Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/44
A61K-009/58
A61K-009/52
A61K-031/4433
A61K-031/4427
출원번호
US-0322177
(2002-12-18)
발명자
/ 주소
Arnold,Steven
Nathan,Aruna
Rosenblatt,Joel
출원인 / 주소
Ethicon, Inc.
인용정보
피인용 횟수 :
20인용 특허 :
46
초록▼
The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wa
The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70째 C., as determined by differential scanning calorimetry, and an effective amount of rapamycin or an analogue thereof.
대표청구항▼
We claim: 1. A composition, comprising: an effective amount of rapamycin or an analogue thereof such that said composition functions as an immunosuppresant, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, said polymeric wax c
We claim: 1. A composition, comprising: an effective amount of rapamycin or an analogue thereof such that said composition functions as an immunosuppresant, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, said polymeric wax comprising an aliphatic polyester backbone having fatty acid ester groups pending therefrom and having a melting point less than about 70째 C., as determined by differential scanning calorimetry. 2. The composition of claim 1 wherein said polymeric wax comprises the reaction product of said polybasic acid or derivative thereof and a monoglyceride, said monoglyceride comprising the reaction product of said fatty acid and said polyol. 3. The composition of claim 1 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid and sebacic acid. 4. The composition of claim 2 wherein said monoglyceride is selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol. 5. The composition of claim 4 wherein said polybasic acid derivative is succinic anhydride. 6. The composition of claim 2 wherein said polymeric wax has a number average molecular weight between about 1,000 g/mole and about 100,000 g/mole, as measured by gel permeation chromatography using polystyrene standards. 7. The composition of claim 2 wherein said polymeric wax is branched.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (46)
Bezwada Rao S. (Whitehouse Station NJ) Jamiolkowski Dennis D. (Long Valley NJ), Absorbable polyoxaesters.
Casey ; Donald J. ; Gleckler ; George C., High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical compositio.
Jamiolkowski Dennis D. (Long Valley NJ) Bezwada Rao S. (Whitehouse Station NJ), Hydrogels of absorbable polyoxaesters containing amines or amido groups.
Scopelianos Angelo G. ; Arnold Steven C. ; Bezwada Rao S. ; Roller Mark B. ; Huxel Shawn T., Injectable microdipersions for soft tissue repair and augmentation.
Scopelianos Angelo G. (Whitehouse Station NJ) Arnold Steven C. (Sparta NJ) Bezwada Rao S. (Whitehouse Station NJ) Roller Mark B. (North Brunswick NJ) Huxel Shawn T. (Lakehurst NJ), Injectable microdispersions for soft tissue repair and augmentation.
Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Shalaby Shalaby W. (Anderson SC) Williams Bernard L. (Martinsville NJ), Liquid absorbable copolymers for parenteral applications.
Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Shalaby Shalaby W. (Anderson SC) Williams Bernard L. (Martinsville NJ), Liquid absorbable copolymers for parenteral applications.
Scopelianos Angelo G. (Whitehouse Station NJ) Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Gooding Richard D. (Easton PA), Liquid polymer filled envelopes for use as surgical implants.
Angelo G. Scopelianos ; Steven C. Arnold ; Rao S. Bezwada ; Mark B. Roller ; Shawn T. Huxel ; Robert J. Tannhauser, Microdispersions for coating surgical devices.
Gooch Jan W. (Gladstone MO) Bufkin B. George (Tipp City OH) Wildman Gary C. (Hattiesburg MS), Process for preparing coating binders from vegetable oil material.
Yamagata Yutaka,JPX ; Iga Katsumi,JPX ; Okada Hiroaki,JPX, Sustained releasable parenteral pharmaceutical preparations and method of producing the same.
Gruber Patrick Richard ; Kolstad Jeffrey John ; Witzke David Roy ; Hartmann Mark Henry ; Brosch Andrea Lee, Viscosity-modified lactide polymer composition and process for manufacture thereof.
Kleinman, David M.; Nivaggioli, Thierry; Gerritsen, Mary E.; Weber, David A., Formulations and methods for vascular permeability-related diseases or conditions.
Kleinman, David M.; Nivaggioli, Thierry; Gerritsen, Mary E.; Weber, David A., Formulations and methods for vascular permeability-related diseases or conditions.
Kleinman, David M.; Nivaggioli, Thierry; Gerritsen, Mary E.; Weber, David A., Formulations and methods for vascular permeability-related diseases or conditions.
Dor, Philippe J. M.; Mudumba, Sreenivasu; Nivaggioli, Thierry; Weber, David A.; Farooq, Sidiq; Takhar, Sudeep, Formulations for treating ocular diseases and conditions.
Mudumba, Sreenivasu; Dor, Philippe J M; Nivaggioli, Thierry; Weber, David A.; Farooq, Sidiq, Liquid formulations for treatment of diseases or conditions.
Mudumba, Sreenivasu; Dor, Philippe J M; Nivaggioli, Thierry; Weber, David A.; Farooq, Sidiq, Liquid formulations for treatment of diseases or conditions.
Mudumba, Sreenivasu; Dor, Philippe J M; Nivaggioli, Thierry; Weber, David A.; Farooq, Sidiq, Liquid formulations for treatment of diseases or conditions.
Kutryk, Michael J. B.; Cottone, Jr., Robert J.; Rowland, Stephen M., Medical device with coating for capturing genetically-altered cells and methods for using same.
Sun, Ying; Gosiewska, Anna; Nathan, Aruna; Wu, Jeffrey M., Topical gel compositions including poly(monostearoyl glycerol-co-succinate) polymer and methods for enhancing the topical application of a benefit agent.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.