IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0482845
(2002-07-05)
|
우선권정보 |
AT-A 1057/2001(2001-07-06) |
국제출원번호 |
PCT/AT02/000197
(2002-07-05)
|
§371/§102 date |
20040106
(20040106)
|
국제공개번호 |
WO03/003911
(2003-01-16)
|
발명자
/ 주소 |
- Schaupp,Lukas
- Pieber,Thomas
|
출원인 / 주소 |
- Schaupp,Lukas
- Pieber,Thomas
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
24 인용 특허 :
14 |
초록
▼
The invention relates to a method for measuring the concentration of substances in living organisms using microdialysis, whereby bodily fluid is mixed with a perfusate and passed through a membrane and a substance value is determined for the bodily fluid with the aid of a sensor unit. According to t
The invention relates to a method for measuring the concentration of substances in living organisms using microdialysis, whereby bodily fluid is mixed with a perfusate and passed through a membrane and a substance value is determined for the bodily fluid with the aid of a sensor unit. According to the invention, to allow for the limited transport through the membrane, so that the measured substance value differs from the actual substance value in the organism, a reference substance present in said organism with a known value is also measured after passing through the membrane and mixing with the perfusate and the actual substance value is determined, based on the quotient from the known reference substance value divided by the measured reference substance value, multiplied by the measured substance value.
대표청구항
▼
The invention claimed is: 1. Method for measuring the concentration of substances in living organisms using microdialysis, wherein bodily fluid is mixed with a perfusate and passed through a membrane, and a substance concentration of the bodily fluid is determined using a sensor unit, characterized
The invention claimed is: 1. Method for measuring the concentration of substances in living organisms using microdialysis, wherein bodily fluid is mixed with a perfusate and passed through a membrane, and a substance concentration of the bodily fluid is determined using a sensor unit, characterized in that in order to take into consideration the restricted transport of the substance through the membrane, so that the measured substance concentration differs from the actual substance concentration in the organism, an endogenous substance used as a reference substance, having a known value, is measured after passing through the membrane and mixing with the perfusate, and the actual substance concentration is determined on the basis of the quotient of the known reference substance value divided by the measured reference substance value, multiplied by the measured substance concentration. 2. Method according to claim 1, characterized in that any different transport behavior of the reference substance and the substance to be measured is taken into consideration by means of a correction factor that is determined in advance. 3. Method according to claim 2, characterized in that the correction factor is determined in advance, in vitro, by mixing a solution with ions and the substance to be determined, and passing it through a membrane. 4. Method according to claim 2, characterized in that the correction factor is determined in advance, in vivo, by measuring the substance value in the blood. 5. Method according to claim 1, characterized in that the measurement of the value to be determined is performed on the basis of measuring the electrical conductivity, corresponding to the sum of ions. 6. Method according to claim 1, characterized in that in order to achieve high flow-through rates, the perfusate or the mixture of perfusate/bodily fluid is pumped into and out of the body. 7. Device for measuring the concentration of substances in living organisms using microdialysis, having a microdialysis catheter that has a membrane, through which bodily fluid is mixed with a perfusate that is supplied from a perfusate reservoir, and having a sensor unit for determining the substance concentration of the bodily fluid, characterized in that the membrane is also set up for passage of an endogenous substance used as a reference substance, having a known value, and this reference substance is measured after passing through the membrane and mixing with the perfusate, using the sensor unit, and that the sensor unit is connected with an electronic evaluation unit, which is set up to determine the actual substance concentration on the basis of the quotient of the known reference substance value divided by the measured reference substance value, multiplied by the measured substance concentration. 8. Device according to claim 7, wherein a first pump unit is arranged on the inflow side of the microdialysis catheter, and a second pump unit is arrancred on the outflow side of the microdialysis catheter. 9. Device according to claim 8, wherein the first and the second pump units are synchronized. 10. Device according to claim 8, wherein the second pump unit on the outflow side is arranged behind the sensor unit, viewed in the flow direction. 11. Device according to claim 8, wherein the first and second pump units are peristalsis pumps. 12. Device according to claim 7, wherein the sensor unit has electrodes for determining the conductivity of the fluid that flows through.
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