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The present invention provides porous media or membranes having a surface coating that includes a first coating of a cross-linked terpolymer and a second coating comprising a copolymer or a terpolymer modified with a hydrophilic or hydrophobic functional group which has a superior combination of pro

The present invention provides porous media or membranes having a surface coating that includes a first coating of a cross-linked terpolymer and a second coating comprising a copolymer or a terpolymer modified with a hydrophilic or hydrophobic functional group which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter.

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What is claimed is: 1. A porous membrane comprising a polymeric microporous substrate membrane and a separately formed heat stable, biomolecule resistant surface having a biomolecule binding of less than about 30 micrograms per square centimeter as measured by the lgG binding test and a heat resist

What is claimed is: 1. A porous membrane comprising a polymeric microporous substrate membrane and a separately formed heat stable, biomolecule resistant surface having a biomolecule binding of less than about 30 micrograms per square centimeter as measured by the lgG binding test and a heat resistance of less than about twice the lgG adsorption of the same surface prior to heat exposure as measured by exposing the membrane to a method selected from the group consisting of heating to 135째 C. for two hours in an oven and heating to 121째 C. in a steam autoclave for one hour wherein said surface is comprised of a first polymeric coating and a second polymeric coating, the first coating being a crosslinked hydrophilic terpolymer and a second coating applied to the first coating, the second coating being a second polymer modified with functional groups and wherein the sizes of the pores of the porous membrane after applying the first and second coatings are not significantly different from the sizes of pores of the microporous substrate membrane before application of the first and second coatings. 2. The membrane of claim 1 having a biomolecule binding of less than about 20 micrograms per square centimeter as measured by the lgG binding test. 3. The membrane of any one of claims 1 or 2 wherein said microporous membrane being formed from one or more of the group consisting of an aromatic sulfone polymer, polytetrafluoroethylene, a perfluorinated thermoplastic polymer, a polyolefin polymer, ultrahigh molecular weight polyethylene, and polyvinylidene difluoride. 4. The membrane of any one of claims 1 or 2 wherein said substrate membrane is a microporous polyvinylidene difluoride membrane. 5. A clean, caustic resistant, porous membrane comprising a polymeric microporous substrate membrane and a heat stable biomolecule resistant surface, wherein said heat stable biomolecule resistant surface is a separately formed surface coating which comprises: a first coating comprising a first crosslinked terpolymer, said terpolymer comprising at least two monofunctional monomers selected from the group consisting of acrylamides, methacrylamides, and N-vinyl pyrrolidones, and at least one polyfunctional monomer selected from the group consisting of polyfunctional acrylamides, polyfunctional methacrylamides, and diacroylpiperazines and a second coating comprising a second crosslinked terpolymer, or copolymer modified with functional groups selected from the group consisting of hydrophilic functional groups and hydrophobic functional groups and wherein the sizes of the cores of the porous membrane after applying the first and second coatings are not significantly different from the sizes of pores of the microporous substrate membrane before application of the first and second coatings. 6. The membrane of claim 5 wherein said microporous substrate membrane is formed from one or more of the group consisting of an aromatic sulfone polymer, polytetrafluoroethylene, a perfluorinated thermoplastic polymer, a polyolefin polymer, ultrahigh molecular weight polyethylene, and polyvinylidene difluoride. 7. The membrane of claim 5 wherein said first crosslinked terpolymer of said first coating comprises at least one monofunctional monomer that is an acrylamide, wherein the acrylamide nitrogen of said acrylamide is substituted with at least one gem dialkyl substituted carbon. 8. The membrane of claim 6 wherein said first crosslinked terpolymer of said first coating comprises at least one monofunctional monomer that is an acrylamide, wherein the acrylamide nitrogen of said acrylamide is substituted with at least one gem dialkyl substituted carbon. 9. The membrane of claim 5 wherein said first crosslinked terpolymer of said first coating is a copolymer formed from dimethylacrylamide, diacetone acrylamide, and methylene-bis-acrylamide. 10. The membrane of claim 5 wherein said first crosslinked terpolymer of said first coating is a copolymer formed from dimethylacrylamide, diacetone acrylamide, and methylene-bis-acrylamide. 11. The membrane of claim 5 wherein said first crosslinked terpolymer of said first coating is a copolymer formed from methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide. 12. The membrane of claim 6 wherein said first crosslinked terpolymer of said first coating is a copolymer formed from methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide. 13. The membrane of claim 5 wherein said second crosslinked terpolymer or copolymer is modified with fluoroalkyl groups. 14. A clean, caustic resistant, porous membrane comprising a polyvinylidene difluoride microporous substrate membrane and a heat stable biomolecule resistant surface formed of two polymer coatings, wherein said first coating is a separately formed surface coating which comprises a first crosslinked terpolymer, said crosslinked terpolymer of said first coating being a copolymer formed from either: (a) methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide; or (b) methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide, and a second coating comprising a second crosslinked terpolymer or copolymer modified with functional groups selected from the group consisting of hydrophilic functional groups and hydrophobic groups, and wherein the sizes of the pores of the porous membrane after applying the first and second coatings are not significantly different from the sizes of cores of the microporous substrate membrane before application of the first and second coatings. 15. The membrane of claim 14 wherein said crosslinked terpolymer of said first coating is a copolymer formed from methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide. 16. The membrane of claim 14 wherein said crosslinked terpolymer of said first coating is a copolymer formed from methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide. 17. The membrane of claim 14 wherein said first coating is a separately formed surface coating; said surface coating comprising a crosslinked terpolymer; said crosslinked terpolymer comprising: at least one polyfunctional monomer selected from the group consisting of polyfunctional acrylamide monomers, polyfunctional methacrylamide monomers, and diacroylpiperazines; and at least two different monofunctional monomers selected from the group of N-vinyl pyrrolidone monomers and monomers having the formula: H2 C=C(R1)C(=O)N(R2) (R3) wherein: R1 is--H or CH3, R2 is H or C1-C6, preferably C 1-C3 alkyl, either linear or branched, R3 is H or C1-C6, preferably C 1-C3 alkyl, either linear or branched, or C(CH3) 2CH2C(═O)CH3, or (P═O)((NCH3 )2)2, or C═ON(CH3)2, or CH 2--O--R4, where R4 is C1-C5 alkyl, either linear or branched, or (CH2--CH2--O)n-R5, where R5 is--H or OH3, and n=2 or 3; provided that R2 and R3are not simultaneously H. 18. The membrane of claim 14 wherein said second crosslinked terpolymer or copolymer is modified with fluoroalkyl groups. 19. The membrane of any one of claims 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16 or 17 wherein said hydrophilic functional group is a quaternary ammonium salt. 20. A clean, caustic resistant, porous membrane comprising a microporous membrane substrate and a heat stable biomolecule resistant surface, wherein said heat stable biomolecule resistant surface is formed of two separately formed polymeric coatings which comprise: a first coating comprising a first crosslinked terpolymer, said terpolymer comprising at least two monofunctional monomers selected from the group consisting of acrylamides, methacrylamides, and N-vinyl pyrrolidones, and at least one polyfunctional monomer selected from the group consisting of polyfunctional acrylamides, polyfunctional methacrylamides, and diacroylpiperazines and a second coating comprising a second crosslinked terpolymer, or copolymer modified with functional groups selected from the group consisting of hydrophilic functional groups and hydrophobic functional groups, wherein said second coating is a polymer formed from a monomer selected from the group consisting of (3-(methacryloylamino) propyl)trimethylammonium chloride, (3-acrylamidopropyl)trimethylammonium chloride, 2-acrylamido-2-methyl-1-propanesulfonic acid and aminopropylmethacrylamide.