Pharmaceutical compositions and methods for managing skin conditions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/40
A61K-031/35
A61K-031/495
출원번호
US-0093443
(2002-03-11)
발명자
/ 주소
Murad,Howard
출원인 / 주소
Murad,Howard
대리인 / 주소
Kenyon &
인용정보
피인용 횟수 :
32인용 특허 :
25
초록▼
This application relates to a stable pharmaceutical composition and methods for the cleansing of skin to facilitate the prevention, treatment, and management of skin conditions, such as seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral dermatitis, acne, impetigo and other inflammator
This application relates to a stable pharmaceutical composition and methods for the cleansing of skin to facilitate the prevention, treatment, and management of skin conditions, such as seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral dermatitis, acne, impetigo and other inflammatory skin conditions, and the like, including a sufficient amount of an acidic component of a hydroxyacid or tannic acid, or a pharmaceutically acceptable salt thereof, to exfoliate a portion of the skin, a sufficient amount of stabilized hydrogen peroxide to facilitate cleansing of the skin without substantial irritation thereof, and an antimicrobial agent including at least one of an antibacterial agent, antimicrobial agent, antiviral agent, anthelmintic, or a combination thereof, in an amount sufficient to inhibit or reduce microorganisms on the skin.
대표청구항▼
What is claimed is: 1. A skin cleansing pharmaceutical composition comprising: an acidic component comprising a hydroxy acid or tannic acid, or a pharmaceutically acceptable salt thereof, present in an amount greater than about 4 weight percent sufficient to exfoliate at least a portion of the skin
What is claimed is: 1. A skin cleansing pharmaceutical composition comprising: an acidic component comprising a hydroxy acid or tannic acid, or a pharmaceutically acceptable salt thereof, present in an amount greater than about 4 weight percent sufficient to exfoliate at least a portion of the skin; hydrogen peroxide in an amount sufficient to cleanse the skin without substantial irritation thereof; and metronidazole. 2. The pharmaceutical composition of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier or excipient. 3. The pharmaceutical composition of claim 1, wherein the acidic component comprises an alpha-hydroxy acid, beta-hydroxy acid, or tannic acid. 4. The pharmaceutical composition of claim 3, wherein the acidic component comprises glycolic acid, lactic acid, citric acid, salicylic acid, or tannic acid. 5. The pharmaceutical composition of claim 1, further comprising an amount of amphoteric surfactant and an amount of citric acid sufficient to inhibit hydrogen peroxide decomposition for at least three months. 6. The pharmaceutical composition of claim 5, wherein the amount of amphoteric surfactant and citric acid is sufficient to inhibit hydrogen peroxide decomposition at 40째 C. for at least three months. 7. The pharmaceutical composition of claim 1, wherein the acidic component is present in an amount from about 4 to 12 weight percent, the hydrogen peroxide is present in an amount from about 0.01 to 6 weight percent, and the metronidazole is present in an amount from about 0.01 to 1.5 weight percent, of the composition. 8. The pharmaceutical composition of claim 1, further comprising at least one of a surfactant, a stabilizer, a preservative, a moisturizer, anti-inflammatory agent, anti-oxidant, or a coloring agent, which together may be present in an amount from about 10.1 to 99.1 weight percent of the composition. 9. A gel, paste, cream, lotion, emulsion, or ointment comprising the pharmaceutical composition of claim 1.
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이 특허에 인용된 특허 (25)
Cook William J. (New York NY) Wisniewski Karen L. (Bound Brook NJ) Dixit Nagaraj S. (Plainsboro NJ) Rao Nandakumar S. (Hockessin DE), Acidic disinfectant all-purpose liquid cleaning composition.
Hall Larry (Nazareth PA) Chiang Michael Y. (Flemington NJ) Meyer Judith M. (Somerville NJ), Disinfectants and sanitizers with reduced eye irritation potential.
Bansemir Klaus (Langenfeld DEX) Disch Karlheinz (Haan DEX) Hachmann Klaus (Hilden DEX) Lehmann Rudolf (Leichlingen DEX) Biermann Manfred (Muelheim DEX) Schnegelberger Harald (Leichlingen DEX), Disinfectants and their use for disinfecting the skin and mucous membrane.
Dresdner ; Jr. Karl P. (235 W. 48th St. ; Apt. #18N New York City NY 10036) Dangman Kenneth H. (400 Riverside Dr. ; Apt. #1A New York City NY 10032) Jazlowiecki Edward A. (15 Sachems Trail West Simsb, Flexible protective medical gloves and methods for their use.
Burke Michael R. (Somerset NJ) Prencipe Michael (East Windsor NJ) Buchanan James M. (Mercerville NJ), High foaming rheologically stable non-irritating oral composition.
Choi, Jennifer Hagyoung Kang; Yang, Chunlin; Sun, Ying; Fang, Carrie H.; Hauschild, James E.; Creasey, Abla A., Medical devices with galvanic particulates.
Huang, Alexander L.; Wu, Gin, Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide.
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