Nitrophenol resins based upon various support materials. The nitrophenol resins are prepared by amide bond formation between a hydroxyl nitro benzoic acid and an aminoalkyl polymer support.
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What is claimed is: 1. Nitrophenol resins on a support selected from compounds of the following formula: wherein one of R1, R2, R3, R 4, and R5 is OH; at least one of R1, R2, R3, R 4, and R5 is NO2; the R1, R2, R3, R4 and R5 that are not OH or NO2 are selected from the group consisting of hydroge
What is claimed is: 1. Nitrophenol resins on a support selected from compounds of the following formula: wherein one of R1, R2, R3, R 4, and R5 is OH; at least one of R1, R2, R3, R 4, and R5 is NO2; the R1, R2, R3, R4 and R5 that are not OH or NO2 are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl groups, and substituted and unsubstituted aryl groups; and is a solid support. 2. The nitrophenol resin according to claim 1 wherein the solid support is selected from the group consisting of polystyrene, Tantagel, polyethylene glycol dimethacrylamide copolymers, macroporous resins, and silica gel. 3. A method for synthesizing nitrophenol resins according to claim 1 comprising forming amide bonds between hydroxynitrobenzoic acids and an amino-alkyl polymer support. 4. The method according to claim 3 wherein the coupling scheme is 1,3-diisopropylcarbodiimide-1-hydroxybenzotriazole and 1-hydroxybenxotriazole. 5. The method according to claim 3 wherein the coupling occurs in a solvent selected from the group consisting of N,N-dimethyl formamide, 1-methyl-2pyrrolidinome tetrahydrofurene, and methylene chloride. 6. A method for synthesizing nitrophenol resins according to claim 1 comprising hydrolyzing chlorobenzene. 7. The method according to claim 6 wherein an alkylamino resin is coupled with 4-chloro-3-nitrobenzoic acid. 8. A method for preparing carboxyl ester resins comprising reacting an acyl halide with a nitrophenol resin on a support selected from compounds of the following formula: wherein one of R1, R2, R3, R4 and R5 is OH; at least one of R1, R2, R3, R4 and R5 is NO2; the R1, R2, R3, R4 and R5 that are not OH or NO2 are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl groups, and substituted and unsubstituted aryl groups; and is a solid support. 9. A method for preparing sulfonyl ester resins comprising reacting a sulfonyl halide with a nitrophenol resin on a support selected from compounds of the following formula: wherein one of R1, R2, R3, R4 and R5 is OH; at least one of R1, R2, R3, R4 and R5 is NO2; the R1, R2, R3, R4 and R5 that are not OH or NO2 are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl groups, and substituted and unsubstituted aryl groups; and is a solid support. 10. A method for preparing amides comprising reacting an amine with a carboxyl ester resin produced according to claim 8. 11. The method according to claim 10 wherein the amine is selected from the group consisting of 1-cyclohexylpiperazine, 1-(2-pyridyl)piperazine, dimethylamine, 6-amino-l-hexanol, (S)-(+)-leucinol, n-butylamine, phenethylamine, (R)-(+)-(naphthyl)ethylamine, octylamine, and decylamine.
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이 특허에 인용된 특허 (3)
Summerton James (Corrvallis OR) Weller Dwight (Corrvallis OR), Polynucleotide assay reagent and method.
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