IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0896004
(2001-06-29)
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발명자
/ 주소 |
- Nathan,Aruna
- Rosenblatt,Joel
- Arnold,Steven C.
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출원인 / 주소 |
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인용정보 |
피인용 횟수 :
12 인용 특허 :
46 |
초록
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The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax h
The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70째 C., as determined by differential scanning calorimetry.
대표청구항
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We claim: 1. A composition, comprising: a therapeutically effective amount of a therapeutic agent, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof and a monoglyceride, said monoglyceride selected from the group consisting of monostearoyl glycerol, monop
We claim: 1. A composition, comprising: a therapeutically effective amount of a therapeutic agent, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof and a monoglyceride, said monoglyceride selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, said polymeric wax comprising an aliphatic polyester backbone having monoglyceride groups pending therefrom and having a melting point less than about 70째 C., as determined by differential scanning calorimetry. 2. The composition of claim 1 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid and derivatives thereof. 3. The composition of claim 2 wherein said polybasic acid derivative is succinic anhydride. 4. The composition of claim 2 wherein said polybasic acid is succinic acid. 5. The composition of claim 1 wherein said polymeric wax has a number average molecular weight between about 1,000 g/mole and about 100,000 g/mole, as measured by gel permeation chromatography using polystyrene standards. 6. The composition of claim 1 further comprising an aliphatic polyester prepared from the group of monomers consisting of glycolide, L-lactide, D-lactide, meso-lactide, rac-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,4-dioxanone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and substituted derivatives thereof. 7. The composition of claim 1 wherein said polymeric wax has a melting point between about 25째 C. and about 70째 C. 8. A composition, comprising: a therapeutically effective amount of a therapeutic agent, and a polymeric wax copolymer comprising the reaction product of a fatty acid, a polyol, and at least two polybasic acids or derivatives thereof selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid and diglycolic anhydride, said polymeric wax copolymer comprising an aliphatic polyester backbone having fatty acid ester groups pending therefrom and having a melting point less than about 70째 C., as determined by differential scanning calorimetry. 9. The composition of claim 8 wherein said polymeric wax copolymer comprises the reaction product of said polybasic acid or derivative thereof, and at least two monoglycerides selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol. 10. The composition of claim 8 wherein said polymeric wax copolymer comprises the reaction product of said polybasic acid or derivative thereof, a monoglyceride selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monoolcoyl glycerol, and at least one additional polyol selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,3-propanediol, bis-2-hydroxyethyl ether, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, linear poly(ethylene glycol), branched poly(ethylene glycol), linear poly(propylene glycol), branched poly(propylene glycol), linear poly(ethylene-co-propylene glycol)s and branched poly(ethylene-co-propylene glycol)s. 11. A composition, comprising: a therapeutically effective amount of risperidone, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, said polymeric wax comprising an aliphatic polyester backbone having fatty acid ester groups pending therefrom and having a melting point less than about 70째 C., as determined by differential scanning calorimetry. 12. A composition, comprising: a therapeutically effective amount of a therapeutic agent, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, said polymeric wax comprising an aliphatic polyester backbone having fatty acid ester groups pending therefrom andilaving a melting point between about 25째 C. and about 70째 C., as determined by differential scanning calorimetry.
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