Medical system, method and apparatus employing MEMS
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-061/32
B01D-061/24
출원번호
US-0031112
(2001-07-03)
국제출원번호
PCT/US01/021188
(2001-07-03)
§371/§102 date
20020114
(20020114)
국제공개번호
WO02/005059
(2002-01-17)
발명자
/ 주소
Cork,William H.
Ulmes,James J.
West,Richard L.
Lo,Ying Cheng
Weber,Mark C.
Min,Kyungyoon
출원인 / 주소
Baxter International Inc.
인용정보
피인용 횟수 :
7인용 특허 :
96
초록▼
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constitu
A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selected characteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
대표청구항▼
What is claimed is: 1. A biological suspension processing system comprising: a blood treatment device for treating one or more components of a biological suspension; a human subject; a first fluid flow path, wherein said first fluid flow path is in continuing, direct communication with the vascul
What is claimed is: 1. A biological suspension processing system comprising: a blood treatment device for treating one or more components of a biological suspension; a human subject; a first fluid flow path, wherein said first fluid flow path is in continuing, direct communication with the vascular system of the human subject and the treatment device for introducing blood from the human subject into the treatment device; a second fluid flow path communicating with the treatment device for withdrawing a constituent of the blood from the treatment device; a third fluid flow path communicating with the treatment device for withdrawing another constituent of the blood from the treatment device; at least one microelectromechanical sensor communicating with one of said fluid flow paths for sensing either a biological or a chemical characteristic of the fluid within the flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject and a controller adapted to receive signals from said sensor and control the blood treatment device in response thereto. 2. The system of claim 1 in which the sensor generates a signal responsive to one or more selected characteristics of the fluid in one of the fluid flow paths. 3. The system of claim 2 in which the third fluid flow path communicates with the human subject, the treatment device is adapted to add anticoagulant to the blood in the first fluid flow path, the selected characteristic includes the hematocrit of blood in the first fluid flow path, and the controller controls the addition of anticoagulant into the first fluid flow path. 4. The system of claim 2 in which the controller controls the treatment device in response to the signal to avoid one or more deleterious consequences to the human subject. 5. The system of claim 2 in which the controller controls the treatment device in response to the signal to withdraw a constituent of desired quality. 6. The system of claim 2 in which the controller controls the treatment device in response to the signal to withdraw a constituent of desired quantity. 7. The system of claim 2 in which the controller controls the treatment device in response to the signal to withdraw a constituent that is depleted of an undesired component. 8. The system of claim 7 in which the undesired component is white cells. 9. The system of claim 2 in which the controller controls the treatment device in response to the signal to withdraw a desired constituent. 10. The system of claim 9 in which the desired constituent is platelets. 11. The system of claim 9 in which the desired constituent is red cells or plasma. 12. The system of claim 2 in which the sensor senses platelets and the controller controls the treatment device to withdraw a selected minimum quantity of platelets. 13. The system of claim 1 further comprising a fluid management module carried by the first fluid flow path between the vascular system of the human subject and the treatment device, said fluid management module adapted to receive blood from the vascular system of the human subject via the first fluid flow path and control the amount of blood introduced into the treatment device. 14. The system of claim 1 further comprising a container communicating with the second fluid flow path for receiving the withdrawn constituent, the system being adapted to provide tracking information for associating with the container the particular characteristic sensed by at least one sensor. 15. The system of claim 14 in which the system further comprises machine readable or human readable data storage media carried by the container, the data storage media storing information regarding the particular characteristic sensed by at least one sensor. 16. The system of claim 15 in which the data storage media comprises a bar code label on the container. 17. The system of claim 15 in which the data storage media comprises an electronic data storage device. 18. The system of claim 17 in which the electronic data storage device has a non-volatile semiconductor memory. 19. The system of claim 15 in which the data storage media comprises at least one icon carried by the container and representative of the sensed characteristic. 20. The system of claim 15 in which the suspension includes one or more blood components and the blood component withdrawn is a cellular component, and the container is for storing the cellular component withdrawn, and the data storage media includes data regarding the type, quality, purity, quantity or concentration of the cellular blood component in the container. 21. A biological suspension processing system comprising: a blood treatment device for treating one or more components of a biological suspension; a human subject; a first fluid flow path, wherein said first fluid flow path is in continuing, direct communication with the vascular system of the human subject and the treatment device for introducing blood from the human subject into the treatment device; a first microelectromechanical sensor communicating with said first fluid flow path for sensing an initial condition of the fluid within said first fluid flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject, said first sensor further generating a signal responsive to the initial condition of the fluid in said first fluid flow path; a second fluid flow path communicating with the treatment device for withdrawing a constituent of the blood from the treatment device; a second microelectromechanical sensor communicating with said second fluid flow path for sensing either an in-process condition or a final product condition of the fluid within said second fluid flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject, said second sensor further generating a signal responsive to the in-process condition or final condition of the fluid in said second fluid flow path; and a controller adapted to receive the first and second sensor signals and to control the treatment device in response thereto. 22. The system of claim 21 in which the third fluid flow path communicates with the human subject, the treatment device is adapted to add anticoagulant to the blood in the first fluid flow path, the selected characteristic includes the hematocrit of blood in the first fluid flow path, and the controller controls the addition of anticoagulant into the first fluid flow path. 23. The system of claim 21 in which the controller controls the treatment device in response to the first or second sensor signal to avoid one or more deleterious consequences to the human subject. 24. The system of claim 21 in which the controller controls the treatment device in response to the first sensor signal to withdraw a constituent of desired quality. 25. The system of claim 21 in which the controller controls the treatment device in response to the second sensor signal to withdraw a constituent of a desired quantity. 26. The system of claim 21 in which the controller controls the treatment device in response to the first or second sensor signal to withdraw a constituent that is depleted of an undesired component. 27. The system of claim 21 in which the undesired component is white cells. 28. The system of claim 21 in which the controller controls the treatment device in response to the signal to withdraw a desired constituent. 29. The system of claim 28 in which the desired constituent is platelets. 30. The system of claim 28 in which the desired constituent is red cells or plasma. 31. The system of claim 21 in which the sensor senses platelets and the controller controls the treatment device to withdraw a selected minimum quantity of platelets. 32. The system of claim 21 further comprising a fluid management module carried by the first fluid flow path between the vascular system of the human subject and the treatment device, said fluid management module adapted to receive blood from the vascular system of the human subject via the first fluid flow path and control the amount of blood introduced into the treatment device. 33. The system of claim 21 further comprising a container communicating with the second fluid flow path for receiving the withdrawn constituent, the system being adapted to provide tracking information for associating with the container the particular characteristic sensed by at least one sensor. 34. The system of claim 33 in which the system further comprises machine readable or human readable data storage media carried by the container, the data storage media storing information regarding the particular characteristic sensed by at least one sensor. 35. The system of claim 34 in which the data storage media comprises at least one icon carried by the container and representative of the sensed characteristic. 36. The system of claim 34 in which the suspension includes one or more blood components and the blood component withdrawn is a cellular component, and the container is for storing the cellular component withdrawn, and the data storage media includes data regarding the type, quality, purity, quantity or concentration of the cellular blood component in the container. 37. The system of claim 33 in which the data storage media comprises a bar code label on the container. 38. The system of claim 33 in which the data storage media comprises an electronic data storage device. 39. The system of claim 38 in which the electronic data storage device has a non-volatile semiconductor memory. 40. A biological suspension processing system comprising: a blood treatment device for treating one or more components of a biological suspension; a human subject; a first fluid flow path, wherein said first fluid flow path is in continuing, direct communication with the vascular system of the human subject and the treatment device for introducing blood from the human subject into the treatment device; a first microelectromechanical sensor communicating with said first fluid flow path for sensing an initial condition of the fluid within said first fluid flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject, said first sensor further generating a signal responsive to the initial condition of the fluid in said first fluid flow path; a second fluid flow path communicating with the treatment device for withdrawing a constituent of the blood from the treatment device; a second microelectromechanical sensor communicating with said second fluid flow path for sensing either an in-process condition or a final product condition of the fluid within said second fluid flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject, said second sensor further generating a signal responsive to the in-process condition of the fluid in said second fluid flow path; a third fluid flow path communicating with the treatment device for withdrawing another constituent of the blood from the treatment device; a third microelectromechanical sensor communicating with said third fluid flow path for sensing a final product condition of the fluid within said third fluid flow path while said first fluid flow path is in continuing, direct communication with the vascular system of the human subject, said third sensor further generating a signal responsive to the final product condition of the fluid in said third fluid flow path; and a controller adapted to receive the first, second, and third sensor signals and to control the treatment device in response thereto. 41. The system of claim 40 further comprising a fluid management module carried by the first fluid flow path between the vascular system of the human subject and the treatment device, said fluid management module adapted to receive blood from the vascular system of the human subject via the first fluid flow path and control the amount of blood introduced into the treatment device. 42. The system of claim 40 further comprising a container communicating with the second fluid flow path for receiving the withdrawn constituent, the system being adapted to provide tracking information for associating with the container the particular characteristic sensed by at least one sensor. 43. The system of claim 40 in which the system further comprises machine readable or human readable data storage media carried by the container, the data storage media storing information regarding the particular characteristic sensed by at least one sensor. 44. The system of claim 43 in which the data storage media comprises a bar code label on the container. 45. The system of claim 44 in which the electronic data storage device has a non-volatile semiconductor memory. 46. The system of claim 43 in which the data storage media comprises an electronic data storage device. 47. The system of claim 43 in which the data storage media comprises at least one icon carried by the container and representative of the sensed characteristic. 48. The system of claim 43 in which the suspension includes one or more blood components and the blood component withdrawn is a cellular component, and the container is for storing the cellular component withdrawn, and the data storage media includes data regarding the type, quality, purity, quantity or concentration of the cellular blood component in the container.
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