibiting calculus, tartar, plaque, or stain, in an oral cavity, by applying a denture adhesive composition to the oral cavity of a denture wearer in need thereof, the denture adhesive composition comprising:(a) from about 15% to about 70% by weight of the composition of a denture adhesive component; (b) from 0.001% to about 10% by weight of the composition of an antimicorbial colorant selected from the group consisting of Acid Yellow 73, Solvent Red 72, Acid Red 87, Pigment Red 90, Solvent Red 43, Acid Red 98, Acid Red 92, Solvent Red 48, Pigment Red 174, Acid Red 95, Solvent Red 73, Acid Red 51, Food Red 14, Pigment Red 172, Acid Red 94, Solvent Orange 16, Acid Red 52, Basic Violet, 4Acid Violet 9, Acid Red 50, Acid Red 289, Solvent Violet 10, Basic Red 1, Pigment ed 81, Basic Violet 10, Solvent Red 49, Pigment Violet 1, Basic Violet 11, Solvent Green 4, Mordant Red 27, lakes thereof, and mixtures thereof; and (c) a safe and effective amount of a non-aqueous denture adhesive carrier. 2. The method of claim 1 wherein the antimicrobial colorant is selected from the group consisting of Solvent Red 72, Acid Red 87, Pigment Red 90, Solvent Red 43, Acid Red 98, Acid Red 92, Solvent Red 48, Pigment Red 174, Acid Red 95, Solvent Red 73, Acid Red 51, Food Red 14, Pigment Red 172, Acid Red 94, Acid Red 52, Acid Red 50, Acid Red 289, Basic Red 1, Pigment Red 81, Solvent Red 49, lakes thereof, and mixtures thereof.3. The method of claim 2 wherein the antimicrobial colorant is selected from the group consisting of Acid Red 87, Solvent Red 43, Acid Red 92, Solvent Rd 48, Solvent Red 73, Acid Red 51, Food Red 14, and mixtures thereof.4. The method of claim 1 wherein the amount of antimicrobial colorant is from about 0.009% to about 2%, by weight of the composition.5. The method of claim 4 wherein the amount of antimicrobial colorant is from about 0.05% to about 1%, by weight of the composition.6. The method of claim 1 wherein the denture adhesive component is selected from the group consisting of natural gums, synthetic polymeric gums, AVE/MA, salts of AVE/MA, AVE/MA/B, salts of AVE/MA/IB, synthetic polymers, mucoadhesive polymers, water-soluble hydrophilic colloids or polymers having the property of swelling upon exposure to moisture to form a mucilaginous mass, hydroplilic polymers, saccharide derivatives, cellulose derivatives, karaya gum, guar gum, gelatin, algin, sodium alginate, tragacanth, chitosan, polyethylene glycol, acrylamide polymers, polyvinyl alcohol, polyamines, polyquarternary compounds, ethylene oxide polymers, polyvinylpyrrolidone, cationic polyacrylamide polymers, and mixtures thereof.7. The method of claim 6 wherein the denture adhesive component is a salt of AVE/MA, or mixtures thereof, the salt containing a cation selected from the group consisting of Group IA and Group 2A cations of the periodic table, yttrium, titanium, zirconium, vanadium, chromium, manganese, iron, nickel, copper, zinc, boron, aluminum, sodium, and mixtures thereof.8. The method of claim 7 wherein the cation is selected from the group consisting of strontium, zinc, iron, magnesium, calcium, sodium, and mixtures thereof, and wherein the amount of denture adhesive component is from about 20% to about 50%, by weight of the composition.9. The method of claim 8 wherein the composition additionally comprises a cellulose derivative selected from the group consisting of hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and mixtures thereof.10. The method of claim 1 wherein the non-aqueous denture adhesive carrier is selected from the group consisting of a non-aqueous vehicle and a non-adhesive self supporting layer.11. The method of claim 10 wherein the carrier is a non-aqueous vehicle is selected from the group consisting of liquid petrolatum, petrolatum, mineral oil, natural and synthetic oils, fats, natural and synthetic waxes, beeswax, lanolin, shellac, hydrocarbons, hydrocarbon derivatives, vegetable oil waxes, camauba, candelilla, bayberry wax, caprylic/capric triglycerides, corn oil, soybean oil, cottonseed oil, and mixtures thereof, in an amount of from about 20% to about 80%, by weight of the composition.12. The method of claim 10 wherein the carrier is a non-adhesive self-supporting layer wherein the non-adhesive self-supporting layer is selected from the group consisting of polyester, polypropylene, nylon, rayon, cellulose acetate, non-adhesive cellulose derivatives, cloth, fibrous fleece, paper, plastic, leather, synthetic fibers, natural fibers, and mixtures thereof.13. A method of providing an antimicrobial composition in an oral cavity effective for the treatment of plaque, by applying a denture adhesive composition to the oral cavity of a denture wearer in need thereof, the denture adhesive composition comprsing:(a) from about 15% to about 70% by weight of the composition of a denture adhesive component; (b) from 0.001% to about 10% by weight of the composition of an antimicrobial colorant selected from the group consisting of of Acid Yellow 73, Solvent Red 72, Acid Red 87, Pigment Red 90, Solvent Red 43, Acid Red 98, Acid Red 92, Solvent Red4 48, Pigment Red 174, Acid Red 95, Solvent Red 73, Acid Red 51, Food Red 14, Pigment Red 172, Acid Red 94, Solvent Orange 16, Acid Red 52, Basic Violet, Acid Violet 9, Acid Red 50, Acid Red 289, Solvent Violet 10, Basic Red 1, Pigment Red 81, Basic Violet 10, Solvent Red 49, Pigment Violet 1, Basic Violet 11, Solvent Green 4, Mordant Red 27, lakes thereof, and mixtures thereof: and (c) a safe and effective amount of a non-aqueous denture adhesive carrier. 14. The method of claim 13 wherein the antimicrobial colorant is selected from the group consisting of Solvent Red 72, Acid Red 87, Pigment Red 90, Solvent Red 43, Acid Red 98, Acid Red 92, Solvent Red 48, Pigment Red 174, Acid Red 95, Solvent Red 73, Acid Red 51, Food Red 14, Pigment Red 172, Acid Red 94, Acid Red 52, Acid Red 50, Acid Red 289, Basic Red 1, Pigment Red 81, Solvent Red 49, lakes thereof, and mixtures thereof.15. The method of claim 14 wherein the antimicrobial colorant is seleced from the group consisting of Acid Red 87, Solvent Red 43, Acid Red 92, Solvent Red 48, Solvent Red 73, Acid Red 51, Food Red 14, and mixtures thereof.16. The method of claim 13 wherein the amount of antimicrobial colorant is from about 0.009% to about 2%, by weight of the composition.17. The method of claim 16 wherein the amount of antimicrobial colorant from about 0.05% to about 1%, by weight of the composition.18. The method of claim 13 wherein the denture adhesive component is selected from the group consisting of natural gums, synthetic polymeric gums, AVE/MA, salts of AVE/MA, AVE/MA/IB, salts of AVE/MA/IB, synthetic polymers, mucoadhesive polymers, water-soluble hydrophilic colloids or polymers having the property of swelling upon exposure to moisture to form a mucilaginous mass, hydrophillic polymers, saccharide derivatives, cellulose derivatives, karaya gum, guar gum, gelatin, algin, sodium alginate, tragacanth, chitosan, polyethylene glycol, acrylamide polymers, polyvinyl alcohol, polyamines, polyquarternary compounds, ethylene oxide polymers, polyvinylpyrrolidone, cationic polyacrylamide polymers, and mixtures thereof.19. The method of claim 18 wherein the denture adhesive component is a salt of AVE/MA, or mixtures thereof, the salt containing a cation selected from the group consisting of Group IA and Group 2A cations of the periodic table, yttrium, titanium, zirconium, vanadium, chromium, marganese, iron, nickel, copper, zinc, boron, aluminum, sodium, and mixtures thereof.20. The method of claim 19 wherein the cation is selected from the group consisting of strontium, zinc, iron, magnesium, calcium, sodium, and mixtures thereof, and wherein the amount of denture adhesive component is from about 20% to about 50%, by weight of the composition.21. The method of claim 20 wherein the composition additionally comprises a cellulose derivative selected from the group consisting of hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethyl-cellulose sodium carboxymethylcellulose, and mixtures thereof.22. The method of claim 13 wherein the non-aqueous denture adhesive carrier is selected from the group consisting of a non-aqueous vehicle and a non-adhesive self supporting layer.23. The method of claim 22 wherein the carrier is a non-aqueous vehice is selected from the group consisting of liquid petrolacum, petrolatum, mineral oil, natural and synthetic oils, fats, natural and synthetic waxes, beeswax, lanolin, shellac, hydrocarbons hydrocarbon derivatives, vegetable oil waxes, carnauba, candelilla, bayberry wax, caprylic/capric triglycerides, corn oil, soybean oil, cottonseed oil, and mixtures thereof, in an amount of from about 20% to about 80%, by weight of the composition.24. The method of claim 22 wherein the carrier is a non-adhesive self-supporting layer wherein the non-adhesive self-supporting layer is selected from the group consisting of polyester, polypropylene, nylon, rayon, cellulose acetate, non-adhsive cellulose derivatives, cloth, fibrous fleece, paper, plastic, leather, synthetic fibers, natural fibers, and mixtures thereof.
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