IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0247893
(2002-09-20)
|
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발명자
/ 주소 |
- Manoharan, Muthiah
- Cook, Phillip Dan
- Prakash, Thazha P.
- Mohan, Venkatraman
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| 출원인 / 주소 |
- ISIS Pharmaceuticals, Inc.
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
3 인용 특허 :
72 |
초록
▼
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative pur
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
대표청구항
▼
1. A monomer of the formula: wherein:Y1 is a hydroxyl protecting group; Y2 is a phosphoramidite, H-phosphonate, phosphate triester, or a linking moiety attached to a solid support; each R2, R3, R3′, and R4 is, independently, hydrogen, C(O)R5, substituted or unsubstituted C1-C10 alkyl, substituted or
1. A monomer of the formula: wherein:Y1 is a hydroxyl protecting group; Y2 is a phosphoramidite, H-phosphonate, phosphate triester, or a linking moiety attached to a solid support; each R2, R3, R3′, and R4 is, independently, hydrogen, C(O)R5, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, alkylsulfonyl, or arylsulfonyl, wherein the substituent groups are selected from hydroxyl, amino, alkoxy, carboxy, benzyl, phenyl, nitro, thiol, thioalkoxy, halogen, alkyl, aryl, alkenyl and alkynyl; or R3 and R4, together, are R7; each R5 is, independently, substituted or unsubstituted C1-C10 alkyl, trifluoromethyl, cyanoethyloxy, methoxy, ethoxy, t-butoxy, allyloxy, 9-fluorenylmethoxy, 2-(trimethylsilyl)-ethoxy, 2,2,2-trichloroethoxy, benzyloxy, butyryl; iso-butyryl, phenyl or aryl; R7 is hydrogen or forms a phthalimide moiety with the nitrogen atom to which it is attached; and n is an integer from 1 to about 6. 2. The compound of claim 1 wherein Y1 is dimethoxytrityl.3. The compound of claim 1 wherein Y1 is monomethoxytrityl.4. The compound of claim 1 wherein Y2 is a linking moiety attached to a solid support.5. The compound of claim 1 wherein Y2 is succinyl controlled pore glass (CPG).
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