IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0168788
(2005-06-28)
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발명자
/ 주소 |
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출원인 / 주소 |
- Alcon Manufacturing, Ltd.
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인용정보 |
피인용 횟수 :
1 인용 특허 :
26 |
초록
The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.
대표청구항
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What is claimed is: 1. A method of enhancing the antimicrobial activity of an aqueous ophthalmic composition containing a borate compound selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof, which comprises including 0.01 to 2.
What is claimed is: 1. A method of enhancing the antimicrobial activity of an aqueous ophthalmic composition containing a borate compound selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof, which comprises including 0.01 to 2. 0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole in said composition. 2. A method according to claim 1, wherein the method further comprises adding 0.01 to 5.0% w/v of a polyol to the composition to further enhance its antimicrobial activity. 3. A method according to claim 2 wherein the polyol comprises propylene glycol. 4. A method according to claim 2, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof. 5. A method according to claim 4, wherein the polyol comprises sorbitol. 6. A method according to claim 5, wherein the polyol further comprises propylene glycol. 7. A method according to claim 2, wherein the borate concentration is 0.3 to 1.2% w/v and the polyol concentration is 0.6 to 2. 0% w/v. 8. A method according to claim 1, wherein the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP) , 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof. 9. A method according to claim 8, wherein the amino alcohol comprises AMP. 10. A method according to claim 9, wherein the method further comprises adding 0.01 to 5.0% of a polyol to the composition to further enhance the antimicrobial activity of the composition. 11. A method according to claim 10, wherein the borate concentration is 0.3 to 1.2% w/v and the polyol concentration is 0.6 to 2. 0% w/v. 12. A method according to claim 10, wherein the polyol comprises propylene glycol. 13. A method according to claim 10, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof. 14. A method according to claim 13, wherein the polyol comprises sorbitol. 15. A method according to claim 14, wherein the polyol further comprises propylene glycol. 16. A method according to claim 1, wherein the composition does not contain a conventional anti-microbial preservative. 17. A method according to claim 16, wherein the composition is adapted for use as an artificial tear. 18. A method according to claim 16, wherein the composition is adapted for use as an ocular lubricant. 19. A method of enhancing the antimicrobial activity of an aqueous contact lens disinfecting solution that contains an antimicrobial agent in an amount effective to disinfect a contact lens, which comprises including the following components in said solution: (a) 0.01 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole; and (b) a borate/polyol buffer system, said buffer system comprising a borate compound in an amount of 0.01 to 2.0% w/v and a polyol in an amount of 0.01 to 5.0% w/v. 20. A method according to claim 19, wherein the borate compound is selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; and the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof. 21. A method according to claim 20, wherein the amino alcohol comprises AMP. 22. A method of enhancing the antimicrobial activity of an aqueous, multi-dose ophthalmic composition, which comprises including the following components in said composition: (a) 0.1 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole; and (b) a borate/polyol buffer system, said buffer system comprising a borate compound in an amount of 0.01 to 2.0% w/v and a polyol in an amount of 0.01 to 5.0% w/v; wherein said composition is adapted for use as an artificial tear or ocular lubricant and does not contain a conventional anti-microbial preservative. 23. A method according to claim 22, wherein the borate compound is selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; and the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof. 24. A method according to claim 23, wherein the polyol comprises propylene glycol. 25. A method according to claim 23, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof. 26. A method according to claim 25, wherein the amino alcohol comprises AMP. 27. A method according to claim 25, wherein the polyol further comprises propylene glycol. 28. A method according to claim 27, wherein the amino alcohol comprises AMP. 29. A method according to claim 22, wherein the amino alcohol comprises AMP.
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