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Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/08
출원번호 US-0430735 (1999-10-29)
발명자 / 주소
  • Ekwuribe, Nnochiri N.
  • Rhadakrishnan, Balasingam
  • Price, Christopher H.
  • Anderson Jr., Wes
  • Ansari, Adam M.
출원인 / 주소
  • Nobex Corporation
대리인 / 주소
    Moore &
인용정보 피인용 횟수 : 5  인용 특허 : 43

초록

The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comp

대표청구항

1. A method for inducing analgesia in a subject, the method comprising delivering across the blood brain barrier of the subject, into the subject's central nervous system, a therapeutically effective amount of an amphiphilic drug-oligomer conjugate having a formula: 2. The method of claim 1 wherein

이 특허에 인용된 특허 (43)

  1. Schiller Peter (Montreal CAX), d 상세보기
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  • Vanlerberghe Guy (Commune de Villevaude FRX) Handjani Rose-Marie (Paris FRX), Aqueous dispersions of lipid spheres and compositions containing the same.
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  • Mill Patrick James (Beaconfield EN) Cresswell Michael Alan (High Wycombe EN) Feinberg Joseph George (London EN), Conjugates of acid polysaccharides and complex organic substances.
  • Ekwuribe Nnochiri Nkem (Cary NC), Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method.
  • Huper Fritz (Wuppertal DT) Rauenbusch Erich (Wuppertal DT) Schmidt-Kastner Gunter (Wuppertal DT) Bomer Bruno (Leverkusen DT) Bartl Herbert (Odenthal-Hahnenberg DT), Crosslinked copolymers of ab 상세보기
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  • Hakimi John ; Kilian Patricia ; Rosen Perry, Polyethylene-protein conjugates.
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  • Appelgren Curt H. (Kungsbacka SEX) Eskilsson Eva C. (Mlnlycke SEX) Uvdal Jonas P. (Gothenburg SEX), Process for preparing rapidly disintegrating granulates.
  • Ahrens Gerhard (Kelkheim DEX), Process for the coating of granules.
  • Plotnikoff, Nicholas P., Process for using endogenous enkephalins and endorphins to stimulate the immune system.
  • Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA), Rate controlled dispenser for administering beneficial agent.
  • Mensi-Fattohi Nahla (151 Rutgers Rd. Piscataway NJ 08854) Molineaux Christopher J. (115 E. 9th St. New York NY 10003) Shorr Robert G. L. (28 Brookfall Rd. Edison NJ 08820), Site specific synthesis of conjugated peptides.
  • Ueno Ryuzo (Nishinomiya JPX) Matsuda Toshio (Itami JPX) Inamine Shigeo (Kobe JPX), Sorbic acid-containing powder or granules.
  • Meisner Lorraine F. (Madison WI) Schinitsky Michael R. (Madison WI), Stabilization of proteins and peptides by chemical binding with chondroitin.
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  • 이 특허를 인용한 특허 (5)

    1. Bentley, Michael D.; Viegas, Tacey X.; Goodin, Richard R.; Cheng, Lin; Zhao, Xuan, Chemically modified small molecules.
    2. Bentley, Michael D.; Viegas, Tacey X.; Goodin, Richard R.; Cheng, Lin; Zhao, Xuan, Chemically modified small molecules.
    3. Bentley, Michael D.; Viegas, Tacey X.; Goodin, Richard R.; Cheng, Lin; Zhao, Xuan, Chemically modified small molecules.
    4. Fishburn, C. Simone; Lechuga-Ballesteros, David; Viegas, Tacey; Kuo, Mei-Chang; Song, Yuan; Gursahani, Hema; Leach, Chester, Chemically modified small molecules.
    5. Livnah,Nurit; Yechezkel,Tamar; Salitra,Yosef; Perlmutter,Boris; Ohne,Onsat; Cohen,Ilana; Litman,Pninit; Senderowitz,Hanoch, Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics.

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