Compounds and methods for the treatment of urogenital disorders
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/21
A61K-031/195
A61K-031/185
A61K-031/155
A61K-031/535
출원번호
US-0094409
(2002-03-06)
발명자
/ 주소
Mak,Vivien H. W.
Grayson,Stephen
출원인 / 주소
Cellegy Pharmaceuticals, Inc.
대리인 / 주소
Townsend and Townsend and Crew LLP
인용정보
피인용 횟수 :
24인용 특허 :
20
초록▼
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of the urinary tract) and sexual dysf
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of the urinary tract) and sexual dysfunctions, such as, for example, female sexual arousal disorders and female sexual orgasmic disorders, using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, α-adrenergic receptor antagonists, β-adrenergic receptor agonists, phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e. g., cAMP mimetics), superoxide scavengers, potassium channel activators, estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates and cGMP-dependent protein kinase activators (e.g., cGMP mimetics).
대표청구항▼
What is claimed is: 1. A method for relieving the vulvar pain of vulvodynia in a patient, the method comprising topically administering to the affected vulvar area of the patient a NO donor in a therapeutically effective amount, wherein the vulvar pain which is not caused by dyspaerunia is relieved
What is claimed is: 1. A method for relieving the vulvar pain of vulvodynia in a patient, the method comprising topically administering to the affected vulvar area of the patient a NO donor in a therapeutically effective amount, wherein the vulvar pain which is not caused by dyspaerunia is relieved. 2. The method of claim 1, wherein the NO donor is nitroglycerin. 3. The method of claim 1, wherein said NO donor is in a form selected from the group consisting of gel, ointment, cream, lotion, powder, solution, suspension, spray, paste, oil, suppository, and foam. 4. The method of claim 1, wherein said NO donor is delivered continuously. 5. The method of claim 1, wherein the NO donor is formulated in a unit dosage. 6. The method of claim 1, wherein the patient is treated to prevent a relapse of vulvodynia. 7. The method of claim 1, wherein the patient is human. 8. The method of claim 1, wherein the vulvar pain of vulvodynia is constant. 9. The method of claim 1, wherein the vulvar pain of vulvodynia is intermittent. 10. The method of claim 1, wherein the vulvar pain of vulvodynia is diffuse. 11. The method of claim 1, wherein the vulvar pain of vulvodynia is localized. 12. The method of claim 1, wherein the NO donor is delivered locally by topical application in a sustained release format. 13. The method of claim 1, wherein the method consists essentially of administering the NO donor. 14. The method of claim 12, wherein the NO donor is nitroglycerin.
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