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No-modified hemoglobins and uses therefore

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/42
  • C07K-014/805
출원번호 US-0874992 (1997-06-12)
발명자 / 주소
  • Stamler, Jonathan S.
출원인 / 주소
  • Duke University
대리인 / 주소
    Hamilton, Brook, Smith &
인용정보 피인용 횟수 : 1  인용 특허 : 38

초록

S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used which are not specific only for thiol groups, but which nitrosate Hb more extensively, and may produce pol

대표청구항

1. A method for treating a disorder resulting from platelet activation or adherence in an animal or human, comprising administering to the animal of human a composition comprising nitrosylhemoglobin in a therapeutically effective amount, wherein the disorder is selected from the group consisting of:

이 특허에 인용된 특허 (38)

  1. Sehgal Lakshman R. (Flossmoor IL) De Woskin Richard E. (Mount Prospect IL) Moss Gerald S. (Highland Park IL) Gould Steven A. (Highland Park IL) Rosen Arthur L. (Wilmette IL) Sehgal Hansa (Flossmoor I, Acellular red blood cell substitute.
  2. Stahl Quade R. (Springfield VA), Analytical apparatus and method employing purified ozone.
  3. Bruening Wilhelm (Rio de Janeiro BRX) de Andrade Bruening Inai M. R. (Rio de Janeiro BRX) Martinez Concha Francisco J. (Rio de Janeiro BRX), Apparatus for the determination of chemical compounds by chemiluminescence with ozone.
  4. Feola Mario (Lubbock TX) Simoni Jan S. (Lubbock TX) Canizaro ; deceased Peter C. (late of Lubbock TX by Hana Illner ; legal representative), Blood substitute.
  5. Klatz Ronald M. (Chicago IL) Goldman Robert M. (Chicago IL), Brain resuscitation and organ preservation device and method for performing the same.
  6. Stamler Jonathan (220 Marlborough St. ; #1 Boston MA 02116) Loscalzo Joseph (50 Pacella Dr. Dedham MA 02026), Capillary zone electrophoretic detection of biological thiols and their S-nitrosated and oxidized derivatives.
  7. Howard Charles P. (Ann Arbor MI), Chemiluminescent gas analyzer for measuring the oxides of nitrogen.
  8. Howard Charles P. (Ann Arbor MI), Chemiluminescent gas analyzer for measuring the oxides of nitrogen.
  9. Parks, Robert E.; Marietta, Robert L., Chemiluminescent nitrogen detection apparatus and method.
  10. Hsia Jen-Chang (135 Starcrest Irvine CA 92715), Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjuga.
  11. Bucovaz Edsel T. (Memphis TN) Whybrew Walter D. (Memphis TN) Morrison John C. (Brandon MS), Diagnostic test for the detection of cancer.
  12. Etess Edward (La Jolla CA) Budd Allan L. (San Diego CA), Dual channel nitrogen oxides analyzer.
  13. Bonaventura Joseph (Beaufort NC) DeAngelo Joseph (Hamtramck MI) Kilbourn Robert G. (Houston TX), Hemoproteins for inhibition of nitric oxide-mediated hypotension and septic shock.
  14. Lewis Lynette A. (Goshen IN) Yip M. Teresa (Elkhart IN), Lithium salts as red blood cell lysing and hemoglobin denaturing reagents.
  15. Lewis Lynette A. (Goshen IN) Yip M. Teresa (Elkhart IN), Lithium salts as red blood cell lysing and hemoglobin denaturing reagents.
  16. Jonathan S. Stamler ; Joseph Loscalzo ; John D. Folts, Localized use of nitric oxide-adducts to prevent internal tissue damage.
  17. Stamler Jonathan ; Loscalzo Joseph ; Folts John D., Localized use of nitric oxide-adducts to prevent internal tissue damage.
  18. Stamler Jonathan S. ; Loscalzo Joseph ; Folts John D., Localized use of nitric oxide-adducts to prevent internal tissue damage.
  19. Kaesemeyer W. H. (2433 McDowell St. August GA 30904), Method and formulation of stimulating nitric oxide synthesis.
  20. Stamler Jonathan (Chapel Hill NC) Loscalzo Joseph (Dedham MA), Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems.
  21. Hunter Robert L. (Tucker GA), Method for treating vascular obstructions caused by abnormal cells.
  22. Fine David H. (Framingham MA), Method of measuring the N-nitrosoamine content of a sample.
  23. Rounbehler David P. (Concord MA) Reisch John W. (Brookline MA), Molecular sieve trap for nitrogen compound detection.
  24. Fine ; David H. ; Fronduto ; John J. ; Rounbehler ; David P., N-nitroso compound analyzer with sample atomization.
  25. Stamler Johnathan ; Loscalzo Joseph ; Singel David J., Nitrosated and nitrosylated heme proteins.
  26. Stamler, Johnathan; Loscalzo, Joseph, Nitrosated and nitrosylated heme proteins.
  27. Stamler Jonathan (Boston MA) Loscalzo Joseph (Dedham MA), Nitrosation of homocysteine as a method for treating homocysteinemia.
  28. Means Gary E. (Columbus OH) Park Jeen W. (Albany CA), Nitrosothiols as hypotensive agents.
  29. Stamler Jonathan (Boston MA) Loscalzo Joseph (Dedham MA) Simon Daniel (Waban MA) Singel David (Arlington MA), Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality.
  30. Stamler Jonathan ; Loscalzo Joseph ; Simon Daniel ; Singel David, Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality.
  31. Marschall Robert (Sundbyberg SEX) Eketorp Rainer (Danderyd SEX), One-step, one-container method for the preparation of pyridoxylated hemoglobin.
  32. Conboy James J. (Ithaca NY) Hotchkiss Joseph H. (Ithaca NY), Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds.
  33. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
  34. Conboy James J. (Ithaca NY) Hotchkiss Joseph H. (Ithaca NY), Process for HPLC-chemiluminescence detection of non-volatile N-nitroso compounds.
  35. Stamler Jonathan (Chapel Hill NC) Loscalzo Joeseph (Dedham MA) Slivka Adam (Randolph MA) Simon Daniel (Waban MA) Brown Robert (Natick MA) Drazen Jeffrey (Winchester MA), S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof.
  36. Stamler Jonathan (Chapel Hill NC) Loscalzo Joseph (Dover MA) Slivka Adam (Randolph MA) Simon Daniel (Waban MA) Brown Robert (Natick MA) Drazen Jeffrey (Winchester MA), S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof.
  37. Fine David H. (Framingham MA) Lieb David P. (Lexington MA) Rounbehler David P. (Bedford MA), Specific compound detection system with gas chromatograph.
  38. Frostell Claes G. (Vallingby SEX) Hedenstierna Goran (Djursholm SEX) Hogman Marieann E. (Alunda MA SEX) Loscalzo Joseph (Dedham MA) Stamler Jonathan S. (Boston MA), Systemic effects of nitric oxide inhalation.

이 특허를 인용한 특허 (1)

  1. Hsia, Jen-Chang; Ma, Li, Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine.
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