Medical device with array of electrode-containing reservoirs
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/22
A61N-001/30
출원번호
US-0886405
(2004-07-07)
발명자
/ 주소
Santini, Jr.,John T.
Cima,Michael J.
Langer,Robert S.
출원인 / 주소
Massachusetts Institute of Technology
대리인 / 주소
Sutherland Asbill &
인용정보
피인용 횟수 :
31인용 특허 :
59
초록▼
Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating
Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.
대표청구항▼
We claim: 1. A device for use in medical diagnostics comprising: a substrate; an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface; a plurality of electrodes located at least partially inside the reservo
We claim: 1. A device for use in medical diagnostics comprising: a substrate; an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface; a plurality of electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering the openings in the reservoirs; and control circuitry for selectively disintegrating or permeabilizing the reservoir cap over the opening of at least one of the reservoirs. 2. The device of claim 1, further comprising a diagnostic reagent in the interior of the reservoirs. 3. The device of claim 1, wherein the electrodes are located on sidewalls of the reservoirs. 4. The device of claim 1, wherein the electrodes comprise a thin film of a conducting metal or doped semiconductor. 5. The device of claim 1, wherein the reservoir caps comprise a metal. 6. The device of claim 1, wherein the substrate comprises silicon. 7. The device of claim 1, wherein the control circuitry is adapted to deliver an electric curt or potential to the reservoir cap effective to cause the reservoir cap to disintegrate. 8. The device of claim 1, further comprising an inner cap beneath the reservoir cap and in the opening, for passively controlling transport of molecules through the reservoir opening via diffusion of molecules through the inner cap. 9. The device of claim 8, wherein the inner cap comprises a polymeric material. 10. The device of claim 1, wherein the device is formed or coated with a biocompatible material, the device being suitable for implantation into a human or animal. 11. The device of claim 1, further comprising a glucose sensitive material in the interior of the reservoirs. 12. An implantable medical device for in vivo medical diagnostics comprising: a substrate; an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface; a diagnostic reagent in the interior of the reservoirs; a plurality of electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the array of reservoirs; and control circuitry for selectively disintegrating the reservoir cap over the opening of at least one of the reservoirs, wherein the device is formed or coated with a biocompatible material and is suitable for implantation into a human or animal. 13. The device of claim 12, wherein the electrodes are located on sidewalls of the reservoirs. 14. The device of claim 12, wherein the electrodes comprise a thin film of a conducting metal or doped semiconductor. 15. The device of claim 12, wherein the reservoir caps comprise a metal film. 16. The device of claim 12, wherein the substrate comprises silicon. 17. The device of claim 12, wherein the control circuitry is adapted to deliver an electric current or potential to the reservoir cap effective to cause the reservoir cap to disintegrate. 18. The device of claim 12, further comprising an inner cap beneath the reservoir cap and in the opening, for passively controlling transport of molecules through the reservoir open diffusion of molecules through the inner cap. 19. The device of claim 18, wherein the inner cap comprises a polymeric material. 20. A device for the controlled delivery of molecules comprising: a substrate; an array of reservoirs in the substrate; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate at least partially inside the reservoirs, wherein the one or more electrodes are not reservoir caps; and means for applying an electric current or potential across the one or more electrodes effective to activate release of the molecules from the reservoirs. 21. The device of claim 20, wherein the device is formed of or coated with a biocompatible material suitable for implantation into a human or animal. 22. The device of claim 20, wherein the release system comprises a matrix material and the molecules for release comprise drug molecules, which are dispersed in the matrix material. 23. The device of claim 22, wherein the matrix material comprises a biodegradable polymer. 24. The device of claim 22, wherein the matrix material disintegrates due to local pH changes induced by application of the electric potential or current. 25. The device of claim 22, wherein, upon application of the electric potential or current, the matrix material exchanges ions in solution with an ionically bound active substance in the release system. 26. The device of claim 20, further comprising reservoir caps positioned over the release system, wherein release of the molecules is controlled by diffusion through or disintegration of the reservoir caps. 27. The device of claim 26, wherein application of the electric current or potential across the one or more electrodes swells the release system to rupture the reservoir cap and release the molecules. 28. The device of claim 26, wherein the reservoir caps are outer reservoir caps, and the device further comprises inner reservoir caps positioned the reservoirs beneath the outer reservoir caps, wherein the inner reservoir caps are permeabilized or disintegrated to release the molecules after the outer reservoir caps are permeabilized or disintegrated. 29. The device of claim 26, wherein the reservoir caps are outer reservoir caps and the release system is a first release system layer, and the device further comprises at least one additional release system layer and at least one additional reservoir cap layer beneath the outer reservoir caps and first release system layer.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (59)
Heller Michael J. (Encinitas CA) Tu Eugene (San Diego CA), Active programmable electronic devices for molecular biological analysis and diagnostics.
Weinberg W. Henry ; McFarland Eric ; Goldwasser Isy ; Boussie Thomas ; Turner Howard ; Van Beek Johannes A. M. ; Murphy Vince ; Powers Timothy, Combinatorial synthesis and analysis of organometallic compounds and homogeneous catalysts.
Cherukuri Satyam Choudary ; Demers Robert Richard ; Fan Zhong Hui Hugh ; Levine Aaron W. ; McBride Sterling Edward ; Zanzucchi Peter John, Device for selective distribution of liquids.
Miller Larry L. (Minneapolis MN) Blankespoor Ronald L. (Grand Rapids MI) Zinger Baruch (Rehovot ILX), Electrochemical controlled release drug delivery system.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CA CAX) Gord John C. (Venice CA) Strojnik Primoz (Granada Hills CA), Implantable microstimulator.
Chien Yie W. (North Brunswick NJ) Kong-Jiann Li John (Plainsboro NJ) Liu Jue-Chen (East Brunswick NJ) Shi Wei-Min (Piscataway NJ) Siddiqui Ovais (Piscataway NJ) Sun Ying (King of Prussia PA), Iontotherapeutic device and process and iontotherapeutic unit dose.
Casper Robert A. (Raleigh NC) McCartney Michael L. (Durham NC) Jochem Warren J. (Cary NC) Parr Alan F. (Cary NC), Medical capsule device actuated by radio-frequency (RF) signal.
Erb Judith L. ; Downward James G. ; Erb-Downward John R. ; Ulrich Otho, Method and apparatus for measurement of binding between a protein and a nucleotide.
Shawgo, Rebecca S.; Sheppard, Jr., Norman F.; Cima, Michael J.; Santini, Jr., John T.; Herman, Stephen J.; Polito, Benjamin F.; Uhland, Scott A., Methods and devices for sealing microchip reservoir devices.
Uhland, Scott A.; Polito, Benjamin F.; Herman, Stephen J.; Santini, Jr., John T.; Maloney, John M., Methods for hermetically sealing microchip reservoir devices.
Whitesides George M. ; Xia Younan ; Wilbur James L. ; Jackman Rebecca J. ; Kim Enoch ; Prentiss Mara G. ; Mrksich Milan ; Kumar Amit ; Gorman Christopher B. ; Biebuyck Hans,CHX ; Berggren Karl K., Methods of etching articles via microcontact printing.
John T. Santini, Jr. ; Charles E. Hutchinson ; Scott A. Uhland ; Michael J. Cima ; Robert S. Langer ; Dennis Ausiello, Microfabricated devices for the delivery of molecules into a carrier fluid.
Santini, Jr., John T.; Hutchinson, Charles E.; Uhland, Scott A.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis, Microfabricated devices for the delivery of molecules into a carrier fluid.
Santini, Jr., John T.; Sheppard, Jr., Norman F.; Young, Chung Chang; Langer, Robert S., Microfabricated devices for the storage and selective exposure of chemicals and devices.
Kroy Walter (Ottobrunn DEX) Seidel Helmut (Starnberg DEX) Dette Eduard (Vagen DEX) Koniger Max (Munich DEX) Deimel Peter (Langenpreising DEX) Binder Florian (Traunstein DEX) Hilpert Reinhold (Munich , Micromechanical structure.
Maurer Donald D. (Anoka MN) Williams Thomas J. (Oak Grove MN) Stevens Scott A. (Minneapolis MN), Multiple site drug iontophoresis electronic device and method.
Jacobsen Stephen C. (Salt Lake City UT) Hanover Barry K. (Salt Lake City UT) Simon Eric M. (Salt Lake City UT) Petelenz Tomasz (Salt Lake City UT) Mladejovsky Michael G. (Murray UT), Multiple vesicle implantable drug delivery system.
Zanzucchi Peter J. (Lawrenceville NJ) Cherukuri Satyam C. (Cranbury NJ) McBride Sterling E. (Lawrenceville NJ), Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis.
Peery John R. ; Dionne Keith E. ; Eckenhoff James B. ; Landrau Felix A. ; Lautenbach Scott D. ; Magruder Judy A. ; Wright Jeremy C., Sustained delivery of an active agent using an implantable system.
Cozzette Stephen N. (Nepean CAX) Davis Graham (Plainsboro NJ) Itak Jeanne A. (North Brunswick NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisville PA) Piznik Sylvia (Jackson NJ) Smit Nicolaa, Wholly microfabricated biosensors and process for the manufacture and use thereof.
Uhland, Scott Albert; Peeters, Eric; Torres, Francisco E.; Schmaelzle, Philipp Helmut, Drug deactivation system and method of deactivating a drug using the same.
Ausiello, Dennis; Santini, Jr., John T.; Herman, Stephen J.; Prescott, James H.; Uhland, Scott A.; Maloney, John M.; Polito, Benjamin F., Implantable device for controlled, extended delivery of parathyroid hormone.
Sheppard, Jr., Norman F.; Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis, Method for wirelessly monitoring implanted medical device.
Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis; Sheppard, Jr., Norman F., Method of opening reservoir of containment device.
Uhland, Scott Albert; Peeters, Eric; Preas, Bryan Thomas; Martini, Joerg, Sensor system for drug delivery device, drug delivery device having the same and method of using the same.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., System, devices, and methods including catheters configured to monitor and inhibit biofilm formation.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including catheters having self-cleaning surfaces.
Boyden, Edward S.; Diaz, Roy P.; Hyde, Roderick A.; Kare, Jordin T.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Systems, devices, and methods including implantable devices with anti-microbial properties.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including infection-fighting and monitoring shunts.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including infection-fighting and monitoring shunts.
Dacey, Jr., Ralph G.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Kare, Jordin T.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Rivet, Dennis J.; Smith, Michael A.; Sweeney, Elizabeth A.; Tegreene, Clarence T.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Systems, devices, and methods including infection-fighting and monitoring shunts.
Kennedy, II, Kenneth C., Wire guides having novel outer surface areas and reservoirs for enhancing hydrophilic properties and delivering therapeutic agents.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.