[특허]Breathing gas delivery method and apparatus

RIC Investments, Inc.

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특허 상세정보

MyON담기

내보내기 페이스북 공유 트위터 공유 카카오톡 공유

Breathing gas delivery method and apparatus

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-016/00
미국특허분류(USC)	128/204.18; 128/204.21; 128/204.23
출원번호	US-0378369 (2003-03-03)
발명자 / 주소	Zdrojkowski, Ronald J. Sanders, Mark H. Estes, Mark
출원인 / 주소	RIC Investments, Inc.
인용정보	피인용 횟수 : 116 인용 특허 : 73

초록

An improved methodology and systems for delivery of breathing gas such as for the treatment of obstructive sleep apnea through application of alternating high and low level positive airway pressure within the airway of the patient with the high and low airway pressure being coordinated with the spontaneous respiration of the patient, and improved methods and apparatus for triggering and for leak management in such systems.

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1. A pressure support system comprising:a pressure generating system adapted to generate a flow of breathing gas; a patient circuit having a first end coupled to an outlet of the pressure generating system and a second end; a patient interface device coupled to the second end of the patient circuit; a sensor operatively coupled to the pressure generating system or the patient circuit so as to monitor patient breathing; processing means, operatively coupled to the sensor and the pressure generating system, for (1) causing the pressure generating system to apply the flow of breathing gas to an airway of a patient at an inspiratory positive airway pressure during at least a portion of an inspiratory phase, wherein the inspiratory positive airway pressure is provided at a level relative to an ambient atmospheric pressure that is sufficient to prevent airway obstruction during at least a portion of such a patient's inspiratory breathing cycle, and for (2) adjusting the pressure of the flow of gas in the patient's airway to synchronize the application of positive pressure to such a patient's airway with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration in a manner to maintain the positive pressure in the patient's airway during a sequence of the inspiratory and expiratory phases, with the magnitude of the positive pressure during at least a portion of each expiratory phase being less than the magnitude of the positive pressure during at least a portion of the immediately preceding inspiratory phase. 2. The system as set forth in claim 1, wherein the pressure generating system includes:a flow generator that provides the flow of breathing gas at a selectable pressure level, and a pressure controller operatively coupled to an output of the flow generator so as to control the pressure of the flow of breathing gas delivered to such a patient. 3. The system as set forth in claim 1, wherein the processing means causes the pressure generating system to apply the flow of breathing gas to an airway of such a patient at an inspiratory positive airway pressure that is substantially constant during a majority of an inspiratory phase of such a patient's breathing cycle.4. The system as set forth in claim 1, wherein the processing means identifies changes in such a patient's respiratory state between inspiration and expiration by monitoring patient breathing, determining a patient respiratory gas flow characteristic at selected time intervals to provide a plurality of gas flow characteristics displaced in time from one another based on the monitored breathing, identifying selected pairs of the respiratory gas flow characteristics from the plurality of gas flow characteristics displaced in time from one another, and comparing selected pairs of respiratory gas flow characteristics.5. The system as set forth in claim 4, wherein the processing means determines a predicted value of such a patient's respiratory gas flow based on the monitored breathing, and wherein each selected air of respiratory gas flow characteristics identified by the processing means includes the predicted value of such a patient's respiratory gas flow and such a patient's actual respiratory gas flow rate.6. The system as set forth in claim 1, wherein the processing means identifies changes in such a patient's respiratory state between inspiration and expiration by monitoring the flow of breathing gas to detect instantaneous flow rate, processing the instantaneous flow rate to provide reference indicia, and comparing the instantaneous flow rate and the reference.7. The system as set forth in claim 1, wherein the processing means determines a leak component of the flow of breathing gas by determining a rate of the flow of breathing gas in the patient circuit based on an output of the sensor, integrating the rate of the flow of breathing throughout a plurality of patient respiratory cycles to determine a total respiratory gas volume for the plurality of patient respiratory cycles, and dividing the total respiratory gas volume for the plurality of patient respiratory cycles by a time duration of the plurality of patient respiratory cycles.8. The system as set forth in claim 1, wherein the sensor is a flow sensor adapted to determine a rate of the flow of breathing gas, and further comprising a pressure sensor operatively couple to the patient circuit or the patient interface device, and wherein the processing means calculates, based on the output of the flow sensor and the pressure sensor, a characteristic K of a hypothetical orifice, which represents an orifice through which all leakage of gas from a pressurized system that includes the patient circuit and the patient interface device occurs, and wherein the processing means determines a total instantaneous flow of the leakage of gas from the pressurized system based on the characteristic K of the hypothetical orifice.9. The system as set forth in claim 8, wherein the characteristic K of the hypothetical orifice is calculated over a period of time T as: 10. The system as set forth in claim 1, further comprising a continuously open exhaust port provided in the patient circuit proximate to the patient interface to provide a flow of exhaust gas from within the patient circuit to ambient atmosphere.11. The system as set forth in claim 1, further comprising a continuously open exhaust port provided in the patient interface to provide a flow of exhaust gas from within the patient interface to ambient atmosphere.12. A method of treating obstructive sleep apnea comprising the steps of:providing a pressure support system adapted to generate a flow of breathing gas at a positive pressure greater than ambient atmospheric pressure; communicating the flow of breathing gas to an airway of such a patient via a patient circuit connected to the pressure support system; monitoring patient breathing; applying the flow of breathing gas to an airway of such a patient at an inspiratory positive airway pressure during at least a portion of an inspiratory phase at a pressure sufficient to prevent airway obstruction during at least a portion of such a patient's inspiratory breathing cycle; and adjusting the pressure of the flow of breathing gas in the patient's airway, based on monitoring patient breathing to coordinate the application of positive pressure to such a patient's airway with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration so as to maintain the positive pressure in such a patient's airway during a sequence of inspiratory and expiratory phases, with a magnitude of the positive pressure during at least a portion of each expiratory phase being less than a magnitude of the positive pressure during at least a portion of an immediately preceding inspiratory phase. 13. The method as set forth in claim 12, wherein the positive pressure is applied to an airway of such a patient at an inspiratory positive airway pressure that is substantially constant during a majority of an inspiratory phase of such a patient's breathing cycle.14. The method as set forth in claim 12, further comprising identifying changes in such a patient's respiratory state between inspiration and expiration by monitoring patient breathing, determining a patient respiratory gas flow characteristic at selected time intervals to provide a plurality of gas flow characteristics displaced in time from one another based on the monitored breathing, identifying selected pairs of the respiratory gas flow characteristics from the plurality of gas flow characteristics displaced in time from one another, and comparing selected pairs of respiratory gas flow characteristics.15. The method as set forth in claim 14, further comprising determining a predicted value of such a patient's respiratory gas flow based on the monitored breathing, and wherein each selected pair of respiratory gas flow characteristics includes the predicted value of such a patient's respiratory gas flow and such a patient's actual respiratory gas flow rate.16. The method as set forth in claim 12, further comprising identifying changes in such a patient's respiratory state between inspiration and expiration by monitoring the flow of breathing gas to detect an instantaneous flow rate, processing the instantaneous flow rate to provide reference indicia, and comparing the instantaneous flow rate and the reference.17. The method as set forth in claim 12, further comprising determining a leak component of the flow of breathing gas by determining a rate of the flow of breathing gas, integrating the rate of the flow of breathing for a selected plurality of patient respiratory cycles to determine a total respiratory gas volume for the selected plurality of patient respiratory cycles, and dividing the total respiratory gas volume for the selected plurality of patient respiratory cycles by a time duration associated with the selected plurality of patient respiratory cycles.18. The method as set forth in claim 12, further comprising:measuring a total flow of the flow of breathing gas; measuring a pressure P(t) of the flow of breathing gas; calculating, based on the total flow and the pressure, a characteristic K of a hypothetical orifice which represents an orifice through which all leakage of gas from the pressure support system occurs; and determining a total instantaneous flow of the leakage of gas from the pressure support system based on the characteristic K of the hypothetical orifice. 19. The method as set forth in claim 18, wherein the characteristic K of the hypothetical orifice is calculated over a period of time T as: 20. The method as set forth in claim 12, further comprising exhausting gas from within the patient circuit to ambient atmosphere using a constant diameter exhaust port provided in the patient circuit proximate to the patient interface.21. The method as set forth in claim 12, further comprising exhausting gas from within the patient interface to ambient atmosphere using a constant diameter exhaust port provided in the patient interface.22. A method of treating obstructive sleep apnea comprising the steps of:providing a pressure support system adapted to generate a flow of breathing gas at a positive pressure greater than ambient atmospheric pressure; communicating the flow of breathing gas at the positive pressure to an airway of such a patient; adjusting the pressure of the flow of breathing as to coordinate with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration so as to maintain the positive pressure in such a patient's airway during a sequence of inspiratory and expiratory phases, with a magnitude of the positive pressure during at least a portion of each expiratory phase being less than a magnitude of the positive pressure during at least a portion of an immediately preceding inspiratory phase; maintaining the positive pressure in such a patient's airway during at least a portion of the inspiratory phase at a level sufficient to prevent airway obstruction; and identifying changes in such a patient's respiratory state between inspiration and expiration by monitoring patient breathing, determining a patient respiratory gas flow characteristic at selected time intervals to provide a plurality of gas flow characteristics displaced in time from one another based on the monitored breathing, identifying selected pairs of the respiratory gas flow characteristics from the plurality of gas flow characteristics displaced in time from one another, and comparing selected pairs of respiratory gas flow characteristics. 23. The method as set forth in claim 22, further comprising determining a predicted value of such a patient's respiratory gas flow based on the monitored breathing, and wherein each selected pair of respiratory gas flow characteristics includes the predicted value of such a patient's respiratory gas flow and such a patient's actual respiratory gas flow rate.24. A method of treating obstructive sleep apnea comprising the steps of:providing a pressure support system adapted to generate a flow of breathing gas at a positive pressure greater than ambient atmospheric pressure; communicating the flow of breathing gas at the pressure to an airway of such a patient; adjusting the pressure of the flow of breathing gas to coordinate with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration so as to maintain the positive pressure in such a patient's airway during a sequence of inspiratory and expiratory phases, with a magnitude of the positive pressure during at least a portion of each expiratory phase being less than a magnitude of the positive pressure during at least a portion of an immediately preceding inspiratory phase; maintaining the positive pressure at such a patient's airway during at least a portion of the inspiratory phase at a level sufficient to prevent airway obstruction; and identifying changes in such a patient's respiratory state between inspiration and expiration by monitoring the flow of breathing gas to detect an instantaneous flow rate, processing the instantaneous flow rate to provide reference indicia, and comparing the instantaneous flow rate and the reference. 25. The method as set forth in claim 12, wherein the sequence consists of a single inspiratory phase followed by a single expiratory phase of such a patient's respiration.26. A method of treating obstructive sleep apnea comprising the steps of:providing a pressure support system adapted to generate a flow of breathing gas at a positive pressure greater than ambient atmospheric pressure; communicating the flow of breathing gas at the positive pressure to an airway of such a patient; adjusting the pressure of the flow of breathing as to coordinate with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration so as to maintain the positive pressure in such a patient's airway during a sequence of inspiratory and expiratory phases, with a magnitude of the positive pressure during at least a portion of each expiratory phase being less than a magnitude o the positive pressure during at least a portion of an immediately preceding inspiratory phase; maintaining the positive pressure in such a patient's airway during at least a portion of the inspiratory phase at a level sufficient to prevent airway obstruction; and determining a leak component of the flow of breathing gas by determining a rate of the flow of breathing gas, integrating the rate of the flow of breathing for a selected plurality of patient respiratory cycles to determine a total respiratory gas volume for the selected plurality of patient respiratory cycles, and dividing the total respiratory gas volume for the selected plurality of patient respiratory cycles by a time duration associated with the selected plurality of patient respiratory cycles. 27. A method of treating obstructive sleep apnea comprising the steps of:providing a pressure support system adapted to generate a flow of breathing gas at a positive pressure greater than ambient atmospheric pressure; communicating the flow of breathing gas at the positive pressure to an airway of a patient; adjusting the pressure of the flow of breathing gas to coordinate with an occurrence of alternating inspiratory and expiratory phases of such a patient's respiration so as to maintain the positive pressure in such a patient's airway during a sequence of inspiratory and expiratory phases, with a magnitude of the positive pressure during at least a portion of each expiratory phase being less than a magnitude of the positive pressure during at least a portion of an immediately preceding inspiratory phase; maintaining the positive pressure in such a patient's airway during at least a portion of the inspiratory phase at a level sufficient to prevent airway obstruction; measuring a total flow of the flow of breathing gas; measuring a pressure P(t) of the flow of breathing gas; calculating, based on the total flow and the pressure, a characteristic K of a hypothetical orifice, which represents an orifice through which all leakage of gas from the pressure support system occurs; and determining a total instantaneous flow of the leakage of gas from the pressure support system based on the characteristic K of the hypothetical orifice. 28. The method as set forth in claim 27, wherein the characteristic K of the hypothetical orifice is calculated over a period of time T as:

이 특허에 인용된 특허 (73)

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Breathing gas delivery method and apparatus

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Breathing gas delivery method and apparatus

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