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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0877527 (2004-06-24) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 44 인용 특허 : 785 |
An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the impl
An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.
What is claimed is: 1. A method of reducing or eliminating a formation of a thrombus in a patient's vasculature, wherein the method comprises implanting a medical device in a patient's vasculature and allowing the medical device produced by the method comprising: depositing a coating devoid of hepa
What is claimed is: 1. A method of reducing or eliminating a formation of a thrombus in a patient's vasculature, wherein the method comprises implanting a medical device in a patient's vasculature and allowing the medical device produced by the method comprising: depositing a coating devoid of heparin on the medical device that is implantable within a lumen of a vascular system; wherein, the lumen is defined by vessel walls; the medical device comprises surfaces capable of contacting the vessel walls and surfaces incapable of contacting the vessel walls upon implantation; the coating devoid of heparin comprises a material that deposits on the medical device and includes functional groups that attract heparin, bond with heparin, or a combination thereof, when the material is exposed to a solution comprising heparin; wherein, the depositing occurs exclusively on surfaces of the medical device that are incapable of contacting the vessel walls thus providing for delivery of heparin to a specific site in a patient and avoiding a toxic effect within the patient's vasculature; and exposing the medical device to heparinized blood such that heparin attaches to the coating exclusively on surfaces of the medical device that are incapable of contacting the vessel walls; to remain in the vasculature for a period of time during which the heparin attached to the coating can reduce or eliminate thrombus formation, after which period, the medical device is exposed to an additional dosage of heparin. 2. A method of reducing or eliminating a formation of a thrombus in a patient's vasculature wherein the method comprises implanting a medical device in a patient's vasculature and allowing the medical device produced by the method comprising: depositing a coating devoid of heparin on the medical device that is implantable within a lumen of a patient; wherein, the lumen is defined by vessel walls; the medical device comprises surfaces capable of contacting the vessel walls and surfaces incapable of contacting the vessel walls upon implantation; the coating devoid of heparin comprises a material that deposits on the medical device and includes functional groups that attract heparin, bond with heparin, or a combination thereof, when the material is exposed to a solution comprising heparin; wherein, the depositing occurs exclusively on surfaces of the medical device that are incapable of contacting the vessel walls thus providing for delivery of heparin to a specific site in a patient and avoiding a toxic effect within the patient; sterilizing and storing the medical device having the coating deposited thereon; and exposing the coated body medical device to the solution comprising heparin, such that the heparin attaches to the coating exclusively on surfaces of the medical device that are incapable of contacting the vessel walls; to remain in the vasculature for a period of time in which the heparin attached to the coating can reduce or eliminate thrombus formation, after which period, the medical device is exposed to an additional dosage of heparin. 3. The method of claim 1, wherein the bonding of the coating with heparin comprises ionic bonding. 4. The method of claim 1, wherein the medical device further comprises a support structure, and exposing the implantable support structure to heparinized blood comprises delivering heparin from a catheter to the patient. 5. The method of claim 4, wherein the support structure is a stent. 6. The method of claim 4, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls and surfaces that face the blood flow, wherein the surfaces of the medical device that are incapable of contacting the vessel walls comprise the surfaces that face the blood flow, and wherein the coating is exclusively deposited on the surfaces that face the blood flow. 7. The method of claim 4, wherein the support structure is configured such that upon implantation in a blood vessel, such support structure has surfaces that face the vessel walls, surfaces that face the blood flow, and end surfaces comprising an upstream edge surface and a downstream edge surface, wherein the surfaces of the medical device that are incapable of contacting the vessel walls comprise the upstream edge surface and the downstream edge surface, and wherein the coating is exclusively deposited on at least one of the end surfaces. 8. The method of claim 1, wherein the coating comprises a layer that is deposited on the medical device by dipping, spraying, molding, plasma deposition, or a combination thereof. 9. The method of claim 1, wherein the coating comprises a layer that is deposited on the medical device by plasma deposition. 10. The method of claim 1, wherein the coating is deposited by first depositing a base layer, selected for its ability to adhere to the medical device and then depositing thereon a top layer selected for its ability to bond to the base layer and avail the functional groups for attachment to the heparin. 11. The method of claim 1, wherein the functional groups comprise functional groups that are selected from a group consisting of amine groups, carboxyl groups, and a combination thereof. 12. The method of claim 2, wherein the medical device comprises a support structure. 13. The method of claim 12, wherein the support structure comprises a stent. 14. The method of claim 12, wherein the support structure is configured such that upon implantation in a patient, such support structure has surfaces that face the vessel walls and surfaces that face blood flow, wherein the surfaces of the medical device that are incapable of contacting the vessel walls comprise the surfaces that face the blood flow, and wherein the coating is exclusively deposited on the surfaces that face the blood flow. 15. The method of claim 12, wherein the support structure is configured such that upon implantation in a patient, such support structure has surfaces that face the vessel walls, surfaces that face blood flow, and end surfaces comprising an upstream edge surface and a downstream edge surface, wherein the surfaces of the medical device that are incapable of contacting the vessel walls comprise the upstream edge surface and the downstream edge surface, and wherein the coating is exclusively deposited on at least one of the end surfaces. 16. The method of claim 2, wherein the coating is deposited on the medical device by dipping, spraying, molding, plasma deposition, or a combination thereof. 17. The method of claim 2, wherein the coating comprises a layer that is deposited on the medical device by plasma deposition. 18. The method of claim 2, wherein the coating is deposited by first depositing a base layer, selected for its ability to adhere to the medical device and then depositing thereon a top layer selected for its ability to bond to the base layer and avail the functional groups for attachment to the heparin. 19. The method of claim 2, wherein the functional groups comprise functional groups that are selected from a group consisting of amine groups, carboxyl groups, and a combination thereof. 20. The method of claim 2, wherein the bonding of the coating with heparin comprises ionic bonding.
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