초록 ▼

A prepolymer is prepared by reacting a mixture containing (a) at least one multifunctional compound, (b) at least one diisocyanate, and (c) at least one diol. The diol has a weight average molecular weight of at most 6000. The prepolymer, when reacted with an excess of water, forms a hydrogel polyme

A prepolymer is prepared by reacting a mixture containing (a) at least one multifunctional compound, (b) at least one diisocyanate, and (c) at least one diol. The diol has a weight average molecular weight of at most 6000. The prepolymer, when reacted with an excess of water, forms a hydrogel polymer. The mixture of the prepolymer and water may be reaction molded, and used to form a contact lens.

대표청구항 ▼

1. A prepolymer, which is an isocyanate terminated prepolymer, is free of unreacted hydroxyl groups and is prepared by reacting a mixture comprising:(a) at least one multifunctional compound containing three or more amine or isocyanate groups, (b) at least one diisocyanate, and (c) at least one diol

1. A prepolymer, which is an isocyanate terminated prepolymer, is free of unreacted hydroxyl groups and is prepared by reacting a mixture comprising:(a) at least one multifunctional compound containing three or more amine or isocyanate groups, (b) at least one diisocyanate, and (c) at least one diol, wherein said diol has a weight average molecular weight of at most 7000, said prepolymer has a viscosity of at most 100,000 cps at 70° C., and said prepolymer, when reacted with an excess of water, forms a hydrogel polymer. 2. The prepolymer of claim 1, wherein component (a) is at least one triisocyanate compound selected from the group consisting of the isocyanurate trimer of hexamethylene diisocyanate, 2,4,6-toluene triisocyanate, p,p′,p″-triphenylmethane triisocyanate, the isocyanurate of isophorone diisocyanate, and the trifunctional biuret of hexamethylene diisocyanate.3. A prepolymer, prepared by reacting a mixture comprising:(a) at least one triisocyanate, (b) at least one diisocyanate, and (c) at least one polyalkylene oxide having two terminal hydroxyl groups, wherein a molar ratio of (a):(b):(c) in said mixture is 0.9-1.1:1.8-3.3:1.8-3.3, said at least one polyalkylene oxide has weight average molecular weight of at most 7000, and said prepolymer, when reacted with an excess water, forms a hydrogel polymer. 4. The prepolymer of claim 3, wherein said molar ratio of (a):(b):(c) in said mixture is 0.97-1.03:1.94-2.06:1.94-2.06, andsaid at least one polyalkylene oxide has a weight average molecular weight of 1000-2000.5. The prepolymer of claim 4, wherein said prepolymer has a viscosity of 1000 to 50,000 cps at 70° C.6. The prepolymer of claim 3, wherein the triisocyanate is the isocyanurate trimer of hexamethylene diisocyanate, 2,4,6-toluene triisocyanate, p,p′,p″-triphenylmethane triisocyanate, the isocyanurate of isophorone diisocyanate, or the trifunctional biuret of hexamethylene diisocyanate.7. The prepolymer of claim 3, wherein the diisocyanate is methylen dicyclohexyl diisocyanate, hexamethylene diisocyanate, isophrone diisocyanate, toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, ethylene diisocyanate, ethylidene diisocyanate, propylene-1,2-diisocyanate, cyclohexylene-1,2-diisocyanate, ethylene diisocyanate, ethylidene diisocyanate, propylene-1,2-diisocyanate, cyclohexylene-1,4-diisocyanate, m-phenylene diisocyanate, 3,3″-diphenyl-4,4″-biphenylene diisocyanate, 4,4″-biphenylene diisocyanate, 4,4″-diphenylmethane diisocyanate, 3,3″-dichloro-4,4″-biphenylene diisocyanate, 1,6-hexamethylene diisocyante, 1,4-tetramethylene diisocyante, 1,10-decamethylene diisocyanate, cumene-2,4-diisocyanate, 1,5-naphthalene diisocyante, 1,4-cyclohexylene diisocyanate, p-tetramethyl xylylene diisocyanate, p-phenylene diisocyante, 4-methoxy-1,3-phenylene diisocyante, 4-chloro-1,3-phenylene diisocyanate, 4-bromo-1,3-phenylene diisocyanate, 4-ethoxy-1,3-phenylene diisocyanate, 2,4-dimethyl-1,3-phenylene diisocyanate, 5,6-dimethyl-1,3-phenylene diisocyanate, 2,4-diisocyanatodiphenylether, 4,4″-diisocyanatodiphenylether, benzidine diisocyanate, 4,6-dimethyl-1,3-phenylene diisocyanate, 9,10-anthracene diisocyanate, 4,4′-diisocyanatodibenzyl, 3,3′-dimethyl-4,4′-diisocyanatodiphenylmethane, 2,6-dimethyl-4,4′-diisocyanatodiphenyl, 2,4-diisocyanatostilbene, 3,3′-dimethoxy-4,4′-diisocyanatodiphenyl, 1,4-anthracenediisocyanate, 2,5-fluorenediisocyanate, 1,8-naphthalene diisocyanate, 2,6-diisocyanatobenzfuran, xylylen diisocyanate, or m-tetramethyl xylylene diisocyanate.8. A prepolymer, which is an isocyanate terminated prepolymer, is free of unreacted hydroxyl groups and is prepared by reacting a mixture comprising:(a) at least one triol, (b) at least one diisocyanate, and (c) at least one polyalkylene oxide having two terminal hydroxyl groups, wherein a molar ratio of (a):(b):(c) in said mixture is 0.9-1.1:4.5-5.5:1.8-2.2, said at least one polyalkylene oxide has a weight average molecular weight of at most 7000, and said prepolymer, when reacted with an excess water, forms a hydrogel polymer. 9. The prepolymer of claim 8, wherein said molar ratio of (a):(b):(c) in said mixture is 0.97-1.03:4.85-5.15:1.94-2.06, and said at least one polyalkylene oxide has a weight average molecular weight of 1000-2000.10. The prepolymer of claim 9, wherein said prepolymer has a viscosity of 1000 to 50,000 cps at 70° C.11. The prepolymer of claim 8, wherein the triol is glycerol, trimethylol propane, or triethanolamine.12. A prepolymer of formula I: wherein X is a trivalent organic group containing 3-20 carbon atoms; Y is a divalent organic group containing 3-20 carbon atoms; Z is an oligomer consisting of monomer units selected from the group consisting of ?(CH2?CH2?O)?, ?(CH2?CH(CH3)?O)?, ?(CH(CH3)?CH2?O)?, ?(CH2?CH(CH2?CH3)?O)?, ?(CH(CH2?CH3)?CH2?O)?, and ?(CH(CH3)?CH(CH3)?O)?, and Z has a weight average molecular weight of at most 7000. 13. The prepolymer of claim 12, whereinY is a divalent aliphatic group, Z has a weight average molecular weight of 1000-2000, and Said prepolymer has a viscosity of 1000 to 50,000 cps at 70° C. 14. The prepolymer of claim 12, wherein the trivalent organic group X contains heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur, and halogens.15. The prepolymer of claim 14, wherein X is a saturated or unsaturated cyclic group or a saturated or unsaturated acyclic alkyl group.16. The prepolymer of claim 15, wherein X is a 6-membered cyclic group containing at least one nitrogen.17. The prepolymer of claim 16, wherein X is a group of formula (V) 18. The prepolymer of claim 12, wherein Y is a group of Formula (VI) or (VII) 19. A prepolymer of formula II: wherein X is trivalent organic group containing 3-20 carbon atoms; Y is divalent organic group containing 3-20 carbon atoms; Z is an oligomer consisting of monomer units selected from the group consisting of ?(CH2?CH2?O)?, ?(CH2?CH(CH3)?O)?, ?(CH(CH3)?CH2?O)?, ?(CH2?CH(CH2?CH3)?O)?, ?(CH(CH2?CH3)?CH2?O)?, and ?(CH(CH3)?CH(CH3)?O)?, and Z has a weight average molecular weight of at most 7000. 20. The prepolymer of claim 1, whereinY is a divalent aliphatic group, Z has a weight average molecular weight of 1000-2000, and Said prepolymer has a viscosity of 1000 to 50,000 cps at 70° C. 21. The prepolymer of claim 19, wherein the trivalent organic group X contains heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur, and halogens.22. The prepolymer of claim 21, wherein X is a saturated or unsaturated cyclic group or a saturated or unsaturated acyclic alkyl group.23. The prepolymer of claim 22, wherein X is a 6-membered cyclic group containing at least one nitrogen.24. The prepolymer of claim 23, wherein X is a group of formula (V) 25. The prepolymer of claim 19, wherein Y is a group of Formula (VI) or (VII)