Method for producing 2,3-dimethyl-2,3-dinitrobutane and product thereby
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12P-013/00
C07C-205/00
출원번호
US-0235402
(2002-09-04)
발명자
/ 주소
Fitzgerald, Angel A.
Rayms-Keller, Alfredo N.
출원인 / 주소
The United States of America as represented by the Secretary of the Navy
인용정보
피인용 횟수 :
1인용 특허 :
9
초록▼
The present invention includes a method for producing 2,3-dimethyl-2,3-dinitrobutane, particularly in high yields, using a peroxidase enzyme site and reacting propane-2-nitronate at the enzyme under appropriate conditions. Peroxidases such as chloroperoxidase, soybean peroxidase and horseradish pero
The present invention includes a method for producing 2,3-dimethyl-2,3-dinitrobutane, particularly in high yields, using a peroxidase enzyme site and reacting propane-2-nitronate at the enzyme under appropriate conditions. Peroxidases such as chloroperoxidase, soybean peroxidase and horseradish peroxidase are used. High yields include those amounts that increasingly aid in the manufacture of commercial quantities of 2,3-dimethyl-2,3-dinitrobutane.
대표청구항▼
1. A method for producing high yields of 2,3-dimethyl-2,3-dinitrobutane of at least 35%, comprising the steps of:providing a peroxidase enzyme; oxidizing the peroxidase enzyme with a peroxide; and, reacting propane-2-nitronate at such oxidated site at a pH of from about 3.5 to less than 5.0, wherein
1. A method for producing high yields of 2,3-dimethyl-2,3-dinitrobutane of at least 35%, comprising the steps of:providing a peroxidase enzyme; oxidizing the peroxidase enzyme with a peroxide; and, reacting propane-2-nitronate at such oxidated site at a pH of from about 3.5 to less than 5.0, wherein 2,3-dimethyl-2,3-dinitrobutane is produced. 2. The method of claim 1, wherein the peroxidase enzyme is selected from the group consisting of horseradish peroxidase, soybean peroxidase and chloroperoxidase.3. The method of claim 2, wherein the peroxidase enzyme comprises horseradish peroxidase.4. The method of claim 2, wherein the peroxidase enzyme comprises soybean peroxidase.5. The method of claim 2, wherein the peroxidase enzyme comprises chloroperoxidase.6. The method of claim 1, wherein the peroxide is selected from the group consisting of hydrogen peroxide, lithium peroxide, sodium peroxide, calcium peroxide and potassium superoxide.7. The method of claim 6, wherein the peroxide comprises hydrogen peroxide.8. The method of claim 1, wherein the peroxide is added to the reaction in a ratio of from about 25,000 to about 75,000 parts peroxide to about 1 part peroxidase per hour.9. The method of claim 8, wherein the ratio ranges from about 35,000 to about 65,000 parts peroxide to about 1 part peroxidase per hour.10. The method of claim 9, wherein the ratio is present in an amount of about 50,000 parts peroxide to about 1 part peroxidase per hour.11. The method of claim 1, wherein the pH ranges from 3.6 to about 4.8.12. The method of claim 11, wherein the pH ranges from about 3.8 to about 4.5.13. The method of claim 12, wherein the pH ranges from about 3.9 to about 4.3.14. The method of claim 1, wherein the step of reacting propane-2-nitronate at such oxidated site occurs at a temperature of from about 25° C. to about 37° C.15. The method of claim 1, wherein the final yield of 2,3-dimethyl-2,3-dinitrobutane produced ranges from about 50% or greater.16. The method of claim 15, wherein the final yield of 2,3-dimethyl-2,3-dinitrobutane produced ranges from about 65% or greater.17. A method for producing high yields of 2.3-dimethyl-2 3-dinitrobutane of at least 35% comprising the steps of:providing a peroxidase enzyme; oxidizing the peroxidase enzyme with a peroxide; and, reacting propane-2-nitronate at such oxidated site at a pH of from about 3.5 to less than 5.0, wherein 2,3-dimethyl-2,3-dinitrobutane is produced, wherein the final yield of 2,3-dimethyl-2,3-dinitrobutane produced comprises about 70%. 18. A method for producing high yields of 2,3-dimethyl-2,3-dinitrobutane of at least 35% to about 73.6%, comprising the steps of:providing a peroxidase enzyme; oxidizing the peroxidase enzyme with a peroxide; and, reacting propane-2-nitronate at such oxidated site at a pH of from about 3.5 to less than 5.0, wherein 2,3-dimethyl-2,3-dinitrobutane is produced.
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이 특허에 인용된 특허 (9)
Johnson Mark A. (Chillicothe OH) Pokora Alexander R. (Pickerington OH) Cyrus ; Jr. William L. (Ray OH), Biocatalytic oxidation of a reactive primary alcohol using soybean peroxidase.
Johnson Mark A. (Chillicothe OH) Pokora Alexander R. (Pickerington OH) Cyrus ; Jr. William L. (Ray OH), Biocatalytic oxidation using soybean peroxidase.
Johnson Mark A. (Chillicothe OH) Pokora Alexander R. (Pickerington OH) Cyrus ; Jr. William L. (Ray OH), Biocatalytic oxidation using soybean peroxidase.
Pokora Alexander R. (Reynoldsburg OH) Cyrus ; Jr. William L. (Ray OH), Biocatalytic process for preparing phenolic resins using peroxidase or oxidase enzyme.
Wheeler Thurman M. (Columbus OH) Borovsky Joseph (Bexley OH) Pokora Alexander (Pickerington OH), Process for the biocatalytic coupling of aromatic compounds in the presence of a radical transfer agent.
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