Computer-assisted means for assessing lifestyle risk factors
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G06F-019/00
G06F-007/06
G06N-003/12
G06N-003/00
출원번호
US-0771933
(2001-01-30)
발명자
/ 주소
Gill Garrison,Rosalynn D.
Martin,Christopher J.
Sanchez Felix,Manuel V.
출원인 / 주소
Sciona Limited
대리인 / 주소
Nixon &
인용정보
피인용 횟수 :
44인용 특허 :
84
초록▼
The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determi
The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan.
대표청구항▼
The invention claimed is: 1. A computer assisted method of providing a personalized lifestyle advice plan for a human subject comprising: (i) providing a first dataset on a data processing device, said first dataset comprising information correlating the presence of individual alleles known to be a
The invention claimed is: 1. A computer assisted method of providing a personalized lifestyle advice plan for a human subject comprising: (i) providing a first dataset on a data processing device, said first dataset comprising information correlating the presence of individual alleles known to be associated with increased or decreased disease susceptibility, with a lifestyle risk factor; (ii) providing a second dataset on a data processing device, said second dataset comprising information matching each said risk factor with at least one lifestyle recommendation; (iii) inputting a third dataset identifying alleles present in said subject, wherein said alleles are one or more of the alleles of said first dataset; (iv) determining the risk factors associated with said alleles present in said human subject by correlating said alleles with risk factors provided by said first dataset; (v) determining at least one lifestyle recommendation based on each identified risk factor from step (iv) by matching said risk factor with a lifestyle recommendation from said second dataset; and (vi) generating a personalized lifestyle advice plan based comprising at least one lifestyle recommendation determined in step (v), wherein said personalized lifestyle advice plan includes recommended minimum and/or maximum amounts of food subtypes. 2. The method according to claim 1 wherein the method comprises the step of delivering the plan to the client. 3. The method according to claim 2 wherein the plan is delivered via the Internet and accessible via a unique identifier code. 4. The method according to claim 3 wherein the plan comprises hyperlinks to one or more Web pages. 5. The method according to claim 1 wherein said first dataset comprises information relating to two or more alleles of a gene selected from the group comprising: (a) a gene that encodes an enzyme responsible for detoxification of xenobiotics in Phase I metabolism; (b) a gene that encodes an enzyme responsible for conjugation reactions in Phase II metabolism; (c) a gene that encodes an enzyme that helps cells to combat oxidative stress; (d) a gene associated with micronutrient deficiency; and (e) a gene that encodes an enzyme responsible for metabolism of alcohol. (f) a gene that encodes an enzyme involved in lipid and/or cholesterol metabolism; (g) a gene that encodes an enzyme involved in clotting; (h) a gene that encodes a trypsin inhibitor; (i) a gene that encodes an enzyme related to susceptibility to metal toxicity; (j) a gene which encodes a protein required for normal cellular metabolism and growth; (k) a gene which encodes a HLA Class 2 molecule. 6. The method according to claim 5 wherein said first dataset comprises information relating to two or more alleles of a gene selected from each member of the group comprising: (a) a gene that encodes an enzyme responsible for detoxification of xenobiotics in Phase I metabolism; (b) a gene that encodes an enzyme responsible for conjugation reactions in Phase II metabolism; (c) a gene that encodes an enzyme that helps cells to combat oxidative stress; (d) a gene associated with micronutrient deficiency; and (e) a gene that encodes an enzyme responsible for metabolism of alcohol. (f) a gene that encodes an enzyme involved in lipid and/or cholesterol metabolism; (g) a gene that encodes an enzyme involved in clotting; (h) a gene that encodes a trypsin inhibitor; (i) a gene that encodes an enzyme related to susceptibility to metal toxicity; (j) a gene which encodes a protein required for normal cellular metabolism and growth; (k) a gene which encodes a HLA Class 2 molecule. 7. The method according to claim 5 wherein said first dataset comprises information relating to two or more alleles of a gene encoding an enzyme selected from the group comprising: cytochrome P450 monooxygenase, N-acetyltransferase 1, N-acetyltransferase 2, glutathione-S-transferase, manganese superoxide dismutase, 5,10-methylenetetrahydrofolatereductase and alcohol dehydrogenase 2. 8. The method according to claim 7 wherein said first dataset comprises information relating to two or more alleles of each of the genes encoding cytochrome P450 monooxygenase, N-acetyltransferase 1, N-acetyltransferase 2, glutathione-S-transferase, manganese superoxide dismutase, 5,10-methylene-tetrahydrofolatereductase and alcohol dehyd rogenase 2. 9. The method of claim 8 wherein said alleles are alleles of genes selected from the group consisting of the MTHFR gene, the MnSOD gene, the CYP1A1 gene, the GSTμ gene, GSTπ gene, the GSTΘ θgene and the ALDH2 gene. 10. The method according to claim 1 including the step determining the presence of individual alleles in a DNA sample of said human subject, and constructing the dataset used in step (iii) using results of said determination. 11. The method according to claim 10 wherein said presence of said individual alleles is determined by hybridisation with allele-specific oligonucleotides. 12. The method according to claim 11 wherein said allele specific oligonucleotides are selected from oligonucleotides each specific for one of the genes selected from the group comprising the CYP1A1 gene, the GSTμ gene, the GSTπ gene, the GSTΘθ gene, the NAT1 gene, the NAT2 gene, the MnSOD gene, the MTHFR gene and the ALDH2 gene. 13. The method of claim 1 wherein said first dataset and said second dataset are provided on the same data processing device. 14. A computer assisted method of providing a personalized lifestyle advice plan for a human subject comprising: (i) providing a first dataset on a data processing device, said first dataset comprising information correlating the presence of individual alleles known to be associated with increased or decreased disease susceptibility, with a lifestyle risk factor; (ii) providing a second dataset on a data processing device, said second dataset comprising information matching each said risk factor with at least one lifestyle recommendation; (iii) inputting a third dataset identifying alleles present in said subject, wherein said alleles are two or more of the alleles of said first; (iv) determining the risk factors associated with said alleles present in said human subject by correlating said alleles with risk factors provided by said first dataset; (v) determining at least one lifestyle recommendation based on each identified risk factor from step (iv) by matching said risk factor with a lifestyle recommendation from said second dataset; and (vi) generating a personalized lifestyle advice plan based comprising at least one lifestyle recommendation determined in step (v), wherein said personalized lifestyle advice plan includes recommended minimum and/or maximum amounts of food subtypes. 15. The method according to claim 14 wherein the method comprises the step of delivering the plan to the client. 16. The method according to claim 15 wherein the plan is delivered via the Internet and accessible via a unique identifier code. 17. The method according to claim 16 wherein the plan comprises hyperlinks to one or more Web pages. 18. The method according to claim 14 wherein said first dataset comprises information relating to two or more alleles of two or more genes selected from the group comprising: (a) a gene that encodes an enzyme responsible for detoxification of xenobiotics in Phase I metabolism; (b) a gene that encodes an enzyme responsible for conjugation reactions in Phase II metabolism; (c) a gene that encodes an enzyme that help cells to combat oxidative stress; (d) a gene associated with micronutrient deficiency; and (e) a gene that encodes an enzyme responsible for metabolism of alcohol. (f) a gene that encodes an enzyme involved in lipid and/or cholesterol metabolism; (g) a gene that encodes an enzyme involved in clotting; (h) a gene that encodes a trypsin inhibitor; (i) a gene that encodes an enzyme related to susceptibility to metal toxicity; (j) a gene which encodes a protein required for normal cellular metabolism and growth; (k) a gene which encodes a HLA Class 2 molecule. 19. The method according to claim 18 wherein said first dataset comprises information relating to two or more alleles of a gene selected from each member of the group comprising: (a) a gene that encodes an enzyme responsible for detoxification of xenobiotics in Phase I metabolism; (b) a gene that encodes an enzyme responsible for conjugation reactions in Phase II metabolism; (c) a gene that encodes an enzyme that help cells to combat oxidative stress; (d) a gene associated with micronutrient deficiency; and (e) a gene that encodes an enzyme responsible for metabolism of alcohol. (f) a gene that encodes an enzyme involved in lipid and/or cholesterol metabolism; (g) a gene that encodes an enzyme involved in clotting; (h) a gene that encodes a trypsin inhibitor; (i) a gene that encodes an enzyme related to susceptibility to metal toxicity; (j) a gene which encodes a protein required for normal cellular metabolism and growth; (k) a gene which encodes a HLA Class 2 molecule. 20. The method according to claim 18 wherein said first dataset comprises information relating to two or more alleles of of a gene encoding an enzyme selected from the group comprising: cytochrome P450 monooxygenase, N-acetyltransferase 1, N-acetyltransferase 2, glutathione-S-transferase, manganese superoxide dismutase, 5,10-methylenetetrahydrofolatereductase and alcohol dehydrogenase 2. 21. The method according to claim 20 wherein said first dataset comprises information relating to two or more alleles of each of the genes encoding cytochrome P450 monooxygenase, N-acetyltransferase 1, N-acetyltransferase 2, glutathione-S-transferase, manganese superoxide dismutase, 5,10-methylenetetrahydrofolatereductase and alcohol dehydrogenase 2. 22. The method of claim 21 wherein said alleles are alleles of genes selected from the group consisting of the MTHFR gene, the MnSOD gene, the CYP1A1 gene, the GSTμ gene, GSTTπ gene, the GSTΘ θgene and the ALDH2 gene. 23. The method according to claim 14 including the step determining the presence of individual alleles in a DNA sample of said human subject, and constructing the dataset used in step (iii) using results of said determination. 24. The method according to claim 23 wherein said presence of said individual alleles is determined by hybridisation with allele-specific oligonucleotides. 25. The method according to claim 24 wherein said allele specific oligonucleotides are selected from oligonucleotides each specific for two of the genes selected from the group comprising the CYP1A1 gene, the GSTμ gene, the GSTπ gene, the GSTΘθ gene, the NAT1 gene, the NAT2 gene, the MnSOD gene, the MTHFR gene and the ALDH2 gene. 26. The method of claim 14 wherein said first dataset and said second dataset and provided on the same data processing device.
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