IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0806415
(2004-03-23)
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발명자
/ 주소 |
- Senanayake, Chrisantha Hugh
- Fang, Qun Kevin
- Han, Zhengxu
- Krishnamurthy, Dhileepkumar
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
34 |
초록
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Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic o
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic or optically pure sibutramine metabolite, and optionally an additional pharmacologically active compound.
대표청구항
▼
1. A method of treating or preventing pain which comprises administering to a patient in need of such treatment and prevention a therapeutically or prophylactically effective amount of a racemic or optically pure sibutramine metabolite, or a pharmaceutically acceptable salt, solvate, or clathrate th
1. A method of treating or preventing pain which comprises administering to a patient in need of such treatment and prevention a therapeutically or prophylactically effective amount of a racemic or optically pure sibutramine metabolite, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, wherein the pain is thoratic outlet obstruction syndrome.2. A method of treating or preventing pain which comprises administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of a racemic or optically pure sibutramine metabolite, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, wherein the pain is a compression and entrapment neuropathy.3. The method of claim 2, wherein the compression and entrapment neuropathy is ulnar nerve palsey, carpal tunnel syndrome, peroneal nerve palsey, or radial nerve palsey.4. A method of treating or preventing pain which comprises administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of a racemic or optically pure sibutramine metabolite, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, wherein the pain is Guillain-Barr? syndrome.5. A method of treating or preventing pain which comprises administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of a racemic or optically pure sibutramine metabolite, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, wherein the pain is associated with or results from: trauma caused by injury or surgical operation; tumors; bony hyperostosis; casts; crutches; prolonged cramped postures; hemorrhage into a nerve; exposure to cold or radiation; a collagen-vascular disorder; a metabolic disease or disorder; an infectious disease; a toxin; autoimmune reactions; or nutritional deficiency.6. The method of claim 5, wherein the metabolic disease or disorder is hypothyroidism, porphyria, sarcoidosis, amyloidosis, uremia, or diabetes.7. The method of claim 5, wherein the infectious disease is Lyme disease or HIV.8. The method of claim 5, wherein the toxin is emetine, hexobarbital, barbital, chlorobutanol, sulfonamides, phenytoin, nitrofurantoin, the vinca alkaloids, heavy metals, carbon monoxide, triorthocresylphosphate, or orthodinitrophenol.9. The method of claim 5, wherein the nutritional deficiency is vitamin B deficiency.10. The method of claim 1, 2, 4 or 5, wherein the sibutramine metabolite is (R/S)-desmethylsibutramine, (R)-desmethylsibutramine, (S)-desmethylsibutramine, (R/S)-didesmethylsibutramine, (R)-didesmethylsibutramine, or (S)-didesmethylsibutramine.11. The method of claim 10, wherein the sibutramine metabolite is (R)-didesmethylsibutramine.12. The method of claim 10, wherein the sibutramine metabolite is (S)-didesmethylsibutramine.
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