IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0669094
(2003-09-22)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
Wilson Sonsini Goodrich &
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인용정보 |
피인용 횟수 :
32 인용 특허 :
4 |
초록
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The present invention provides novel compositions and methods for protecting and promoting cell growth and restoring physiological structure and function to mucosal tissue of the body, especially mucosa in the gastrointestinal tract. The composition can be used as a pharmaceutical or nutraceutical t
The present invention provides novel compositions and methods for protecting and promoting cell growth and restoring physiological structure and function to mucosal tissue of the body, especially mucosa in the gastrointestinal tract. The composition can be used as a pharmaceutical or nutraceutical to treat a gastrointestinal disorder or to promote general health of an animal, preferably a human. The composition is in an oral dosage form and comprises edible oil homogenized with a sterol compound at a concentration of at least 0.5% by weight and edible wax at a concentration ranging from 3% to 30% by weight. The composition can also be used to deliver other active ingredients to the gastrointestinal tract for treating various diseases.
대표청구항
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What is claimed is: 1. A composition suitable for oral administration comprising: an edible oil that is homogenized with i) an edible wax at a concentration ranging from 0.5% to 50% by weight based on the total weight of the composition, and ii) a sterol compound selected from the group consisting
What is claimed is: 1. A composition suitable for oral administration comprising: an edible oil that is homogenized with i) an edible wax at a concentration ranging from 0.5% to 50% by weight based on the total weight of the composition, and ii) a sterol compound selected from the group consisting of stigmasterol, campesterol, β-sitosterol, chalinosterol, clionasterol, brassicasterol, α-spinasterol, daucosterol, desmosterol, and poriferasterol, at a concentration of at least 0.1% by weight based on the total weight of the composition wherein the edible oil, edible wax and sterol compound are homogenized to form colloid with the edible wax adopting a microcrystal form at ambient temperature. 2. The composition of claim 1, wherein the concentration of the sterol compound is 0.5% to 20% by weight. 3. The composition of claim 1, wherein the concentration of the sterol compound is 1% to 10% by weight. 4. The composition of claim 1, wherein the concentration of the edible wax is 3% to 30% by weight. 5. The composition of claim 1, wherein the concentration of the edible wax is 5% to 20% by weight. 6. The composition of claim 1, wherein the concentration of the edible wax is 6% to 10% by weight. 7. The composition of claim 1, wherein the edible wax is selected from the group consisting of beeswax, castorwax, glycowax, and carnaubawax. 8. The composition of claim 1, wherein the edible oil is an animal or plant oil. 9. The composition of claim 1, wherein the edible oil is selected from the group consisting of corn oil, wheat germ oil, soy bean oil, rice bran oil, rapeseed oil, sesame oil, and fish oil. 10. The composition of claim 1, wherein the edible oil is sesame oil. 11. The composition of claim 1, further comprising propolis at a concentration ranging from 0.1 % to 30% by weight based on the total weight of the composition. 12. The composition of claim 1, wherein the composition contains less than 1% of water by weight. 13. The composition of claim 1, wherein the composition contains less than 0.1% of water by weight. 14. The composition of claim 1, wherein the composition is formulated in an oral dosage form selected from the group consisting of tablets, pills, dragees, capsules, emulsions, gels, syrups, slurries, and suspensions. 15. The composition of claim 1, wherein the composition is formulated in a soft or hard gel capsule. 16. The composition of claim 1, wherein the sterol compound is a combination of stigmasterol, β-sitosterol, and campesterol. 17. The composition of claim 1, wherein the sterol compound is β-sitosterol. 18. The composition of claim 1, further comprising baicalin. 19. The composition of claim 18, wherein baicalin is at a concentration ranging from about 0.01 to 5% by weight based on the total weight of the composition. 20. The composition of claim 1, further comprising an extract of huangqin (Scutellaria baicalensis Georgi) in aqueous solution, organic solvent or a combination thereof. 21. The composition of claim 23, wherein huangqin is selected from the group consisting of Scutellaria viscidula Bge, Scutellaria amoena C. H. Wright, Scutellaria rehderiana Diels, Scutellaria ikonnikovii Juz, Scutellaria likiangensis Diels and Scutellaria hypericifolia Levl of Labiatae Family. 22. The composition of claim 1, further comprising obaculactone. 23. The composition of claim 22, wherein the concentration of obaculactone is 0.01-50% by weight based on the total weight of the composition. 24. The composition of claim 1, further comprising an extract of huangbai (Phellodendron amurense Rupr) in aqueous solution, organic solvent or a combination thereof. 25. The composition of claim 24, wherein huangbai is selected from the group consisting of Phellodendron chinense Schneid, Plellodendron chinense Scheid var. glabriusculum Schneid, Phellodendron chinense Schneid var. omeiense Huang, Phellodendron Schneid var. yunnanense Huang and Phellodendron chinense Schneid var. falcutum Huang. 26. The composition of claim 1, further comprising obabenine. 27. The composition of claim 31, wherein the concentration of obabenine ranges from 0.001% to 5% by weight based on the total weight of the composition. 28. The composition of claim 1, further comprising an extract of huanglian (coptis chinensis Franch) in aqueous solution, organic solvent or a combination thereof. 29. The composition of claim 28, wherein huanglian is selected from the group consisting of Coptis deltoidea C. Y. Cheng et Hsiao, Coptis omeiensis (Chen) C. Y. Cheng, and Coptis teetoides C. Y. Cheng of Ranunculaceae Family. 30. The composition of claim 1, further comprising berberine at a concentration ranging from about 0.001% to 5% by weight based on the total weight of the composition. 31. The composition of claim 1, further comprising narcotoline at a concentration ranging from about 0.001% to 2% by weight based on the total weight of the composition. 32. The composition of claim 1, further comprising an extract of poppy capsule (Papaver somniferam L.) in aqueous solution, organic solvent or a combination thereof. 33. The composition of claim 1, further comprising an extract of a combination of huangqin, huangbai and huanglian in aqueous solution, organic solvent or a combination thereof. 34. The composition of claim 1, further comprising an extract of a combination of huangqin, huangbai, huanglian and poppy capsule in aqueous solution, organic solvent or a combination thereof. 35. The composition of claim 1, further comprising an extract of earthworms in aqueous solution, organic solvent or a combination thereof. 36. The composition of claim 1, further comprising an extract of a combination of huangqin, huangbai, huanglian, poppy capsule and earthworms in aqueous solution, organic solvent or a combination thereof. 37. The composition of claim 1, wherein the edible wax is beeswax. 38. The composition of claim 37, wherein the microcrystal form of beeswax is 0.1-100 μm in length. 39. The composition of claim 37, wherein at least two of the microcrystals of beeswax aggregate to form a microcrystal complex. 40. The composition of claim 37, wherein the microcrystals of beeswax are dispersed substantially uniformly in the edible oil. 41. The composition of claim 1, further comprising: a pharmaceutically active ingredient. 42. The composition of claim 41, wherein edible wax is beeswax. 43. The composition of claim 42, wherein the pharmaceutically active ingredient is selected from the group consisting of gastrointestinal agents, antibiotics, antiviral agents, antifungal agents, antineoplastic agents, analgesics, tranquilizers, narcotic antagonists, antidepressants, antihistamines, antimigraine, cardiovascular drugs, calcium channel blockers, appetite suppressant, contraceptive agents, corticosteroids, local anaesthetics, diuretics, antihypertensive agents, steroids, prostaglandins, anti-inflammatory drugs, antithrombotic agents, cardiac glycosides, antiparkinsonism, chemical dependency drugs, acidic drugs, and peptides. 44. The composition of claim 42, wherein the pharmaceutically active ingredient is a salicylate. 45. The composition of claim 44, wherein the salicylate is aspirin.
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