초록 ▼

Apparatus and methods for regulating the appetite of an individual suffering from morbid obesity, the apparatus including a plurality of stimulation electrodes arranged longitudinally on at least one electrode support shaft for insertion within the hypothalamus for outputting electrical discharges t

Apparatus and methods for regulating the appetite of an individual suffering from morbid obesity, the apparatus including a plurality of stimulation electrodes arranged longitudinally on at least one electrode support shaft for insertion within the hypothalamus for outputting electrical discharges to specific sites within the hypothalamus. Each of the plurality of stimulation electrodes may be independently controlled. Electrical discharge of various frequencies transmitted from one or more of the plurality of stimulation electrodes, and delivered to a region of the hypothalamus that is involved with either stimulating or inhibiting appetite, may be used to regulate appetite in the individual. Alternatively, an individual's appetite may be regulated by the microinfusion from at least one microinfusion catheter of an appropriate quantity of a suitable drug to a distinct site or region within the hypothalamus.

대표청구항 ▼

What is claimed is: 1. A drug infusion device, comprising: a macrocatheter; and a plurality of microinfusion catheters disposed non-coaxially side-by-side within the macrocatheter, wherein at least one microinfusion catheter comprises a plurality of drug delivery ports and is configured to receive

What is claimed is: 1. A drug infusion device, comprising: a macrocatheter; and a plurality of microinfusion catheters disposed non-coaxially side-by-side within the macrocatheter, wherein at least one microinfusion catheter comprises a plurality of drug delivery ports and is configured to receive a drug and infuse the drug into a tissue of a patient, and wherein the plurality of drug delivery ports comprises individually controllable drug delivery ports. 2. A drug infusion device, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to receive a drug and infuse the drug into a tissue of a patient, wherein at least one microinfusion catheter comprises a plurality of individually controllable drug delivery ports disposed along a length of the at least one microinfusion catheter; and a macrocatheter configured to house the plurality of microinfusion catheters. 3. The drug infusion device of claim 2, wherein the tissue comprises the hypothalamus. 4. The drug infusion assembly of claim 2, wherein the macrocatheter comprises a magnet configured to cooperate with an external magnetic field to guide the macrocatheter. 5. A drug infusion assembly comprising the drug infusion device of claim 2, and further comprising a pump configured to deliver the drug to at least one microinfusion catheter of the plurality of microinfusion catheters. 6. The drug infusion assembly of claim 5, wherein the pump is configured to be controlled percutaneously. 7. The drug infusion assembly of claim 5, further comprising a manifold configured to convey the drug from the pump to the at least one microinfusion catheter. 8. A drug infusion device, comprising: a macrocatheter; and a plurality of microinfusion catheters disposed non-coaxially side-by-side within the macrocatheter, wherein at least one microinfusion catheter of the plurality of microinfusion catheters is movable and comprises a plurality of individually controllable drug delivery ports, wherein the at least one microinfusion catheter is configured to receive a drug and infuse the drug into a tissue of a patient, and wherein the macrocatheter comprises a magnet configured to aid in the stereotactic placement of the macrocatheter in the tissue. 9. The drug infusion assembly of claim 1, wherein the magnet comprises a magnetic collar disposed on the macrocatheter proximate to an end of the macro catheter. 10. A drug infusion device, comprising: a macrocatheter; a plurality of microinfusion catheters disposed non-coaxially side-by-side within the macrocatheter, wherein at least one of said plurality of microinfusion catheters comprises a plurality of drug delivery ports and is configured to receive a drug and infuse the drug into a tissue of a patient; and at least one pump configured to controllably supply the drug to the at least one microinfusion catheter, wherein the at least one pump is configured to be controlled percutaneously. 11. The drug infusion assembly of claim 10, further comprising a manifold configured to convey the drug from the at least one pump to the at least one microinfusion catheter. 12. A drug infusion device, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to receive a drug and infuse the drug into the hypothalamus of a patient; a pump configured to controllably supply a drug to the plurality of microinfusion catheters; and a manifold configured to convey the drug from the pump to the plurality of microinfusion catheters, wherein at least one microinfusion catheter comprises multiple individually controllable drug delivery ports disposed along a length of the at least one microinfusion catheter. 13. A drug infusion device, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to receive a drug and infuse the drug into a hypothalamus of a patient; at least one electrode configured to sense electrical activity of the hypothalamus; a pump configured to controllably supply a drug to the plurality of microinfusion catheters, wherein the pump is configured to communicate with the at least one electrode and supply the drug to at least one of the plurality of microinfusion catheters in accordance with the electrical activity of the hypothalamus; and a manifold configured to convey the drug from the pump to the plurality of microinfusion catheters. 14. A drug infusion assembly for microinfusing a drug into the hypothalamus of a patient's brain, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to be inserted into the hypothalamus of a patient's brain, wherein at least one microinfusion catheter of said plurality of microinfusion catheters comprises a plurality of drug delivery ports arranged such that each drug delivery port of the plurality of drug delivery ports is configured to deliver a drug to a separate site within the hypothalamus; a macrocatheter for housing the plurality of microinfusion catheters; a drug delivery manifold, wherein each of said plurality of microinfusion catheters is functionally coupled to said drug delivery manifold; a drug supply line functionally coupled to said drug delivery manifold; and a drug reservoir and pump for retaining and for pumping a drug, said drug reservoir and pump being functionally coupled to said drug supply line, wherein said drug reservoir and pump are capable of pumping a drug at a variable rate, and the variable rate can be controlled percutaneously. 15. The drug infusion assembly as claimed in claim 14, wherein said macrocatheter includes a magnetic unit, said magnetic unit being configured such that application of an external magnetic field allows for stereotactic placement of said macrocatheter to a specific location within the patient's brain. 16. The drug infusion assembly as claimed in claim 14, wherein said macrocatheter includes a magnet located at a distal end of said macrocatheter. 17. The drug infusion assembly as claimed in claim 14, wherein said drug reservoir and pump are capable of pumping a drug at a variable rate. 18. The drug infusion assembly as claimed in claim 14, wherein said drug reservoir and pump include a recharge valve for recharging said drug reservoir and pump with a drug. 19. The drug infusion assembly as claimed in claim 18, wherein said recharge valve is accessible percutaneously. 20. The drug infusion assembly as claimed in claim 14, wherein the drug reservoir and pump contains and supplies an appetite controlling drug for treating obesity. 21. The drug infusion assembly as claimed in claim 14, wherein at least one microinfusion catheter of the plurality of microinfusion catheters is configured such that each of the plurality of drug delivery ports can be independently controlled. 22. The drug infusion assembly as claimed in claim 14, further comprising monitoring electrodes which sense electrical activity within the patient's hypothalamus. 23. The drug infusion assembly as claimed in claim 22, wherein the at least one microinfusion catheter of the plurality of microinfusion catheters is configured to independently deliver a drug from each of the plurality of drug delivery ports of the at least one microinfusion catheter based on information gathered from the monitoring electrodes. 24. The drug infusion assembly of claim 14, wherein the plurality of drug delivery ports is disposed along a length of the at least one microinfusion catheter. 25. The drug infusion assembly as claimed in claim 14, wherein said drug reservoir and said pump comprise a combined drug reservoir and pump. 26. A drug infusion device, comprising: a macrocatheter; a plurality of microinfusion catheters extending through the macrocatheter and movably disposed non-coaxially side-by-side with respect to one another, wherein each of the plurality of microfusion catheters is configured to receive a drug, and wherein an end portion of each of the plurality of microinfusion catheters is configured to extend beyond an end of the macrocatheter so as to infuse the drug into the hypothalamus of a patient; a pump configured to controllably supply a drug to the plurality of microinfusion catheters; a manifold configured to convey the drug from the pump to the plurality of microinfusion catheter; and at least one electrode configured to sense electrical activity of the hypothalamus, wherein the pump is configured to communicate with the at least one electrode and supply the drug to at least one of the plurality of microinfusion catheters in accordance with the electrical activity of the hypothalamus. 27. The drug infusion assembly of claim 26, wherein the pump can be controlled percutaneously. 28. The drug infusion assembly of claim 26, wherein at least one microinfusion catheter comprises multiple individually controllable drug delivery ports disposed along a length of the at least one microinfusion catheter. 29. The drug infusion assembly of claim 26, wherein the macrocatheter comprises a magnet. 30. The drug infusion assembly of claim 26, wherein the drug is configured to affect the weight of the patient. 31. A drug infusion device, comprising: a macrocatheter, comprising a magnet configured to aid in the stereotactic placement of the macrocatheter, wherein the magnet comprises a magnetic collar disposed on the macrocatheter proximate to an end of the macrocatheter; and a plurality of microinfusion catheters disposed non-coaxially side-by-side within the macrocatheter, wherein at least one of said plurality of microinfusion catheters comprises a plurality of drug delivery ports and is configured to receive a drug and infuse the drug into a tissue of a patient, and wherein at least one of said plurality of microinfusion catheters is movable within said macrocatheter. 32. The drug infusion device of claim 31, wherein the plurality of drug delivery ports comprises individually controllable drug delivery ports. 33. The drug infusion device of claim 31, wherein the plurality of drug delivery ports are disposed along a length of the at least one microinfusion catheter. 34. A drug infusion assembly comprising the drug infusion device of claim 31, and further comprising at least one pump configured to controllably supply the drug to the at least one microinfusion catheter. 35. The drug infusion assembly of claim 34, wherein the at least one pump is configured to be controlled percutaneously. 36. The drug infusion assembly of claim 34, further comprising a manifold configured to convey the drug from the at least one pump to the at least one microinfusion catheter. 37. A drug infusion assembly for microinfusing a drug into the hypothalamus of a patient's brain, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to be inserted into the hypothalamus of a patient's brain, wherein at least one microinfusion catheter of said plurality of microinfusion catheters comprises a plurality of drug delivery ports arranged to deliver a drug to a separate site within the hypothalamus; a drug delivery manifold, wherein each of said plurality of microinfusion catheters is functionally coupled to said drug delivery manifold; a drug supply line functionally coupled to said drug delivery manifold; and a drug reservoir and pump for retaining and pumping a drug, said drug reservoir and pump being functionally coupled to said drug supply line, wherein said drug reservoir and pump includes a recharge valve for recharging said drug reservoir and pump with a drug. 38. The drug infusion assembly as claimed in claim 37, wherein said recharge valve is accessible percutaneously. 39. The drug infusion assembly as claimed in claim 37, wherein said drug reservoir and said pump comprise a combined drug reservoir and pump. 40. A drug infusion assembly for microinfusing a drug into the hypothalamus of a patient's brain, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to be inserted into the hypothalamus of a patient's brain, wherein at least one microinfusion catheter of said plurality of microinfusion catheters comprises a plurality of drug delivery ports arranged to deliver a drug to a separate site within the hypothalamus; a drug delivery manifold, wherein each of said plurality of microinfusion catheters is functionally coupled to said drug delivery manifold; a drug supply line functionally coupled to said drug delivery manifold; and a drug reservoir and pump for retaining and pumping a drug, said drug reservoir and pump being functionally coupled to said drug supply line, wherein at least one microinfusion catheter of the plurality of microinfusion catheters is configured such that each of the plurality of drug delivery ports can be independently controlled. 41. The drug infusion assembly as claimed in claim 40, wherein said drug reservoir and said pump comprise a combined drug reservoir and pump. 42. A drug infusion assembly for microinfusing a drug into the hypothalamus of a patient's brain, comprising: a plurality of microinfusion catheters disposed non-coaxially side-by-side with respect to one another and configured to be inserted into the hypothalamus of a patient's brain, wherein at least one microinfusion catheter of said plurality of microinfusion catheters comprises a plurality of drug delivery ports arranged to deliver a drug to a separate site within the hypothalamus; a drug delivery manifold, wherein each of said plurality of microinfusion catheters is functionally coupled to said drug delivery manifold; monitoring electrodes that sense electrical activity within the patient's hypothalamus; a drug supply line functionally coupled to said drug delivery manifold; and a drug reservoir and pump for retaining and pumping a drug, said drug reservoir and pump being functionally coupled to said drug supply line, wherein the at least one microinfusion catheter is configured to independently deliver a drug from each of the plurality of drug delivery ports based on information gathered from the monitoring electrodes. 43. The drug infusion assembly as claimed in claim 42, wherein said drug reservoir and said pump comprise a combined drug reservoir and pump.