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A cryotherapy system is provided with multiple cryoprobes, each of which has a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end. A source is provided for the cryogenic fluid, and fl

A cryotherapy system is provided with multiple cryoprobes, each of which has a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end. A source is provided for the cryogenic fluid, and flow-control metering valves are provided in fluid communication with the conduits and source of the cryogenic fluid. A compressor is provided in fluid communication with the conduits of the cryoprobes to define a self-contained fluid system. The flow-control metering valves and the compressor are controlled by a computer processor to provide the desired flows of the cryogenic fluid through the conduits of the self-contained fluid system.

대표청구항 ▼

What is claimed is: 1. A cryotherapy system comprising: a plurality of cryoprobes, each such cryoprobe having a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end; a source of the cr

What is claimed is: 1. A cryotherapy system comprising: a plurality of cryoprobes, each such cryoprobe having a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end; a source of the cryogenic fluid; a plurality of flow-control metering valves in fluid communication with the conduits of the plurality of cryoprobes and with the source of the cryogenic fluid; a compressor in fluid communication with the conduits of the plurality of cryoprobes to define a self-contained fluid system; and a computer processor comprising: instructions to control the plurality of flow-control metering valves and the compressor to provide desired flows of the cryogenic fluid through the conduits of the self-contained fluid system; and instructions to control the compressor and the plurality of flow-control metering valves to provide an initial flow of the cryogenic fluid through the conduits of the cryoprobes under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid, wherein the critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with freezing of the cryoprobes is avoided. 2. The cryotherapy system recited in claim 1 wherein the self-contained fluid system is an open-loop system. 3. The cryotherapy system recited in claim 1 wherein the self-contained fluid system is a closed-loop system. 4. The cryotherapy system recited in claim 1 wherein: the cryogenic fluid is a gas; and each such cryoprobe further has a heat exchanger disposed within the shaft in thermal communication with the conduits of such cryoprobe. 5. The cryotherapy system recited in claim 4 wherein: each of the plurality of cryoprobes includes a Joule-Thomson port disposed in the distal end of the shaft in thermal communication with the heat exchanger; and the computer processor further comprises instructions to control operation of each of the Joule-Thomson ports. 6. The cryotherapy system recited in claim 1 wherein the computer processor further comprises instructions subsequently to reduce a pressure of the fluid in the cryoprobes, whereby colder fluid temperatures may be maintained without vapor lock after the initial flow is established. 7. The cryotherapy system recited in claim 1 wherein the compressor comprises a submersible pump for compressing ambient cryogenic fluids. 8. The cryotherapy system recited in claim 7 wherein: the compressor comprises a heat exchanger to remove heat of compression through heat exchange of the compressed cryogenic fluid with the ambient cryogenic fluids. 9. The cryotherapy system recited in claim 7 wherein: the plurality of cryoprobes are in fluid communication with the submersible pump through respective supply lines; and the computer processor is further comprises instructions to set a freeze power of the plurality of cryoprobes by regulating flow through the respective supply lines. 10. The cryotherapy system recited in claim 1 wherein the compressor comprises a push-pull bellow system and a linear actuator motor. 11. The cryotherapy system recited in claim 10 wherein the computer processor further comprises instructions to control a force exerted by the linear actuator motor to set a pressure of the cryogenic fluid. 12. The cryotherapy system recited in claim 1 further comprising a source of warmed gas in fluid communication with the flow-control metering valves, wherein the computer processor further comprises instructions to control the flow-control metering valves to initiate flow of the warmed gas through the conduits as part of an active thaw procedure. 13. The cryotherapy system recited in claim 1 wherein the computer processor further comprises instructions to determine the desired flows from predefined imaging parameters. 14. The cryotherapy system recited in claim 13 wherein the predefined imaging parameters correspond to a definition of freeze margins in the body. 15. The cryotherapy system recited in claim 1 wherein: each of the plurality of cryoprobes further has a plurality of multifunction electrical wires; and the computer processor comprises instructions to monitor the operation of the multifunction electrical wires. 16. The cryotherapy system recited in claim 15 wherein the computer processor comprises instructions to monitor operation of the multifunction electrical wires to monitor a temperature. 17. The cryotherapy system recited in claim 15 wherein the computer processor comprises instructions to monitor operation of the multifunction electrical wires to provide heat. 18. The cryotherapy system recited in claim 15 wherein: the body is a living body; and the computer processor comprises instructions to monitor the operation of the multifunction electrical wires to stimulate a nerve within the living body. 19. The cryotherapy system recited in claim 15 wherein the computer processor comprises instructions to monitor the operation of the multifunction electrical wires to permit spatial localization of the cryoprobes. 20. The cryotherapy system recited in claim 1 wherein: the ends of the cryoprobes comprise an electrically insulating material; and the computer processor further comprises instructions to force current between the ends of the cryoprobes to heat intervening portions of the body. 21. The cryotherapy system recited in claim 1 wherein the computer processor further comprises instructions to initiate injection of a cryosensitizing substance into the body.