Delivery of rizatriptan or zolmitriptan through an inhalation route
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/12
A61K-009/14
A61M-015/00
출원번호
US-0792096
(2004-03-03)
발명자
/ 주소
Hale,Ron L.
Rabinowitz,Joshua D.
Solas,Dennis W.
Zaffaroni,Alejandro C.
출원인 / 주소
Alexza Pharmaceuticals, Inc.
대리인 / 주소
Swanson &
인용정보
피인용 횟수 :
49인용 특허 :
78
초록▼
The present invention relates to the delivery of headache and anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patien
The present invention relates to the delivery of headache and anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising rizatriptan or zolmitriptan to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
대표청구항▼
The invention claimed is: 1. A method of treating headache or migraine in a patient comprising administering a therapeutic amount of a rizatriptan condensation aerosol to the patient by inhalation, wherein the therapeutic amount of a rizatriptan condensation aerosol comprises between 1 mg and 20 mg
The invention claimed is: 1. A method of treating headache or migraine in a patient comprising administering a therapeutic amount of a rizatriptan condensation aerosol to the patient by inhalation, wherein the therapeutic amount of a rizatriptan condensation aerosol comprises between 1 mg and 20 mg of rizatriptan delivered in a single inspiration, and wherein the condensation aerosol is formed by heating a thin layer containing rizatriptan, on a solid support, to produce a vapor of rizatriptan, and condensing the vapor to form a condensation aerosol characterized by less than 10% rizatriptan degradation products by weight, and an MMAD of less than 5 microns. 2. A method of treating headache or migraine in a patient comprising administering a therapeutic amount of a zolmitriptan condensation aerosol to the patient by inhalation, wherein the therapeutic amount of a zolmitriptan condensation aerosol comprises between 0.5 mg and 10 mg of zolmitriptan delivered in a single inspiration, and wherein the condensation aerosol is formed by heating a thin layer containing zolmitriptan, on a solid support, to produce a vapor of zolmitriptan, and condensing the vapor to form a condensation aerosol characterized by less than 10% zolmitriptan degradation products by weight, and an MMAD of less than 5 microns. 3. A method of administering a dose form of rizatriptan to a patient comprising administering the dose form to the patient by inhalation, wherein the dose form comprises less than 4 mg of rizatriptan, and wherein the dose form further comprises a condensation aerosol formed by heating a thin layer containing rizatriptan, on a solid support, to produce a vapor of rizatriptan, and condensing the vapor to form a condensation aerosol characterized by less than 10% rizatriptan degradation products by weight, and an MMAD of less than 5 microns. 4. A method of administering a dose form of zolmitriptan to a patient comprising administering the dose form to the patient by inhalation, wherein the dose form comprises less than 1 mg of zolmitriptan, and wherein the dose form further comprises a condensation aerosol formed by heating a thin layer containing zolmitriptan, on a solid support, to produce a vapor of zolmitriptan, and condensing the vapor to form a condensation aerosol characterized by less than 10% zolmitriptan degradation products by weight, and an MMAD of less than 5 microns. 5. A method of administering a rizatriptan condensation aerosol to a patient comprising administering the rizatriptan condensation aerosol to the patient by inhalation, wherein the rizatriptan condensation aerosol is formed by heating a thin layer containing rizatriptan, on a solid support, to produce a vapor of rizatriptan, and condensing the vapor to form a condensation aerosol characterized by less than 5% rizatriptan N-oxide or didehydro rizatriptan by weight, and an MMAD of less than 5 microns. 6. A method of administering a zolmitriptan condensation aerosol to a patient comprising administering the zolmitriptan condensation aerosol to the patient by inhalation, wherein the zolmitriptan condensation aerosol is formed by heating a thin layer containing zolmitriptan, on a solid support, to produce a vapor of zolmitriptan, and condensing the vapor to form a condensation aerosol characterized by less than 5% zolmitriptan N-oxide or didehydro zolmitriptan by weight, and an MMAD of less than 5 microns.
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