초록 ▼

A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. M

A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface is also provided. One method involves: providing a structure comprising a porous material; contacting the structure comprising a porous material with a concentrating agent to disperse the concentrating agent throughout at least a portion of the porous material; contacting the structure comprising a porous material and the concentrating agent with a solution of a therapeutic agent; and removing the therapeutic agent from solution within the porous material at the locations of the concentrating agent. Another method involves multiple immersion steps without the use of a concentrating agent.

대표청구항 ▼

I claim: 1. A stent delivery system for delivering and deploying a stent within a body lumen, comprising: a catheter having a dilatation balloon disposed on a distal end thereof; and a stent disposed on the dilatation balloon, wherein the stent includes a porous material disposed on an outer surfac

I claim: 1. A stent delivery system for delivering and deploying a stent within a body lumen, comprising: a catheter having a dilatation balloon disposed on a distal end thereof; and a stent disposed on the dilatation balloon, wherein the stent includes a porous material disposed on an outer surface thereof having a precipitating agent and a therapeutic agent therein, wherein the precipitating agent is comprised of a material different from that of the therapeutic agent and has an affinity for the therapeutic agent. 2. The stent delivery system of claim 1, wherein the precipitating agent is selected from the group consisting of a binding agent, a sequestering agent and a nucleating agent. 3. The stent delivery system of claim 2, wherein the binding agent is a polycation. 4. The stent delivery system of claim 3, wherein the polycation is protamine. 5. The stent delivery system of claim 2, wherein the binding agent is a polyanion. 6. The stent delivery system of claim 5, wherein the polyanion is heparin sulfate. 7. The stent delivery system of claim 3, wherein the sequestering agent is heparin. 8. The stent delivery system of claim 3, wherein the sequestering agent is a cyclodextrin.