초록 ▼

Zeaxanthin (ZX) or other medically or commercially important carotenoids can be prepared in microcrystalline form, in an oily carrier liquid, to increase their bioavailability following oral ingestion. Initial processing is carried out to prepare a “rough” or “coarse-grained” carotenoid preparation

Zeaxanthin (ZX) or other medically or commercially important carotenoids can be prepared in microcrystalline form, in an oily carrier liquid, to increase their bioavailability following oral ingestion. Initial processing is carried out to prepare a “rough” or “coarse-grained” carotenoid preparation containing relatively large particles of the ZX or other carotenoid, in a suitable form such as a lyophilized stable powder. The coarse-grain preparation is dissolved in a suitable solvent such as tetrahydrofuran, and mixed with a carrier liquid comprising a digestible oil (such as a vegetable oil) and an emulsifying agent. The resulting oil-and-solvent mixture is injected, along with inert gas such as nitrogen, into a vacuum chamber, where a suitable vacuum and temperature combination is used to remove the solvent in a rapid “flash” manner which does not give the carotenoid crystals time to grow larger through accretion or aggregation. This generates a microcrystalline suspension containing very small particles of the ZX or other cartenoid, in the oily liquid carrier. This product can be further processed if desired, or it can be loaded directly into watertight capsules for oral ingestion. Tests on human volunteers have confirmed that the bioavailability of this microcrystalline form is substantially higher than prior art preparations having larger particles of the carotenoid.

대표청구항 ▼

1. A method of creating a microcrystalline carotenoid preparation for oral ingestion, comprising the following steps:a. mixing a selected carotenoid in a suitable selected non-aqueous solvent, to create a solvent-carotenoid liquid mixture; b. mixing the solvent-carotenoid liquid mixture with an oily

1. A method of creating a microcrystalline carotenoid preparation for oral ingestion, comprising the following steps:a. mixing a selected carotenoid in a suitable selected non-aqueous solvent, to create a solvent-carotenoid liquid mixture; b. mixing the solvent-carotenoid liquid mixture with an oily carrier liquid that is non-toxic and orally ingestible, thereby creating a solvent-carotenoid-carrier liquid mixture; c. passing the solvent-carotenoid-carrier liquid mixture and a stream of inert gas through a spray nozzle causing a mist to emerge, said mist contacting one or more solid surfaces designed for condensate collection, in a manner which (i) causes the mist to form a liquified condensate which can be collected, and (ii) allows the gas and the solvent to be removed from the liquified condensate, wherein the liquified condensate contains the selected carotenoid in a form having average particle sizes less than about 10 microns, in an oily carrier liquid. 2. The method of claim 1 wherein the carotenoid is selected from the group consisting of zeaxanthin, lutein, beta-carotene, lycopene, and astaxanthin.3. The method of claim 1, wherein the solvent is selected from the group consisting of tetrahydrofuran, acetone, ethanol, and ethyl acetate.4. The method of claim 1 wherein water is added to the solvent-carotenoid mixture, and wherein the product which remains after inert gas entrainment and removal is dried by an additional processing step to remove water from the product.5. A carotenoid preparation containing a selected carotenoid in a form having average particle sizes less than about 4 microns in diameter, prepared by the method of claim 1.6. A carotenoid preparation of claim 5, wherein the carotenoid is selected from the group consisting of zeaxanthin, lutein, beta-carotene, lycopene, and astaxanthin.7. A carotenoid preparation containing zeaxanthin in a form having average particle sizes less than about 4 microns in diameter, suspended directly in an edible oily carrier substance.8. The carotenoid preparation of claim 7, wherein the oily carrier substance comprises a vegetable oil.9. The carotenoid preparation of claim 7, wherein the vegetable oil is selected from the group consisting of olive oil, corn oil, canola oil, safflower oil, and palm oil.10. The carotenoid preparation of claim 7, wherein the oily carrier substance comprises a fish oil.