A method for forming a three-dimensional, biocompatible, porous scaffold structure using a solid freeform fabrication technique (referred to herein as robocasting) that can be used as a medical implant into a living organism, such as a human or other mammal. Imaging technology and analysis is first
A method for forming a three-dimensional, biocompatible, porous scaffold structure using a solid freeform fabrication technique (referred to herein as robocasting) that can be used as a medical implant into a living organism, such as a human or other mammal. Imaging technology and analysis is first used to determine the three-dimensional design required for the medical implant, such as a bone implant or graft, fashioned as a three-dimensional, biocompatible scaffold structure. The robocasting technique is used to either directly produce the three-dimensional, porous scaffold structure or to produce an over-sized three-dimensional, porous scaffold lattice which can be machined to produce the designed three-dimensional, porous scaffold structure for implantation.
대표청구항▼
What is claimed is: 1. A method for making a three-dimensional, bio-compatible scaffold structure, comprising: designing a three-dimensional geometry of a scaffolding structure utilizing software implemented by a computer; said software selected from the group consisting of mass transport softwar
What is claimed is: 1. A method for making a three-dimensional, bio-compatible scaffold structure, comprising: designing a three-dimensional geometry of a scaffolding structure utilizing software implemented by a computer; said software selected from the group consisting of mass transport software and solid mechanics software to match a pre-selected property, said property selected from the group consisting of compressive modulus, compressive strength, porosity of the porous structure, tortuosity of the porous structure, and mass transport characteristics of the porous structure; and depositing a bio-compatible slurry as discrete elements in said three-dimensional geometry using a robocasting rapid-prototyping method to construct a three-dimensional, porous structure, said three-dimensional porous structure comprising macroporosity between approximately 0 and 80%, microporosity of said discrete elements between 0 and 70% and nanoporosity of said discrete elements between approximately 0 and 60%. 2. The method of claim 1 wherein said three-dimensional porous structure is selected from a face-centered cubic structure, a simple cubic structure, a modified face-centered cubic structure, and a non-periodic structure. 3. The method of claim 1 wherein said slurry comprises a powder and a solvent, said powder selected from a ceramic, a metal, a glass, a polymer, and a composite material. 4. The method of claim 3 wherein said powder is selected from a material selected from alumina, mullite, zirconia, silicon carbide, silicon nitride, zinc oxide, barium titanate, barium strontium titanate, lead zirconate titanate, kaolin, a hydroxyapatite, a hexaaluminate, tungsten, silver, molybdenum, stainless steel, thick-film pastes, epoxies, sol-gel materials, Al2O 3/TiCuSil, Al2O 3/Al, Al2O3/Mo, zirconia/mullite, a porous/dense lead zirconate titanate material, porous/dense alumina, and a lead-zirconate-titanate/polymer material. 5. The method of claim 4 wherein said solvent is water. 6. The method of claim 3 wherein the slurry additionally comprises an organic material to assist in characteristics selected from the curing rate, the drying rate and the mechanical properties. 7. The method of claim 1 wherein said three-dimensional porous structure has a compressive strength greater than 25 MPa. 8. The method of claim 1 wherein said three-dimensional porous structure has a compressive modulus greater than 5 GPa. 9. The method of claim 1 wherein said three-dimensional porous structure comprises at least two individual elements, said individual elements each having a geometry selected from a polyhedral geometry and a cylindrical rod geometry. 10. The method of claim 9 wherein said individual elements have at least one geometry selected from a cylindrical rod, and polyhedral geometrical constructs with a cross-sectional geometry selected from rectangular, rhombic, trapezoidal, triangular and variable cross-sectional geometries. 11. The method of claim 10 wherein said individual elements have a characteristic dimension between 0.05 mm and 3.0 mm. 12. The method of claim 1 wherein said three-dimensional porous structure has a characteristic length dimension from less than 1 mm to greater than 200 mm. 13. The method of claim 10 wherein said individual elements have variable compositions. 14. The method of claim 3 wherein the slurry additionally comprises a dopant of variable concentration in said slurry. 15. The method of claim 1 wherein said three-dimensional porous structure is further machined to produce an implantable structure. 16. The method of claim 1 wherein the discrete elements have a spacing between 0 and 1000 microns and pores with a diameter between 1 and approximately 10 microns. 17. A method for making a three-dimensional, biocompatible scaffold structure, comprising: designing, using imaging analysis utilizing software implemented by a computer, a three-dimensional geometry of a scaffolding structure; said software selected from the group consisting of mass transport software and solid mechanics software to match a pre-selected property, said property selected from the group consisting of compressive modulus, compressive strength, porosity of the porous structure, tortuosity of the porous structure, and mass transport characterstics of the porous structure; and depositing a biocompatible material as discrete elements in said three-dimensional geometry using a rapid-prototyping method to construct a three-dimensional, porous structure, said three-dimensional porous structure comprising macroporosity between approximately 0 and 80%, microporosity of said discrete elements between 0 and 70% and nanoporosity of said discrete elements between approximately 0 and 60%, said discrete elements having a spacing ranging between 300 microns to 1000 microns, said discrete elements having pores with diameters between 1 and 10 microns.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (22)
Riess Guido (Garmisch-Partenkirchen DEX) Geiger Albert (Garmisch-Partenkirchen DEX), Bone implant member for prostheses and bone connecting elements and process for the production thereof.
Hermansson Leif (Uppsala SEX) Forberg Sevald (Enskede SEX) Jiangou Li (Stockholm SEX), Composite ceramic material and method to manufacture the material.
Graves ; Jr. George A. (Bellbrook OH) McCullum Dale E. (Vandalia OH) Goodrich Steven M. (Dayton OH), Controlled pore size ceramics particularly for orthopaedic and dental applications.
Abrams Steven R. (New York NY) Korein James U. (Chappaqua NY) Srinivasan Vijay (Peekskill NY) Tarabanis Konstantinos (Flushing NY), Method employing sequential two-dimensional geometry for producing shells for fabrication by a rapid prototyping system.
Cormier Denis R. ; Taylor James B. ; West ; II Harvey A., Methods and apparatus for rapidly prototyping three-dimensional objects from a plurality of layers.
Mahmood, Tahir; Riesle, Jens Uwe; van Blitterswijk, Clemens Antoni, Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material.
Bradbury, Thomas J.; Gaylo, Christopher M.; Fairweather, James A.; Chesmel, Kathleen D.; Materna, Peter A.; Youssef, Adolphe, System and method for rapidly customizing design, manufacture and/or selection of biomedical devices.
Uthgenannt, Brian A.; Friend, Christopher W.; Durcholz, Bradley T.; Catanzarite, Joshua B.; Metzger, Robert; Worrell, Kai Robert, Backup surgical instrument system and method.
Jacobsen, Alan J.; Barvosa-Carter, William B.; Gross, Adam F.; Cumberland, Robert; Kirby, Kevin W.; Kisailus, David, Composite structures with ordered three-dimensional (3D) continuous interpenetrating phases.
Schuster, Luis, Device for the resection of bones, method for producing such a device, endoprosthesis suited for this purpose and method for producing such an endoprosthesis.
Schuster, Luis, Device for the resection of bones, method for producing such a device, endoprosthesis suited for this purpose and method for producing such an endoprosthesis.
Schuster, Luis, Device for the resection of bones, method for producing such a device, endoprosthesis suited for this purpose and method for producing such an endoprosthesis.
Serbousek, Jon C.; Davis, Todd O.; Catanzarite, Joshua B.; Uthgenannt, Brian A., Drill guides for confirming alignment of patient-specific alignment guides.
Borenstein, Jeffrey T.; Weinberg, Eli J.; Hsiao, James Ching-Ming; Khalil, Ahmad S.; Tupper, Malinda M.; Garcia-Cardena, Guillermo; Mack, Peter; Tao, Sarah L., Method of fabricating microfluidic structures for biomedical applications.
Walsh, Steven P.; Tudor, Letitia; Corrao, Ernest N.; Berky, Craig B.; Bauer, Jonathan P.; Hemingway, Jeremy; Axelrod, Michael, Methods of repairing a joint using a wedge-shaped implant.
Metzger, Robert; Schoenefeld, Ryan J.; Belcher, Nathan E.; Uthgenannt, Brian A., Patient specific alignment guide with cutting surface and laser indicator.
Meridew, Jason D.; Witt, Tyler D.; Schoenefeld, Ryan J.; Slone, W. Jason; Metzger, Robert; Lombardi, Adolph V.; Nycz, Jeffrey H.; Munsterman, Matthew D.; Wolfe, Alexander P.; Kabata, Tamon; Nairus, James G.; Clohisy, John C., Patient-specific acetabular guides and associated instruments.
Walsh, Steven P.; Tudor, Letitia; Corrao, Jr., Ernest N.; Berky, Craig B.; Bauer, Jonathan P.; Hemingway, Jeremy, Tapered joint implant and related tools.
Borenstein, Jeffrey T.; Weinberg, Eli J.; Hsiao, James C.; Khalil, Ahmad S.; Tupper, Malinda M.; Garcia-Cardena, Guillermo; Mack, Peter; Tao, Sarah L., microfluidic structures for biomedical applications.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.