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Surface micromachined microneedles

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-005/32
출원번호 US-0787498 (1999-09-17)
국제출원번호 PCT/US99/021509 (1999-09-17)
§371/§102 date 20010316 (20010316)
국제공개번호 WO00/016833 (2000-03-30)
발명자 / 주소
  • Frazier,A. Bruno
  • Brazzle,John D.
출원인 / 주소
  • The University of Utah Research Foundation
대리인 / 주소
    Workman Nydegger
인용정보 피인용 횟수 : 41  인용 특허 : 37

초록

Surface micro-machined micro-needles (32) are formed as single needles (32) or in two-dimensional or three-dimensional micro-needle arrays (30). The micro-needles (32) are fabricated on a substrate (12) which can remain attached to the micro-needles (32) or can be subsequently removed. The two-dimen

대표청구항

What is claimed is: 1. A microneedle array device, comprising: a substrate having a substantially planar first surface and an edge adjacent said substantially planar first surface; and a plurality of hollow non-silicon microneedles positioned on said substantially planar first surface of said subst

이 특허에 인용된 특허 (37)

  1. Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
  2. Gerstel Martin S. (Palo Alto CA) Place Virgil A. (Palo Alto CA), Drug delivery device.
  3. DiFrancesco Lawrence (Hayward CA) Helber ; Jr. Carlyle L. (Fountain Valley CA), Electroformed high efficiency heat exchanger and method for making.
  4. Marks Gary T. (Phelps NY) McVeigh James H. (Webster NY) Sline Judy A. (Romulus NY) Wood Kenneth E. (Macedon NY), Electroformed multilayer spray director and a process for the preparation thereof.
  5. Schuler Frederick T. (Chatsworth CA) Flores Randolph (Simi Valley CA), Fluid-cooled channel construction.
  6. Lin Liwei (Berkeley CA) Pisano Albert P. (Berkeley CA), IC-processed microneedles.
  7. Lin Liwei ; Pisano Albert P., IC-processed microneedles.
  8. Miura Masayoshi (Kawasaki JPX) Akami Kenji (Kawasaki JPX) Oda Gen (Sagamihara JPX) Kojima Tamotsu (Kawasaki JPX) Naito Hiroshi (Machida JPX), Ink jet printer and method for fabricating a nozzle member.
  9. Pan Alfred I. T. (Mountain View CA), Ink jet printhead with self-aligned orifice plate and method of manufacture.
  10. Vladimir Gartstein ; Dragan Danilo Nebrigic ; Grover David Owens ; Faiz Feisal Sherman ; Vadim Vladimirovich Yuzhakov, Intracutaneous microneedle array apparatus.
  11. Tousignant Lew A. (St. Paul MN) Hoopman Timothy L. (River Falls WI) Thompson Kenneth C. (Stillwater MN), Jet impingment plate and method of making.
  12. Sexton Richard W. (Dayton OH), Laminate, electroformed ink jet orifice plate construction.
  13. Shuji Koyama JP; Junji Tatsumi JP; Ken Ikegame JP; Hiroaki Mihara JP; Miki Ito JP, Method for manufacturing orifice plate and liquid discharge head.
  14. Kaartinen Niilo (Vuolahti SF-21620 Kuusisto FIX), Method for producing a heatable and refrigerable element for a system handling small quantities of liquid, and an elemen.
  15. Becker Erwin (Karlsruhe DEX) Ehrfeld Wolfgang (Karlsruhe DEX) Mnchmeyer Dietrich (Weingarten DEX) Betz Hans (Munich DEX) Heuberger Anton (Munich DEX), Method for producing separating nozzle elements for the separation of fluid mixtures.
  16. Boris Stoeber ; Dorian Liepmann, Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby.
  17. Shiga Tatsuhide (Zushi JPX) Tsuruoka Yoshihiro (Yokohama JPX) Suzuki Motoo (Yokohama JPX), Method of making a fluid circuit device.
  18. Eriguchi Koji,JPX ; Kubota Masafumi,JPX ; Niwa Masaaki,JPX ; Nomura Noboru,JPX, Method of making aggregate of semiconductor micro-needles.
  19. Byers Charles L. (Granada Hills CA) Schulman Joseph H. (Granada Hills CA) Whitmoyer David I. (Los Angeles CA), Method of making an electrode array.
  20. Wolf Dietmar (Siegertsbrunn DEX) Tuscher Otto (Oberschleissheim DEX), Method of producing closed canals in components such as heat exchangers and rocket combustion chamber walls.
  21. Frazier A. Bruno, Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces.
  22. Frazier A. Bruno, Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces.
  23. Wood, Robert L.; Wynands, Henry A.; Markus, Karen W., Methods of fabricating microneedle arrays using sacrificial molds.
  24. Saito Tamio (Tokyo JPX) Sekiguchi Tadashi (Tochigi JPX), Microchannel plate and a method for manufacturing the same.
  25. Reed Michael L. (Pittsburgh PA) Weiss Lee E. (Pittsburgh PA), Micromechanical barb and method for making the same.
  26. Prausnitz, Mark R.; Allen, Mark G.; McAllister, Devin V.; Henry, Sebastien, Microneedle device for transport of molecules across tissue.
  27. Mark G. Allen ; Mark R. Prausnitz ; Devin V. McAllister ; Florent Paul Marcel Cros, Microneedle devices and methods of manufacture and use thereof.
  28. Pisano Albert P. ; Lebouitz Kyle S., Microneedle with isotropically etched tip, and method of fabricating such a device.
  29. Tsung Pan Alfred I. (Mountain View CA), Monolithic thermal ink jet printhead with integral nozzle and ink feed.
  30. Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
  31. Munoz Marcelino P., One-sided photoetching process for needle fabrication.
  32. Ozbay Ekmel (Ames IA) Tuttle Gary (Ames IA) Michel Erick (Ames IA) Ho Kai-Ming (Ames IA) Biswas Rana (Ames IA) Chan Che-Ting (Ames IA) Soukoulis Costas (Ames IA), Periodic dielectric structure for production of photonic band gap and method for fabricating the same.
  33. Lam Si-Ty (Pleasanton CA) Taub Howard H. (San Jose CA), Process for manufacturing thermal ink jet printheads having metal substrates and printheads manufactured thereby.
  34. Hoopman Timothy L. (River Falls WI) Johnson Dee L. (Woodbury MN) Krinke Harlan L. (May Township ; Washington County MN), Sheet-member containing a plurality of elongated enclosed electrodeposited channels and method.
  35. Jang Kwang K. (Kyungki-Do KRX), Skin perforating device for transdermal medication.
  36. Hindman Gregory T. (Albany OR), Thin-film structure method of fabrication.
  37. Gross Joseph (Moshav Mazor ILX) Zucker Shlomo (Mihmoret ILX), Transdermal or interdermal drug delivery devices.

이 특허를 인용한 특허 (41)

  1. Kawazoe, Hiroshi; Akai, Kunihiko; Yasue, Kiyoshi, Analytical pretreatment device.
  2. Kawazoe, Hiroshi; Akai, Kunihiko; Yasue, Kiyoshi, Analytical pretreatment device.
  3. Robinson, Stanley, Carbon-based apparatus for cooling of electronic devices.
  4. Ross, Russell Frederick, Composite microneedle array including nanostructures thereon.
  5. Ross, Russell Frederick, Composite microneedle array including nanostructures thereon.
  6. Burnett, Daniel Rogers; Hermanson, Christopher; Ahlman, James H.; Strul, Bruno, Cooling systems and methods for conductive coils.
  7. Ross, Russell Frederick, Device for delivery of rheumatoid arthritis medication.
  8. Ross, Russell Frederick, Device for delivery of rheumatoid arthritis medication.
  9. Ross, Russell Frederick, Injection molded microneedle array and method for forming the microneedle array.
  10. Ross, Russell Frederick, Medical devices for delivery of siRNA.
  11. Ross, Russell Frederick, Medical devices for delivery of siRNA.
  12. Burnett, Daniel R.; Hermanson, Christopher; Ahlman, James H.; Strul, Bruno, Method and apparatus for electrical stimulation therapy.
  13. Burnett, Daniel Rogers; Hermanson, Christopher, Method and apparatus for magnetic induction therapy.
  14. Burnett, Daniel Rogers; Hermanson, Christopher, Method and apparatus for magnetic induction therapy.
  15. Rajguru, Amit; Burnett, Daniel R., Method and apparatus for transdermal stimulation over the palmar and plantar surfaces.
  16. Rajguru, Amit; Burnett, Daniel R., Method and apparatus for transdermal stimulation over the palmar and plantar surfaces.
  17. Ross, Russell Frederick, Method for increasing the permeability of an epithelial barrier.
  18. Smith, Alan; Eppstein, Jonathan A.; Messier, Bernadette; Novakovic, Zoran; McRae, Stuart, Method for transdermal delivery of permeant substances.
  19. Smith, Alan; Eppstein, Jonathan A.; Messier, Bernadette; Novakovic, Zoran; McRae, Stuart, Method for transdermal delivery of permeant substances.
  20. Burnett, Daniel R., Methods and devices for performing electrical stimulation to treat various conditions.
  21. Burnett, Daniel R., Methods and devices for performing electrical stimulation to treat various conditions.
  22. Burnett, Daniel R., Methods and devices for performing electrical stimulation to treat various conditions.
  23. Kawazoe, Hiroshi; Nakaso, Akishi; Arike, Shigeharu, Micro fluid system support and manufacturing method thereof.
  24. Kawazoe, Hiroshi; Nakaso, Akishi; Arike, Shigeharu, Micro fluid system support and manufacturing method thereof.
  25. Hegde, Anant V.; Rajguru, Amit; Burnett, Daniel Rogers; Hermanson, Christopher, Microneedle electrode.
  26. Yeshurun, Yehoshua; Hefetz, Mier; De Boer, Meint; Berenschot, Erwin J W; Gardeniers, Hans, Microneedle structure and production method therefor.
  27. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  28. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  29. Yeung, King Lun; Wong, Ling Wai; Sun, Wenqing; Leung, Wai Kin; Lai, Wing Yan; Chan, Ngar Wai, Molecular sieve and zeolite microneedles and preparation thereof.
  30. Ross, Russell Frederick, Nanopatterned medical device with enhanced cellular interaction.
  31. Singh, Parminder; Worsham, Robert Wade; Trautman, Joseph C.; Bayamov, Danir; Bowers, Danny Lee; Klemm, Andrew Richard; Klemm, Steven Richard; Chen, Guohua, Solvent-cast microprotrusion arrays containing active ingredient.
  32. Ross, Russell F., Transdermal delivery of high viscosity bioactive agents.
  33. Ross, Russell F., Transdermal delivery of high viscosity bioactive agents.
  34. Ross, Russell Frederick; Baker, Andrew, Transdermal device containing microneedles.
  35. Eppstein, Jonathan; McRae, Stuart, Transdermal integrated actuator device, methods of making and using same.
  36. Eppstein, Jonathan; McRae, Stuart, Transdermal integrated actuator device, methods of making and using same.
  37. Eppstein, Jonathan; McRae, Stuart, Transdermal integrated actuator device, methods of making and using same.
  38. Ross, Russell F., Transdermal patch containing microneedles.
  39. McRae, Stuart; Bowerman, Wendy E.; Braun, Stephen Wilson; Spiehl, Regina; Messier, Bernadette; Farquhar, David; Henkel, Erin Koch; O'Leary, Jeremiah Peter; Fisher, Mark James; Kascak, Uros; Lantz, Loren J.; Novakovic, Zoran; Eppstein, Jonathan, Transdermal porator and patch system and method for using same.
  40. Messier, Bernadette; Novakovic, Zoran; O'Leary, Jeremiah Peter; Spiehl, Regina; Bowerman, Wendy E.; Braun, Stephen Wilson; Eppstein, Jonathan; Farquhar, David; Fisher, Mark James; Kascak, Uros; Henkel, Erin Koch; Lantz, Loren J.; McRae, Stuart, Transdermal porator and patch system and method for using same.
  41. Messier, Bernadette; Novakovic, Zoran; O'Leary, Jeremiah Peter; Spiehl, Regina; Bowerman, Wendy E.; Braun, Stephen Wilson; Eppstein, Jonathan; Farquhar, David; Fisher, Mark James; Kascak, Uros; Henkel, Erin Koch; Lantz, Loren J.; McRae, Stuart, Transdermal porator and patch system and method for using same.
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