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특허 상세정보

Process for the production of (-)-epigallocatechin gallate

국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C07D-311/04    C07D-311/00    C07D-311/26    C07D-311/62   
미국특허분류(USC) 549/399; 424/725; 424/729; 424/732; 424/738; 549/400; 549/401; 549/403
출원번호 US-0246112 (2002-09-18)
우선권정보 EP-99116032(1999-08-16)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Bryan Cave LLP
인용정보 피인용 횟수 : 1  인용 특허 : 10
초록

A process is provided for making (-)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regenerating the resin by desorbing the remaining catechins, and optionally concentrating the desorbed catechins.

대표
청구항

What is claimed is: 1. A process for producing (-)-epigallocatechin gallate (EGCG) comprising the steps of: a) providing a green tea extract containing tea catechins and caffeine; b) subjecting the green tea extract to chromatography on a macroporous polar resin at a temperature between about 40째 C. to about 60째 C.; and c) eluting the EGCG from the macroporous polar resin with a polar elution solvent at a temperature between about 40째 C. to about 60째 C. and at a pressure between about 0.1 bar to about 50 bar. 2. A process according to claim 1 fur...

이 특허에 인용된 특허 (10)

  1. Dawson-Ekeland Kari R. (Midland MI) Stringfield Richard T. (Midland MI). Decaffeination of liquid medium. USP1991065021253.
  2. Ekanayake Athula ; Bunger John Robert ; Mohlenkamp ; Jr. Marvin Joseph. Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color. USP1999035879733.
  3. Chung Fung L. (Yorktown Hts. NY). Inhibition of lung tumorigenesis by administration of a polyphenol. USP1995025391568.
  4. Bailey David T. ; Yuhasz Ralph L. ; Zheng BoLin. Method for isolation of caffeine-free catechins from green tea. USP2001046210679.
  5. Ahn Hee-Yul,KRX ; Park Jong-Bum,KRX ; Yun Yeo-Pyo,KRX ; Cho Myeong-Chan,KRX ; Kim Young-Gyu,KRX. Method for preventing or treating coronary restenosis with catechin. USP2001046214868.
  6. Cheng Shu Jun,JPX ; Wang De Chang,JPX ; Zhen Yong Su,JPX ; Nishino Hoyoku,JPX ; Hara Yukihiko,JPX. Method of increasing the effectiveness of anti-metabolites. USP1998095804567.
  7. Bragaglia Anthony Joseph. Nutraceutical composition for protection against solar radiation. USP2001076254898.
  8. Chang Stephen S. (E. Brunswick NJ) Bao Yongde (New Brunswick NJ). Process for manufacture of natural antioxidant products from tea and spent tea. USP1991085043100.
  9. Goers Steven K. (Ossining NY) Ghossi Parviz (Tarrytown NY) Patterson John T. (North Tarrytown NY) Young Cynthia L. (Brewster NY). Process for producing a green leaf essence. USP1989024806379.
  10. Hara Yukihiko (Shizuoka JPX). Process for the production of tea catechins. USP1986094613672.