Production scale method of forming microparticles
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B29B-009/02
A61K-009/14
A61K-009/16
B01J-002/04
B01J-002/02
출원번호
US-0784474
(2004-02-23)
발명자
/ 주소
Herbert,Paul F.
Healy,Michael S.
출원인 / 주소
Alkermes Controlled Therapeutics, Inc.
대리인 / 주소
Hamilton, Brook, Smith &
인용정보
피인용 횟수 :
0인용 특허 :
17
초록▼
The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is sur
The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.
대표청구항▼
What is claimed is: 1. A method for forming microparticles comprising the steps of: a) directing microdroplets of a mixture comprising a biocompatible polymer, a solvent for the polymer and a protein, peptide or small molecule, into a freezing section containing a liquefied gas, whereby the microdr
What is claimed is: 1. A method for forming microparticles comprising the steps of: a) directing microdroplets of a mixture comprising a biocompatible polymer, a solvent for the polymer and a protein, peptide or small molecule, into a freezing section containing a liquefied gas, whereby the microdroplets freeze; and b) contacting the frozen microdroplets in an extraction section with a liquid non-solvent to extract the solvent into the non-solvent thereby forming said microparticles; wherein the freezing section and extraction section are separated, and the non-solvent is in the liquid state throughout the method. 2. The method of claim 1, wherein the biocompatible polymer is biodegradable. 3. The method of claim 2, wherein said biocompatible and biodegradable polymer is selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(glycolic acid)s, polycarbonates, polyesteramides, polyanhydrides, poly(amino acids), polyorthoesters, polycaprolactone, poly(dioxanone)s, poly(alkylene alkylate)s, polyurethanes, blends and copolymers thereof. 4. The method of claim 3, wherein the polymer is a poly(lactide-co-glycolide). 5. The method of claim 1, wherein the temperature of step (b) is lower than the temperature of step (c). 6. The method of claim 1, wherein the liquefied gas is sprayed into the freezing section. 7. The method of claim 1, wherein the frozen microdroplets are collected at the bottom of the freezing section and directed into the extraction section. 8. A method for forming microparticles comprising the steps of: a) directing the microdroplets of a mixture comprising a biocompatible polymer, a solvent for the polymer and a protein, peptide or small molecule, into a freezing vessel containing a liquefied gas, whereby the microdroplets freeze; and b) contacting the frozen microdroplets in an extraction vessel with a liquid non-solvent to extract the solvent into the non-solvent thereby forming said microparticles; wherein the freezing vessel and extraction vessel are separated, and the non-solvent is in the liquid state throughout the method. 9. The method of claim 8, wherein the biocompatible polymer is biodegradable. 10. The method of claim 9, wherein said biocompatible and biodegradable polymer is selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(glycolic acid)s, polycarbonates, polyesteramides, polyanhydrides, poly(amino acids), polyorthoesters, polyacetals, polycyanoacrylates, polyetheresters, polycaprolactone, poly(dioxanone)s, poly(alkylene alkylate)s, polyurethanes, blends and copolymers thereof. 11. The method of claim 8, wherein the polymer is a poly(lactide-co-glycolide). 12. The method of claim 8, wherein the temperature of step (b) is lower than the temperature of step (c). 13. The method of claim 8, wherein the liquefied gas is sprayed into the freezing vessel. 14. The method of claim 8, wherein the frozen microdroplets are collected at the bottom of the freezing vessel and directed into the extraction vessel. 15. The method of claim 1, wherein the protein, peptide or small molecule is dissolved in the mixture. 16. The method of claim 1, wherein the protein, peptide or small molecule is suspended in the mixture. 17. The method of claim 1, wherein the protein, peptide or small molecule forms an emulsion in the mixture. 18. The method of claim 8, wherein the protein, peptide or small molecule is dissolved in the mixture. 19. The method of claim 8, wherein the protein, peptide or small molecule is suspended in the mixture. 20. The method of claim 8, wherein the protein, peptide or small molecule forms an emulsion in the mixture.
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이 특허에 인용된 특허 (17)
Fawzy Abdel A. (New Castle DE) Forestell Alferd J. (Newark DE), Apparatus and method for producing frozen particles of a liquid.
Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
Tice, Thomas R.; Lewis, Danny H.; Cowsar, Donald R.; Beck, Lee R., Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
Fermani Nicholas R. (Newark DE) Fletcher Mark G. (Newark DE), Method and apparatus for producing frozen particles using an entrapment zone of atomized cryogenic liquid droplets.
Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
Tice Thomas R. (Birmingham AL) Orsolini Piero (Martigny LA CHX) Schally Andrew V. (New Orleans LA), Process for increasing the antagonistic effect of peptidic compounds on hormone-dependent diseases.
Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
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