IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0126733
(2002-04-22)
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발명자
/ 주소 |
- Muhlenberg,Lambert
- Struble,Chester
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출원인 / 주소 |
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인용정보 |
피인용 횟수 :
27 인용 특허 :
49 |
초록
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Techniques are described for estimating a rate of blood flow from a heart, such as a stroke volume or a cardiac output, as a function of a pressure in the heart. A pressure monitor may measure pressure values, and identify the times at which pressure values and valve opening and closing occur. The p
Techniques are described for estimating a rate of blood flow from a heart, such as a stroke volume or a cardiac output, as a function of a pressure in the heart. A pressure monitor may measure pressure values, and identify the times at which pressure values and valve opening and closing occur. The pressure monitor may estimate a velocity-time function as a function of the measured pressures and identified times, and may calculate a velocity-time integral by integrating the velocity-time function. The pressure monitor may also calculate an estimated velocity-time integral directly as a function of the measured pressures and the identified times. The pressure monitor may calculate the stroke volume or cardiac output using the velocity-time integral. The pressure monitor may control a delivery of therapy by an implantable medical device as a function of the stroke volume or cardiac output.
대표청구항
▼
The invention claimed is: 1. An implantable medical device comprising: an input circuit that receives a pressure signal representative of a pressure within a heart; and a processor that calculates a change in the pressure as a function of the pressure signal, and estimates a rate of blood flow from
The invention claimed is: 1. An implantable medical device comprising: an input circuit that receives a pressure signal representative of a pressure within a heart; and a processor that calculates a change in the pressure as a function of the pressure signal, and estimates a rate of blood flow from the heart as a function of the change in the pressure wherein the processor estimates a velocity-time integral as a function of the change in the pressure, and calculates the rate as a function of the velocity-time integral. 2. The device of claim 1, wherein the device is implanted in the upper chest of a patient. 3. The device of claim 1, wherein the rate is a stroke volume. 4. The device of claim 1, wherein the rate is a cardiac output. 5. The device of claim 1, further comprising a memory, wherein the processor stores the rate in the memory. 6. The device of claim 1, further comprising an input/output circuit coupled to the processor, the input/output circuit configured to exchange information between a person and the processor. 7. The device of claim 1, wherein the processor identifies a pressure value at a time of valve opening and a peak pressure value as a function of the pressure signal, and wherein the processor calculates the change in the pressure as a difference between the peak pressure value and the pressure value at the time of valve opening. 8. The device of claim 7, wherein the processor identifies a point of maximum positive slope of the pressure signal, and wherein the pressure value at the time of valve opening is a pressure value of the pressure signal at the point of maximum positive slope. 9. The device of claim 8, wherein the processor generates a differential signal that is representative of the first derivative of the pressure signal as a function of the pressure signal, and wherein the point of maximum positive slope of the pressure signal is a point of the pressure signal corresponding to a point of the differential signal where a maximum value of the differential signal occurs. 10. The device of claim 7, wherein the processor identifies a peak of the pressure signal, and wherein the peak pressure value is a pressure value at the peak. 11. The device of claim 1, wherein the processor estimates velocity data as a function of the change in pressure, and determines the rate as a function of the velocity data. 12. The device of claim 11, wherein the processor integrates the velocity data and determines the rate as a function of a result of the integration. 13. The device of claim 11, wherein the processor calculates a peak velocity as a function of the pressure signal, and estimates velocity data as a function of the peak velocity. 14. The device of claim 13, wherein the processor determines time data as a function of the pressure signal, and estimates the velocity data as a function of the peak velocity and the time data. 15. The device of claim 14, wherein the time data comprises a time of valve opening, a time of peak pressure and a time of valve closing, and wherein the processor estimates velocity data as a function of the peak velocity, the time of valve opening, the time of peak pressure and the time of valve closing. 16. The device of claim 15, wherein the pressure monitor identifies a point of maximum positive slope of the pressure signal, and wherein the time of valve opening is a time at the point of maximum positive slope. 17. The device of claim 16, wherein the processor generates a differential signal that is representative of the first derivative of the pressure signal as a function of the pressure signal, and wherein the point of maximum slope of the pressure signal is a point of the pressure signal corresponding to a point of the differential signal where a maximum value of the differential signal occurs. 18. The device of claim 15, wherein the processor identifies a peak of the pressure signal, and wherein the time of peak pressure is a time at which the peak occurs. 19. The device of claim 15, wherein the processor identifies a point of maximum negative slope of the pressure signal, and wherein the time of valve closing is a time at the point of maximum negative slope. 20. The device of claim 19, wherein the processor generates a differential signal that is representative of the first derivative of the pressure signal as a function of the pressure signal, and wherein the point of maximum negative slope of the pressure signal is a point of the pressure signal corresponding to a point of the differential signal where a minimum value of the differential signal occurs. 21. The device of claim 15, wherein the processor determines a time of peak velocity as a function of the time of peak pressure and estimates velocity data as a function of the time of valve opening, the time of peak velocity, the peak velocity and the time of valve closing. 22. The device of claim 1, wherein the processor determines time data as a function of the pressure signal, and estimates the rate as a function of the time data and the change in the pressure. 23. The device of claim 22, wherein the time data comprises a time of valve opening and a time of valve closing. 24. The device of claim 23, wherein the pressure monitor identifies a point of maximum positive slope of the pressure signal, and sets the time of valve opening as a time at the point of maximum positive slope. 25. The device of claim 24, wherein the processor generates a differential signal that is representative of the first derivative of the pressure signal as a function of the pressure signal, and wherein the point of maximum slope of the pressure signal is a point of the pressure signal corresponding to a point of the differential signal where a maximum value of the differential signal occurs. 26. The device of claim 23, wherein the processor identifies a point of maximum negative slope of the pressure signal, and sets the time of valve closing as a time at the point of maximum negative slope. 27. The device of claim 26, wherein the processor generates a differential signal that is representative of the first derivative of the pressure signal as a function of the pressure signal, and wherein the point of maximum negative slope of the pressure signal is a point of the pressure signal corresponding to a point of the differential signal where a minimum value of the differential signal occurs. 28. The device of claim 23, wherein the processor calculates a duration of a time period between the time of valve opening and the time of valve closing and estimates the rate as a function of the duration. 29. The device of claim 28, wherein the input circuit further receives an electrical activity signal, the electrical activity signal a function of electrical activity within the heart, and wherein the processor calculates a heart rate as a function of the electrical activity signal and determines the cardiac output as a function of the heart rate and the velocity-time integral.
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