초록 ▼

A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer

A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

대표청구항 ▼

1. A method of preparing a polymerizable macromer comprising the steps of:incorporating polymerizable groups into hyaluronic acid by reaction of hyaluronic acid with glycidyl acrylate, wherein the reaction between hyaluronic acid and glycidyl acrylate is carried out in formamide. 2. A polymerizable

1. A method of preparing a polymerizable macromer comprising the steps of:incorporating polymerizable groups into hyaluronic acid by reaction of hyaluronic acid with glycidyl acrylate, wherein the reaction between hyaluronic acid and glycidyl acrylate is carried out in formamide. 2. A polymerizable macromer prepared according to the method of claim 1.3. A crosslinkable macromer system comprising one or more polymers providing pendent polymerizable and pendent initiator groups wherein the system is adapted to be polymerized to form a matrix suitable for in vivo application, wherein the system comprises a macromer prepared according to the method of claim 1.4. A macromer system according to claim 3 wherein the polymerizable groups and the initiator group(s) are pendent on the same polymeric backbone.5. A macromer system according to claim 3 wherein the polymerizable groups and initiator group(s) are pendent on different polymeric backbones.6. A macromer system according to claim 3 wherein the pendent initiator groups are bonded to one or more monomers used to prepare the polymeric macromer.7. A macromer system according to claim 3 wherein the pendent initiator groups are bonded to the polymeric macromer itself.8. A macromer system according to claim 3 wherein the pendent initiator groups are selected from the group consisting of long-wave ultra violet (LWUV) light-activatable molecules, visible light-activatable molecules, and thermally activatable molecules.9. A method of forming a polymeric matrix adapted for in vivo application, the method comprising the steps of providing a macromer system according to claim 3, applying the system to a substrate, and cross-linking the system by free radical polymerization to form a matrix.10. A polymeric matrix prepared according to the method of claim 9.11. A method according to claim 9 wherein the polymerizable groups and the initiator group(s) are pendent on the same polymeric backbone.12. A method according to claim 9 wherein the polymerizable groups and initiator group(s) are pendent on different polymeric backbones.13. A method according to claim 9 wherein the pendent initiator groups are bonded to one or more monomers used to prepare the polymeric macromer.14. A method according to claim 9 wherein the pendent initiator groups are bonded to the polymeric macromer itself.15. A method according to claim 9 wherein the pendent initiator groups are selected from the group consisting of long-wave ultra violet (LWUV) light-activatable molecules, visible light-activatable molecules, and thermally activatable molecules.