IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0620245
(2003-07-15)
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§371/§102 date |
19981021
(19981021)
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발명자
/ 주소 |
- Kelly, Craig A.
- Murray, George M.
- Uy, O. Manuel
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출원인 / 주소 |
- The Johns Hopkins University
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인용정보 |
피인용 횟수 :
11 인용 특허 :
4 |
초록
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A polymeric food spoilage sensor comprises a polymer containing a polyazamacrocyclic transition metal complex. The complex selectively binds biogenic amines, such as cadaverine, putrescine and histamine, which are released by food spoilage microorganisms. The polymer undergoes a detectable color cha
A polymeric food spoilage sensor comprises a polymer containing a polyazamacrocyclic transition metal complex. The complex selectively binds biogenic amines, such as cadaverine, putrescine and histamine, which are released by food spoilage microorganisms. The polymer undergoes a detectable color change upon exposure to biogenic amine, thus indicating that food spoilage has probably occurred. In one embodiment, the polymer is molecularly imprinted with the biogenic amine to impart selective binding affinity. The polymer is easily incorporated in common food containers and can be employed in fiber optic detection devices.
대표청구항
▼
1. A method of making a polymer which comprises:copolymerizing a polyazamacrocyclic transition metal complex possessing at least one polymerizable group, monomer and optional crosslinking agent, wherein said polymer undergoes a detectable color change upon exposure to a biogenic amine. 2. The method
1. A method of making a polymer which comprises:copolymerizing a polyazamacrocyclic transition metal complex possessing at least one polymerizable group, monomer and optional crosslinking agent, wherein said polymer undergoes a detectable color change upon exposure to a biogenic amine. 2. The method of claim 1 wherein the polyazamacrocyclic transition metal complex corresponds to the general formula: wherein M is a transition metal ion; n1, n2, n3, n4 can be the same or different and can be 0 or 1; D1, D2, D3, and D4 can be the same or different and can be C, N, O, S, or P; B1a, B1b, B2a, B2b, B3a, B3b, B4a, and B4b can be the same or different and can be H, F, CH3, alcohol, allyl, amine, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy; X1, X2, X3, and X4 can be the same or different and can be N, C, H, or B; A1a, A1b, A2a, A2b, A3a, A3b, A4a, and A4b can be the same or different and can be H, F, NH3, NO2, CO2?, CO2H, CO2R, alcohol, allyl, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy; Y1a, Y1b, Y2a, Y2b, Y3a, Y3b, Y4a, and Y4b may be the same or different, and can be C or O; and, C1a, C1b, C2a, C2b, C3a, C3b, C4a, C4b, C5a, C5b, C6a, C6b, C7a, C7b, C8a, and C8b can be the same or different and can be H, F, NH3, NO2, CO2?, CO2H, CO2R, alcohol, allyl, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy. 3. The method of claim 2 wherein M is nickel(II), D1, D2, D3, and D4 are N, Y1a, Y1b, Y2a, Y2b, Y3a, Y3b, Y4a, and Y4b are C, n1 and n3 are 1, n2 and n4 are 0, X1 and X3 are N, A1a and A3a are styrene, vinyl, amine or carboxyl, and A1a and A3a are electron lone pairs.4. The method of claim 1 wherein the biogenic diamine is selected from the group consisting of cadaverine, putrescine and histamine.5. A method of making a molecularly imprinted polymer which comprises:(A) providing the reaction product of (i) a four-coordinate polyzazamacrocyclic transition metal complex containing two or more polymerizable moieties and (ii) a target molecule comprising biogenic amine, said reaction product possessing a six-coordinate geometry; (B) copolymerizing the reaction product of step (A) with monomer and crosslinking agent to form a polymer; and (C) removing the target molecule from the polymer to provide a molecularly imprinted polymer which selectively binds to the target molecule and undergoes a detectable color change when the target molecule binds thereto. 6. The method of claim 5 wherein the polyazamacrocyclic transition metal complex corresponds to the general formula: wherein M is a transition metal ion;n1, n2, n3, n4 can be the same or different and can be 0 or 1; D1, D2, D3, and D4 can be the same or different and can be C, N, O, S, or P; B1a, B1b, B2a, B2b, B3a, B3b, B4a, and B4b can be the same or different and can be H, F, CH3, alcohol, allyl, amine, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy; X1, X2, X3, and X4 can be the same or different and can be N, C, H, or B; A1a, A1b, A2a, A2b, A3a, A3b, A4a, and A4b can be the same or different and can be H, F, NH3, NO2, CO2?, CO2H, CO2R, alcohol, allyl, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy; Y1a, Y1b, Y2a, Y2b, Y3a, Y3b, Y4a, and Y4b may be the same or different, and can be C or O; and, C1a, C1b, C2a, C2b, C3a, C3b, C4a, C4b, C5a, C5b, C6a, C6b, C7a, C7b, C8a, and C8b can be the same or different and can be H, F, NH3, NO2, CO2?, CO2H, CO2R, alcohol, allyl, styrene, methacrylate, acrylate, vinyl, vinyl ether, vinyl acetate, trialkoxysilane, dialkoxycholorosilane and epoxy. 7. The method of claim 6 wherein M is nickel(II), D1, D2, D3, and D4 are N, Y1a, Y1b, Y2a, Y2b, Y3a, Y3b, Y4a, and Y4b are C, n1 and n3 are 1, n2 and n4 are 0, X1 and X3 are N, A1a and A3a are styrene, vinyl, amine or carboxyl, and A1a and A3a are electron lone pairs.8. The method of claim 5 wherein the biogenic diamine is selected from the group consisting of cadaverine, putrescine and histamine.
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