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Modified oligonucleotides for mismatch discrimination 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
  • C12Q-001/68
  • C07H-021/02
출원번호 US-0724959 (2000-11-28)
발명자 / 주소
  • Dempcy, Robert O.
  • Afonina, Irina A.
  • Singer, Michael J.
  • Kutyavin, Igor V.
출원인 / 주소
  • Epoch Pharmaceuticals, Inc.
대리인 / 주소
    Townsend and Townsend and Crew LP
인용정보 피인용 횟수 : 26  인용 특허 : 32

초록

Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

대표청구항 ▼

1. A method for primer extension, the method comprising incubating a polynucleotide containing a target sequence with one or more oligonucleotide primers complementary to the target sequence, in the presence of a polymerizing enzyme and nucleotide substrates under conditions favorable for polymeriza

이 특허에 인용된 특허 (32)

  1. Eugeny Alexander Lukhtanov ; Mikhail A. Podyminogin ; Joel Hedgpeth, Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids.
    상세보기
  2. Kutyavin Igor V. ; Lukhtanov Eugeny A. ; Gamper Howard B. ; Meyer ; Jr. Rich B., Covalently linked oligonucleotide minor grove binder conjugates.
    상세보기
  3. Petrie Charles R. ; Meyer Rich B. ; Tabone John C. ; Hurst Gerald D., Cross-linking oligonucleotides.
    상세보기
  4. Meyer ; Jr. Rich B. ; Gamper Howard B. ; Kutyavin Igor V. ; Gall Alexander A. ; Petrie Charles R. ; Tabone John C. ; Hurst Gerald D., Crosslinking oligonucleotides.
    상세보기
  5. Froehler Brian (Belmont CA) Wagner Rick (Belmont CA) Matteucci Mark (Burlingame CA) Jones Robert J. (Millbrae CA) Gutierrez Arnold J. (Sandy Lane CA) Pudlo Jeff (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines.
    상세보기
  6. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
    상세보기
  7. Gelfand David H. (Oakland CA) Holland Pamela M. (Oakland CA) Saiki Randall K. (Richmond CA) Watson Robert M. (Berkeley CA), Homogeneous assay system using the nuclease activity of a nucleic acid polymerase.
    상세보기
  8. Hedgpeth Joel ; Afonina Irina A. ; Kutyavin Igor V. ; Lukhtanov Eugeny A. ; Belousov Evgeniy S. ; Meyer ; Jr. Rich B., Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders.
    상세보기
  9. Arnold ; Jr. Lyle J. (San Diego CA) Reynolds Mark A. (San Diego CA) Bhatt Ram S. (San Diego CA), Linking reagents for nucleotide probes.
    상세보기
  10. Drmanac Radoje T. (Beograd YUX) Crkvenjakov Radomir B. (Beograd YUX), Method of determining an ordered sequence of subfragments of a nucleic acid fragment by hybridization of oligonucleotide.
    상세보기
  11. Drmanac Radoje T. (Belgrade YUX) Crkvenjakov Radomir B. (Belgrade YUX), Method of sequencing by hybridization of oligonucleotide probes.
    상세보기
  12. Beattie Kenneth L., Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions.
    상세보기
  13. Ward David C. (Guilford CT) Langer Pennina R. (Monsey NY) Waldrop ; III Alexander A. (Charlottesville VA), Modified polynucleotides and methods of preparing same.
    상세보기
  14. Nelson Paul S. ; Kent Mark A., Non-nucleoside 1,3-diol reagents and their use to label or modify synthetic oligonucleotides.
    상세보기
  15. Arnold ; Jr. Lyle J. (San Diego CA) Reynolds Mark A. (San Diego CA) Bhatt Ram S. (San Diego CA), Non-nucleotide linking reagents for nucleotide probes.
    상세보기
  16. Khanna Pyare (Mountain View CA) Ullman Edwin F. (Atherton CA), Novel alkyl substituted fluorescent compounds and polyamino acid conjugates.
    상세보기
  17. Urdea Michael S. (Alamo CA) Warner Brian (Martinez CA) Horn Thomas (Berkeley CA), Nucleic acid multimers and amplified nucleic acid hybridization assays using same.
    상세보기
  18. Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기
  • Froehler Brian (Belmont CA) Jones Robert J. (Daly City CA), Oligonucleotides containing 5-propynyl pyrimidines.
    상세보기
  • Meyer ; Jr. Rich B. ; Afonina Irina A. ; Kutyavin Igor V., Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination.
    상세보기
  • Rich B. Meyer, Jr. ; Irina A. Afonina ; Igor V. Kutyavin, Oligonucleotides containing pyrazolo[3,4-d]pyrimidines for hybridization and mismatch discrimination.
    상세보기
  • Mitsuhashi Masato (Irvine CA) Cooper Allan J. (Bellvue WA) Waterman Michael S. (Culver City CA) Pevzner Pavel A. (State College PA), Oligoprobe designstation: a computerized method for designing optimal DNA probes.
    상세보기
  • Caskey C. Thomas ; Shumaker John ; Metspalu Andres,EEX, Parallel primer extension approach to nucleic acid sequence analysis.
    상세보기
  • Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
    상세보기
  • Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
    상세보기
  • Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
    상세보기
  • Reed Michael W. (Seattle WA) Meyer ; Jr. Rich B. (Woodinville WA) Petrie Charles R. (Woodinville WA) Tabone John C. (Bothell WA), Solid support for synthesis of 3′-tailed oligonucleotides.
    상세보기
  • Mullah Khairuzzaman Bashar ; Andrus William A., Solid support reagents for the direct synthesis of 3'-labeled polynucleotides.
    상세보기
  • Urdea Mickey (Alamo CA) Warner Brian (Redwood City CA), Solution phase nucleic acid sandwich assay.
    상세보기
  • Falkow Stanley (Seattle WA) Moseley Stephen L. (Kirkland WA), Specific DNA probes in diagnostic microbiology.
    상세보기
  • Lockhart David J. (Santa Clara CA) Vetter Dirk (Freiburg DEX) Diggelmann Martin (Niederdorf CHX), Surface-bound, unimolecular, double-stranded DNA.
    상세보기
  • Reed Michael W. (3575 NE. 180th Seattle WA 98105) Meyer ; Jr. Rich B. (15411 NE. 176th Pl. Woodinville WA 98072), Trifunctional intermediates for preparing 3′-tailed oligonucleotides.
    상세보기

    • 이 특허를 인용한 특허 (26)

    1. Geary, Richard S.; Yu, Zhengrong; Wedel, Mark K.; Tribble, Diane, Administering antisense oligonucleotides complementary to human apolipoprotein B.
      상세보기
    2. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
      상세보기
    3. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
      상세보기
    4. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
      상세보기
    5. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of apolipoprotein B expression.
      상세보기
    6. Crooke,Roseanne M.; Graham,Mark; Freier,Susan M., Antisense modulation of apolipoprotein B expression.
      상세보기
    7. Crooke, Rosanne M.; Graham, Mark J.; Freier, Susan M., Antisense modulation of apolipoprotein B-expression.
      상세보기
    8. Crooke, Rosanne M.; Graham, Mark J.; Freier, Susan M., Antisense modulation of apolipoprotein B-expression.
      상세보기
    9. Sacks, Frank M.; Tribble, Diane, Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III.
      상세보기
    10. Hogan, James J.; Andruszkiewicz, Irene; Bungo, Jennifer J.; Kaplan, Shannon K., Compositions and methods to detect Candida albicans nucleic acid.
      상세보기
    11. Hogan, James J.; Andruszkiewicz, Irene; Bungo, Jennifer J.; Kaplan, Shannon K., Compositions and methods to detect nucleic acid.
      상세보기
    12. Hogan, James J.; Andruszkiewicz, Irene; Bungo, Jennifer J.; Kaplan, Shannon K., Compositions and methods to detect nucleic acid.
      상세보기
    13. Pollner, Reinhold B.; Livezey, Kristin W., Compositions and methods to detect nucleic acid.
      상세보기
    14. Hogan, James J.; Andruszkiewicz, Irene; Bungo, Jennifer J.; Kaplan, Shannon K., Compositions to detect Candida albicans nucleic acid.
      상세보기
    15. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression ApoB.
      상세보기
    16. Afonina, Irina A.; Belousov, Yevgeniy S.; Mahoney, Walt, Detection of methicillin-resistant Staphylococcus aureus .
      상세보기
    17. Afonina, Irina A.; Belousov, Yevgeniy S.; Mahoney, Walt, Detection of methicillin-resistant Staphylococcus aureus .
      상세보기
    18. Joo, Sunghae A.; Dockter, Janel M., Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals.
      상세보기
    19. Afonina, Irina A.; Belousov, Yevgeniy S., Methods and compositions for detecting antibiotic resistant bacteria.
      상세보기
    20. Vorobiev, Alexei; Lukhtanov, Eugeny A., Minor groove binder phosphoramidites and methods of use.
      상세보기
    21. Mullah, Khairuzzaman Bashar; Ma, Zhaochun; Bi, Wanli, Modified oligonucleotides and applications thereof.
      상세보기
    22. Seela,Frank; Bergmann,Frank; Von Der Eltz,Herbert; Heindl,Dieter; Seidel,Christoph; Becher,Georg, Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses.
      상세보기
    23. Yager, Paul; Lutz, Barry R.; Fu, Elain S.; Fridley, Gina; Le, Huy Quang; Kauffman, Peter C., Reagent patterning in capillarity-based analyzers and associated systems and methods.
      상세보기
    24. Crooke, Rosanne M.; Graham, Mark J.; Mah, Steven, SNPs of apolipoprotein B and modulation of their expression.
      상세보기
    25. West, Jason Andrew Appleton; Satterfield, Brent Coleman, Selection of aptamers based on geometry.
      상세보기
    26. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Short antisense compounds with gapmer configuration.
      상세보기

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