Nutraceuticals or nutritional supplements and method of making
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23G-003/30
A61K-009/68
출원번호
US-0621780
(2000-07-21)
발명자
/ 주소
McGrew, Gordon N.
Barkalow, David G.
Johnson, Sonya S.
Record, David W.
Patel, Mansukh M.
Nimz, Jack D.
Zibell, Steven E.
Yatka, Robert J.
Greenberg, Michael J.
Aumann, Rebecca A.
Zyck, Dan
출원인 / 주소
Wm. Wrigley Jr. Company
대리인 / 주소
Brinks Hofer Gilson &
인용정보
피인용 횟수 :
35인용 특허 :
163
초록▼
A method for producing a chewing gum with a controlled release active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the active agent, such as a nutraceutical or nutritional supplement, by coating and drying. The active agent is coated by
A method for producing a chewing gum with a controlled release active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the active agent, such as a nutraceutical or nutritional supplement, by coating and drying. The active agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated active agent is preferably then co-dried and particle sized to produce a release-modified active agent for use in chewing gum. The active agent may also be used in a coating on a chewing gum product, as part of a rolling compound applied to the chewing gum product, or as a part of the liquid in a liquid-center chewing gum product.
대표청구항▼
1. A method of producing a chewing gum product containing a physically-modified active agent in order to control the release rate of the active agent comprising the steps of:a) mixing a quantity of an active agent, which comprises one or more materials selected from the group consisting of benzoin ,
1. A method of producing a chewing gum product containing a physically-modified active agent in order to control the release rate of the active agent comprising the steps of:a) mixing a quantity of an active agent, which comprises one or more materials selected from the group consisting of benzoin , glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lecithin, lycopene, polyphenol, psyllium, chromium picolinate and phenylpropanolamine, with a modifying agent and a high-potency sweetener selected from the group consisting of neotame, aspartame, alitame, salts of acesulfame, cyclamate and its salts, saccharin and its salts, thaumatin, monellin, dihydrochalcones, sucralose and combinations thereof, to form a modified release rate active agent and high-potency sweetener combination; b) adding a quantity of the combination to a chewing gum formulation to provide an effective amount of the active agent in the chewing gum formulation. 2. The method of claim 1 wherein said modifying agent is an encapsulating agent.3. The method of claim 2 wherein the active agent and encapsulating agent are also mixed with a solvent and the resulting mixture is spray dried prior to being added to the chewing gum.4. The method of claim 3 wherein the encapsulating agent is selected from the group consisting of maltodextrin and gum arabic.5. The method of claim 2 wherein the active agent is fluid-bed coated with a solution of encapsulating agent and solvent in order to increase the rate of release of the active agent in the chewing gum.6. The method of claim 2 wherein the active agent is encapsulated by coacervation in order to decrease the rate of release of active agent in chewing gum.7. The method of claim 2 wherein the active agent is mixed with a molten encapsulating agent and the active agent is encapsulated by spray chilling in order to decrease the rate of release of the active agent in the chewing gum.8. The method of claim 2 wherein the active agent is mixed with a polymer as the encapsulating agent and the resulting mixture is extruded into fibers in such a way as to encapsulate the active agent in order to decrease the rate of release of the active agent in the chewing gum.9. The method of claim 8 wherein the polymer is selected from the group consisting of PVAC, hydroxypropyl cellulose, polyethylene and plastic polymers.10. The method of claim 1 wherein the active agent is mixed with an absorbent as the modifying agent.11. The method of claim 1 wherein another active agent is added to the chewing gum formulation.12. The method of claim 11 wherein the other active agent has been treated to modify its release rate from the chewing gum.13. A chewing gum product made according to the method of claim 1.14. The method of claim 1 wherein the effective amount of active agent in the chewing gum formulation is from about 0.2% to about 5% in the chewing gum product.15. A method of producing a chewing gum containing a physically-modified active agent in order to control the release rate of the active agent comprising the steps of:a) mixing a quantity of the active agent, which comprises one or more materials selected from the group consisting of benzoin, glucosamine, prapeseed extract, quarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lecithin, lycopene, polyphenol, psyllium, chromium picolinate and phenylpropanolamine, with a high-potency sweetener selected from the group consisting of neotame, aspartame, alitame, salts of acesulfame, cyclamate and its salts, saccharin and its salts, thaumatin, monellin, dihydrochalcones, sucralose and combinations thereof, and an agglomerating agent and solvent to partially coat the active agent, agglomerating agent and high-potency sweetener; b) removing the solvent from the mixture of active agent, high-potency sweetener and agglomerating agent to form a dried material; and c) adding a quantity of the dried material to a chewing gum formulation to provide an effective amount of the active agent in the gum. 16. The method of claim 1 wherein the dried material is ground to a powder prior to adding the dried material to the chewing gum.17. A chewing gum product made according to the method of claim 15.18. The method of claim 15 wherein the effective amount of active agent in the chewing gum formulation is from about 0.2% to about 5% in the chewing gum product.19. A method of producing a chewing gum product containing an active agent, which comprises one or more materials selected from the group consisting of benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lycopene, polyphenol, psyllium, chromium picolinate and phenylpropanolamine, wherein the active agent is a part of a rolling compound applied on the chewing gum product.20. A chewing gum product made according to the method of claim 19.21. A method of producing a chewing gum product containing an active agent, which comprises one or more materials selected from the group consisting of benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lycopene, polyphenol, psyllium, chromium picolinate and phenylpropanolamine, wherein the active agent is part of the liquid in a liquid-center chewing gum product.22. A chewing gum product made according to the method of claim 21.23. A method of producing a chewing gum product containing an absorption-enhanced active agent in order to control the absorption rate of the active agent comprising the steps of:a) mixing a quantity of the active agent, which comprises one or more materials selected from the group consisting of nutraceuticals and nutritional supplements, with an absorption enhancing agent selected from the group consisting of ethanol, polytheylene glycol, 2-pyrrolidones, myristic acid, p-phenyl phenol, nitrobenzene, stearyl alcohol, cetyl alcohol, croton oil, liquid paraffin, dimethyl sulfoxide, non-ionic surfactants, liposomes, lecithin fractions, long chain amphipathic molecules and mixtures thereof; and b) incorporating a quantity of the mixture into a chewing gum formulation to provide an active agent level in the chewing gum formulation of from about 12 micrograms to about 250 milligrams per gram of chewing gum product. 24. A chewing gum product made according to the method of claim 23.25. A coated chewing gum product containing an active agent comprising a compound selected from the group consisting of capsicum, chamomile, cat's claw, echinacea, garlic, ginger, green tea, golden seal, kava kava, nettle, passion flower, saw palmetto, St. John's wort, valerian, benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lycopene, polyphenol, psyllium, chromium picolinate, phenylpropanolamine and mixtures thereof, wherein the active agent is a part of a coating on a chewing gum pellet.26. A method of producing coated chewing gum products containing at least one active agent in the coating, the active agent comprising a compound selected from the group consisting of capsicum, chamomile, cat's claw, echinacea, garlic, ginger, green tea, golden seal, kava kava, nettle, passion flower, saw palmetto, St. John's wort, valerian, benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lycopene, polyphenol, psyllium, chromium picolinate, phenylpropanolamine and mixtures thereof, comprising the steps of:a) providing chewing gum product cores: b) providing a coating solution; c) coating the chewing gum product cores with the coating solution to provide coated chewing gum products, the coating including the active agent at a level of from about 12 micrograms to about 250 milligrams per gram of coated chewing gum product. 27. The method of claim 26 wherein the active agent is mixed in the coating solution prior to coating the cores.28. The method of claim 27 wherein the active agent is also mixed with a solvent before adding to the coating solution and the resulting mixture is added to the chewing gum coating.29. The method of claim 28 wherein the solvent is water, alcohol or flavor.30. The method in claim 26 wherein a high-potency sweetener selected from the group consisting of aspartame, alitame, salts of acesulfame, cyclamate and its salts, saccharine and its salts, neotame, thaumatin, monellin, dihydrochalcones, sucralose and combinations thereof is mixed in the coating solution.31. The method of claim 26 wherein the coating operation includes the application of multiple coats of coating solution and application of powder material between coats of coating solution.32. The method of claim 31 wherein the active agent is included in the powder material.33. The method of claim 31 wherein an active agent is included in both the coating solution and the powder material.34. The method of claim 26 wherein an active agent is also included in the chewing gum cores.35. The method of claim 34 wherein the active agents in the gum cores and coating are the same.36. The method of claim 34 wherein the active agent in the cores is different than the active agent in the coating.37. The method of claim 34 wherein at least one of the active agents in the coating and in the cores is treated with a modifying agent to control the release of the active agent prior to being incorporated into the coating or into the cores.38. The method of claim 26 wherein at least two different coating solutions are used to make the coating.39. The method of claim 38 wherein the active agent is mixed with the first of the at least two different coating solutions and applied to the cores with the first coating solution to form a film, and a second coating solution without an active agent is applied over the film coated cores.40. The method of claim 26 wherein the active agent in the coating has been treated with a modifying agent to control its release prior to being used in the coating.41. A method of producing coated chewing gum products containing at least one active agent in the coating the active agent comprising a compound selected from the group consisting of capsicum, chamomile, cat's claw, echinacea, garlic, ginger, green tea, golden seal, kava kava, nettle, passion flower, saw palmetto, St. John's wort, valerian, benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lycopene, polyphenol, psyllium, chromium picolinate, phenylpropanolamine and mixtures thereof, comprising the steps of:a) providing chewing gum product cores: b) providing a coating solution; c) coating the chewing gum product cores with the coating solution to provide coated chewing gum products, the coating including the active agent at a level of from about 0.2% to about 5% in the gum products. 42. A method of producing coated chewing gum products containing at least one active agent in the coating treated so as to modify the absorption of the active agent in the mouth, the active agent comprising a compound selected from the group consisting of capsicum, chamomile, cat's claw, echinacea, garlic, ginger, ginko, ginseng, green tea, golden seal, kava kava, nettle, passion flower, saw palmetto, St. John's wort, valerian, benzoin, glucosamine, grapeseed extract, guarana, phosphotidylserine, phytosterols, phytochemicals, isoflavones, lecithin, lycopene, polyphenol, psyllium, chromium picolinate, phenylpropanolamine and mixtures thereof, comprising the steps of:a) providing chewing gum product cores: b) providing a coating solution; c) coating the chewing gum product cores with the coating solution to provide coated chewing gum products, the coating including the active agent at a level of from about 12 micrograms to about 250 milligrams per gram of coated chewing gum product and an absorption enhancing agent selected from the group consisting of ethanol, polytheylene glycol, 2-pyrrolidones, myristic acid, p-phenyl phenol, nitrobenzene, stearyl alcohol, cetyl alcohol, croton oil, liquid paraffin, dimethyl sulfoxide, non-ionic surfactants, liposomes, lecithin fractions, and long chain amphipathic molecules and mixtures thereof.
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